Rare ATGL Haplotypes Are Associated with Increased Plasma Triglyceride Concentrations in the Greenland Inuit
Objectives. To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit. Study design. Candidate gene association study of discrete and quantitative traits related to cardiovasc...
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ftunivwestonta:oai:ir.lib.uwo.ca:vascularpub-1042 2023-10-01T03:56:12+02:00 Rare ATGL Haplotypes Are Associated with Increased Plasma Triglyceride Concentrations in the Greenland Inuit Johansen, Christopher T. Gallinger, Zane R. Wang, Jian Ban, Matthew R. Young, T. Kue Bjerregaard, Peter Hegele, Robert A. 2010-02-01T08:00:00Z https://ir.lib.uwo.ca/vascularpub/43 http://ijch.fi/issues/691/69_1_johansen_abstract.html unknown Scholarship@Western https://ir.lib.uwo.ca/vascularpub/43 http://ijch.fi/issues/691/69_1_johansen_abstract.html Robarts Vascular Research Publications adipose triglyceride lipase cardiovascular disease genetic association study haplo- type analysis single nucleotide polymorphisms triglyceride-rich lipoproteins Cardiology article 2010 ftunivwestonta 2023-09-03T06:50:52Z Objectives. To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit. Study design. Candidate gene association study of discrete and quantitative traits related to cardiovascular health. Methods. ATGL was sequenced in 10 European subjects to identify DNA sequence variants. The identified polymorphisms were subsequently genotyped in a population-based cohort of 1,218 unrelated Greenland Inuit subjects, ascertained from the Greenland Population Study. Genotypes and reconstructed haplotypes were tested for association with cardiovascular disease risk factors using additive, dominant or recessive models, corrected for age, sex and body mass index. Results. Five single nucleotide polymorphisms and one 4-base pair deletion were identified in the European sample and were similarly polymorphic in the Greenland Inuit. Independently, variants were not associated with any cardiovascular traits. However, reconstructed rare ATGL haplotypes were associated with increased plasma triglyceride (TG) concentrations compared to the major haplotype under a dominant model (1.21 +/-0.7 mmol/L and 1.11 +/-0.6 mmol/L, respectively, p=0.006). Conclusions. Rare ATGL haplotypes are associated with increased plasma TG concentrations in the Greenland Inuit. Article in Journal/Newspaper Greenland inuit The University of Western Ontario: Scholarship@Western Greenland |
institution |
Open Polar |
collection |
The University of Western Ontario: Scholarship@Western |
op_collection_id |
ftunivwestonta |
language |
unknown |
topic |
adipose triglyceride lipase cardiovascular disease genetic association study haplo- type analysis single nucleotide polymorphisms triglyceride-rich lipoproteins Cardiology |
spellingShingle |
adipose triglyceride lipase cardiovascular disease genetic association study haplo- type analysis single nucleotide polymorphisms triglyceride-rich lipoproteins Cardiology Johansen, Christopher T. Gallinger, Zane R. Wang, Jian Ban, Matthew R. Young, T. Kue Bjerregaard, Peter Hegele, Robert A. Rare ATGL Haplotypes Are Associated with Increased Plasma Triglyceride Concentrations in the Greenland Inuit |
topic_facet |
adipose triglyceride lipase cardiovascular disease genetic association study haplo- type analysis single nucleotide polymorphisms triglyceride-rich lipoproteins Cardiology |
description |
Objectives. To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit. Study design. Candidate gene association study of discrete and quantitative traits related to cardiovascular health. Methods. ATGL was sequenced in 10 European subjects to identify DNA sequence variants. The identified polymorphisms were subsequently genotyped in a population-based cohort of 1,218 unrelated Greenland Inuit subjects, ascertained from the Greenland Population Study. Genotypes and reconstructed haplotypes were tested for association with cardiovascular disease risk factors using additive, dominant or recessive models, corrected for age, sex and body mass index. Results. Five single nucleotide polymorphisms and one 4-base pair deletion were identified in the European sample and were similarly polymorphic in the Greenland Inuit. Independently, variants were not associated with any cardiovascular traits. However, reconstructed rare ATGL haplotypes were associated with increased plasma triglyceride (TG) concentrations compared to the major haplotype under a dominant model (1.21 +/-0.7 mmol/L and 1.11 +/-0.6 mmol/L, respectively, p=0.006). Conclusions. Rare ATGL haplotypes are associated with increased plasma TG concentrations in the Greenland Inuit. |
format |
Article in Journal/Newspaper |
author |
Johansen, Christopher T. Gallinger, Zane R. Wang, Jian Ban, Matthew R. Young, T. Kue Bjerregaard, Peter Hegele, Robert A. |
author_facet |
Johansen, Christopher T. Gallinger, Zane R. Wang, Jian Ban, Matthew R. Young, T. Kue Bjerregaard, Peter Hegele, Robert A. |
author_sort |
Johansen, Christopher T. |
title |
Rare ATGL Haplotypes Are Associated with Increased Plasma Triglyceride Concentrations in the Greenland Inuit |
title_short |
Rare ATGL Haplotypes Are Associated with Increased Plasma Triglyceride Concentrations in the Greenland Inuit |
title_full |
Rare ATGL Haplotypes Are Associated with Increased Plasma Triglyceride Concentrations in the Greenland Inuit |
title_fullStr |
Rare ATGL Haplotypes Are Associated with Increased Plasma Triglyceride Concentrations in the Greenland Inuit |
title_full_unstemmed |
Rare ATGL Haplotypes Are Associated with Increased Plasma Triglyceride Concentrations in the Greenland Inuit |
title_sort |
rare atgl haplotypes are associated with increased plasma triglyceride concentrations in the greenland inuit |
publisher |
Scholarship@Western |
publishDate |
2010 |
url |
https://ir.lib.uwo.ca/vascularpub/43 http://ijch.fi/issues/691/69_1_johansen_abstract.html |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_source |
Robarts Vascular Research Publications |
op_relation |
https://ir.lib.uwo.ca/vascularpub/43 http://ijch.fi/issues/691/69_1_johansen_abstract.html |
_version_ |
1778525535461179392 |