ANS binding reveals common features of cytotoxic amyloid species
Oligomeric assemblies formed from a variety of disease-associated peptides and proteins have been strongly associated with toxicity in many neurodegenerative conditions, such as Alzheimer's disease. The precise nature of the toxic agents, however, remains still to be established. We show that p...
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ftunivwollongong:oai:ro.uow.edu.au:scipapers-2017 2023-05-15T15:03:04+02:00 ANS binding reveals common features of cytotoxic amyloid species Bolognesi, Benedetta Kumita, Janet R Barros, Teresa P Esbjorner, Elin K Luheshi, Leila M Crowther, Damian C Wilson, Mark R Dobson, Christopher M Favrin, Giorgio Yerbury, Justin J 2010-01-01T08:00:00Z https://ro.uow.edu.au/scipapers/974 unknown Research Online https://ro.uow.edu.au/scipapers/974 Faculty of Science - Papers (Archive) binding reveals common features cytotoxic amyloid ans species CMMB Life Sciences Physical Sciences and Mathematics Social and Behavioral Sciences article 2010 ftunivwollongong 2020-02-25T11:43:23Z Oligomeric assemblies formed from a variety of disease-associated peptides and proteins have been strongly associated with toxicity in many neurodegenerative conditions, such as Alzheimer's disease. The precise nature of the toxic agents, however, remains still to be established. We show that prefibrillar aggregates of E22G (arctic) variant of the A beta(1-42) peptide bind strongly to 1-anilinonaphthalene 8-sulfonate and that changes in this property correlate significantly with changes in its cytotoxicity. Moreover, we show that this phenomenon is common to other amyloid systems, such as wild-type A beta(1-42), the 159T variant of human lysozyme and an SH3 domain. These findings are consistent with a model in which the exposure of hydrophobic surfaces as a result of the aggregation of misfolded species is a crucial and common feature of these pathogenic species. Article in Journal/Newspaper Arctic University of Wollongong, Australia: Research Online Arctic |
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Open Polar |
collection |
University of Wollongong, Australia: Research Online |
op_collection_id |
ftunivwollongong |
language |
unknown |
topic |
binding reveals common features cytotoxic amyloid ans species CMMB Life Sciences Physical Sciences and Mathematics Social and Behavioral Sciences |
spellingShingle |
binding reveals common features cytotoxic amyloid ans species CMMB Life Sciences Physical Sciences and Mathematics Social and Behavioral Sciences Bolognesi, Benedetta Kumita, Janet R Barros, Teresa P Esbjorner, Elin K Luheshi, Leila M Crowther, Damian C Wilson, Mark R Dobson, Christopher M Favrin, Giorgio Yerbury, Justin J ANS binding reveals common features of cytotoxic amyloid species |
topic_facet |
binding reveals common features cytotoxic amyloid ans species CMMB Life Sciences Physical Sciences and Mathematics Social and Behavioral Sciences |
description |
Oligomeric assemblies formed from a variety of disease-associated peptides and proteins have been strongly associated with toxicity in many neurodegenerative conditions, such as Alzheimer's disease. The precise nature of the toxic agents, however, remains still to be established. We show that prefibrillar aggregates of E22G (arctic) variant of the A beta(1-42) peptide bind strongly to 1-anilinonaphthalene 8-sulfonate and that changes in this property correlate significantly with changes in its cytotoxicity. Moreover, we show that this phenomenon is common to other amyloid systems, such as wild-type A beta(1-42), the 159T variant of human lysozyme and an SH3 domain. These findings are consistent with a model in which the exposure of hydrophobic surfaces as a result of the aggregation of misfolded species is a crucial and common feature of these pathogenic species. |
format |
Article in Journal/Newspaper |
author |
Bolognesi, Benedetta Kumita, Janet R Barros, Teresa P Esbjorner, Elin K Luheshi, Leila M Crowther, Damian C Wilson, Mark R Dobson, Christopher M Favrin, Giorgio Yerbury, Justin J |
author_facet |
Bolognesi, Benedetta Kumita, Janet R Barros, Teresa P Esbjorner, Elin K Luheshi, Leila M Crowther, Damian C Wilson, Mark R Dobson, Christopher M Favrin, Giorgio Yerbury, Justin J |
author_sort |
Bolognesi, Benedetta |
title |
ANS binding reveals common features of cytotoxic amyloid species |
title_short |
ANS binding reveals common features of cytotoxic amyloid species |
title_full |
ANS binding reveals common features of cytotoxic amyloid species |
title_fullStr |
ANS binding reveals common features of cytotoxic amyloid species |
title_full_unstemmed |
ANS binding reveals common features of cytotoxic amyloid species |
title_sort |
ans binding reveals common features of cytotoxic amyloid species |
publisher |
Research Online |
publishDate |
2010 |
url |
https://ro.uow.edu.au/scipapers/974 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Faculty of Science - Papers (Archive) |
op_relation |
https://ro.uow.edu.au/scipapers/974 |
_version_ |
1766334982418071552 |