Xenobiotic-metabolizing enzymes and biotransformation of polybrominated diphenyl ether and polychlorinated biphenyl contaminants in beluga whales (Delphinapterus leucas) from the St. Lawrence River estuary and western Hudson Bay, Canada
The highly contaminated St. Lawrence Estuary beluga whale (SLB) population exhibits health problems and various pathologies possibly associated with pollutant exposure, which are not found in less exposed Canadian Arctic belugas (CAB). Biotransformation mediates contaminant fate and effects through...
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University of Windsor
2004
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ftunivwindsor:oai:scholar.uwindsor.ca:etd-5602 2023-06-11T04:09:35+02:00 Xenobiotic-metabolizing enzymes and biotransformation of polybrominated diphenyl ether and polychlorinated biphenyl contaminants in beluga whales (Delphinapterus leucas) from the St. Lawrence River estuary and western Hudson Bay, Canada McKinney, Melissa A. 2004-01-01T08:00:00Z application/pdf https://scholar.uwindsor.ca/etd/4603 https://scholar.uwindsor.ca/context/etd/article/5602/viewcontent/Xenobiotic_metabolizing_enzyme.pdf eng eng University of Windsor https://scholar.uwindsor.ca/etd/4603 https://scholar.uwindsor.ca/context/etd/article/5602/viewcontent/Xenobiotic_metabolizing_enzyme.pdf info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Electronic Theses and Dissertations Environmental Sciences info:eu-repo/semantics/masterThesis 2004 ftunivwindsor 2023-05-06T18:59:12Z The highly contaminated St. Lawrence Estuary beluga whale (SLB) population exhibits health problems and various pathologies possibly associated with pollutant exposure, which are not found in less exposed Canadian Arctic belugas (CAB). Biotransformation mediates contaminant fate and effects through conversion to less persistent, more excretable products (detoxification) and through formation of retained/persistent, secondary contaminants (bioactivation). In this thesis, the metabolic potential of these two differentially exposed beluga populations towards PCBs and PBDEs was investigated. Qualitatively similar hepatic xenobiotic-metabolizing enzyme profiles (cytochromes P4501A, 2B, 3A, 2E, epoxide hydrolase and UDP-glucuronosyl transferase) were immunochemically detected between SLB and CAB, indicating that CAB can be used to model contaminant biotransformation in the endangered SLB. The results suggest contaminant bioactivation through formation of retained/persistent and potentially toxic PCB (and possibly PBDE) metabolites. Evidence of possible bioactivation mechanisms via biotransformation supports the association between contaminant exposure and health problems in the endangered SLB population. (Abstract shortened by UMI.)Dept. of Chemistry and Biochemistry. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2004 .M355. Source: Masters Abstracts International, Volume: 43-05, page: 1689. Adviser: Robert Letcher. Thesis (M.Sc.)--University of Windsor (Canada), 2004. Master Thesis Arctic Beluga Beluga whale Beluga* Delphinapterus leucas Hudson Bay University of Windsor, Ontario: Scholarship at UWindsor Arctic Canada Hudson Hudson Bay Lawrence River ENVELOPE(-115.002,-115.002,58.384,58.384) Leddy ENVELOPE(-117.519,-117.519,56.367,56.367) |
institution |
Open Polar |
collection |
University of Windsor, Ontario: Scholarship at UWindsor |
op_collection_id |
ftunivwindsor |
language |
English |
topic |
Environmental Sciences |
spellingShingle |
Environmental Sciences McKinney, Melissa A. Xenobiotic-metabolizing enzymes and biotransformation of polybrominated diphenyl ether and polychlorinated biphenyl contaminants in beluga whales (Delphinapterus leucas) from the St. Lawrence River estuary and western Hudson Bay, Canada |
topic_facet |
Environmental Sciences |
description |
The highly contaminated St. Lawrence Estuary beluga whale (SLB) population exhibits health problems and various pathologies possibly associated with pollutant exposure, which are not found in less exposed Canadian Arctic belugas (CAB). Biotransformation mediates contaminant fate and effects through conversion to less persistent, more excretable products (detoxification) and through formation of retained/persistent, secondary contaminants (bioactivation). In this thesis, the metabolic potential of these two differentially exposed beluga populations towards PCBs and PBDEs was investigated. Qualitatively similar hepatic xenobiotic-metabolizing enzyme profiles (cytochromes P4501A, 2B, 3A, 2E, epoxide hydrolase and UDP-glucuronosyl transferase) were immunochemically detected between SLB and CAB, indicating that CAB can be used to model contaminant biotransformation in the endangered SLB. The results suggest contaminant bioactivation through formation of retained/persistent and potentially toxic PCB (and possibly PBDE) metabolites. Evidence of possible bioactivation mechanisms via biotransformation supports the association between contaminant exposure and health problems in the endangered SLB population. (Abstract shortened by UMI.)Dept. of Chemistry and Biochemistry. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2004 .M355. Source: Masters Abstracts International, Volume: 43-05, page: 1689. Adviser: Robert Letcher. Thesis (M.Sc.)--University of Windsor (Canada), 2004. |
format |
Master Thesis |
author |
McKinney, Melissa A. |
author_facet |
McKinney, Melissa A. |
author_sort |
McKinney, Melissa A. |
title |
Xenobiotic-metabolizing enzymes and biotransformation of polybrominated diphenyl ether and polychlorinated biphenyl contaminants in beluga whales (Delphinapterus leucas) from the St. Lawrence River estuary and western Hudson Bay, Canada |
title_short |
Xenobiotic-metabolizing enzymes and biotransformation of polybrominated diphenyl ether and polychlorinated biphenyl contaminants in beluga whales (Delphinapterus leucas) from the St. Lawrence River estuary and western Hudson Bay, Canada |
title_full |
Xenobiotic-metabolizing enzymes and biotransformation of polybrominated diphenyl ether and polychlorinated biphenyl contaminants in beluga whales (Delphinapterus leucas) from the St. Lawrence River estuary and western Hudson Bay, Canada |
title_fullStr |
Xenobiotic-metabolizing enzymes and biotransformation of polybrominated diphenyl ether and polychlorinated biphenyl contaminants in beluga whales (Delphinapterus leucas) from the St. Lawrence River estuary and western Hudson Bay, Canada |
title_full_unstemmed |
Xenobiotic-metabolizing enzymes and biotransformation of polybrominated diphenyl ether and polychlorinated biphenyl contaminants in beluga whales (Delphinapterus leucas) from the St. Lawrence River estuary and western Hudson Bay, Canada |
title_sort |
xenobiotic-metabolizing enzymes and biotransformation of polybrominated diphenyl ether and polychlorinated biphenyl contaminants in beluga whales (delphinapterus leucas) from the st. lawrence river estuary and western hudson bay, canada |
publisher |
University of Windsor |
publishDate |
2004 |
url |
https://scholar.uwindsor.ca/etd/4603 https://scholar.uwindsor.ca/context/etd/article/5602/viewcontent/Xenobiotic_metabolizing_enzyme.pdf |
long_lat |
ENVELOPE(-115.002,-115.002,58.384,58.384) ENVELOPE(-117.519,-117.519,56.367,56.367) |
geographic |
Arctic Canada Hudson Hudson Bay Lawrence River Leddy |
geographic_facet |
Arctic Canada Hudson Hudson Bay Lawrence River Leddy |
genre |
Arctic Beluga Beluga whale Beluga* Delphinapterus leucas Hudson Bay |
genre_facet |
Arctic Beluga Beluga whale Beluga* Delphinapterus leucas Hudson Bay |
op_source |
Electronic Theses and Dissertations |
op_relation |
https://scholar.uwindsor.ca/etd/4603 https://scholar.uwindsor.ca/context/etd/article/5602/viewcontent/Xenobiotic_metabolizing_enzyme.pdf |
op_rights |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ |
_version_ |
1768383538092048384 |