Association between the FTO rs9939609 Polymorphism and the Metabolic Syndrome in a Non-Caucasian Multi-ethnic Sample
Background: The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Cauc...
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ftunivwestonta:oai:ir.lib.uwo.ca:vascularpub-1003 2023-10-01T03:57:02+02:00 Association between the FTO rs9939609 Polymorphism and the Metabolic Syndrome in a Non-Caucasian Multi-ethnic Sample Al-Attar, Salam A. Pollex, Rebecca L. Ban, Matthew R. Young, T Kue Bjerregaard, Peter Anand, Sonia S. Yusuf, Salim Zinman, Bernard Harris, Stewart B. Hanley, Anthony J. G. Connelly, Philip W. Huff, Murray W. Hegele, Robert A. 2008-03-13T07:00:00Z https://ir.lib.uwo.ca/vascularpub/4 http://www.cardiab.com/content/7/1/5 unknown Scholarship@Western https://ir.lib.uwo.ca/vascularpub/4 http://www.cardiab.com/content/7/1/5 Robarts Vascular Research Publications Adult Asian Continental Ancestry Group Body Size Canada Cholesterol HDL Female Gene Frequency Genetic Predisposition to Disease Humans Indians North American Inuits Male Metabolic Syndrome X Middle Aged Odds Ratio Phenotype Polymorphism Single Nucleotide Proteins Risk Assessment Risk Factors Sex Factors Cardiology Medical Genetics Medical Microbiology article 2008 ftunivwestonta 2023-09-03T06:49:39Z Background: The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples. Methods: The FTO rs9939609 SNP was genotyped in 2121 subjects from four different non-Caucasian geographical ancestries. Subjects were classified for the presence or absence of MetS according to the International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel (NCEP ATP) III definitions. Results: Carriers of > or = 1 copy of the rs9939609 A allele were significantly more likely to have IDF-defined MetS (35.8%) than non-carriers (31.2%), corresponding to a carrier odds ratio (OR) of 1.23 (95% confidence interval [CI] 1.01 to 1.50), with a similar trend for the NCEP ATP III-defined MetS. Subgroup analysis showed that the association was particularly strong in men. The association was related to a higher proportion of rs9939609 A allele carriers meeting the waist circumference criterion; a higher proportion also met the HDL cholesterol criterion compared with wild-type homozygotes. Conclusion: Thus, the FTO rs9939609 SNP was associated with an increased risk for MetS in this multi-ethnic sample, confirming that the association extends to non-Caucasian population samples. Article in Journal/Newspaper inuits The University of Western Ontario: Scholarship@Western Canada The Waist ENVELOPE(-61.404,-61.404,-64.639,-64.639) |
institution |
Open Polar |
collection |
The University of Western Ontario: Scholarship@Western |
op_collection_id |
ftunivwestonta |
language |
unknown |
topic |
Adult Asian Continental Ancestry Group Body Size Canada Cholesterol HDL Female Gene Frequency Genetic Predisposition to Disease Humans Indians North American Inuits Male Metabolic Syndrome X Middle Aged Odds Ratio Phenotype Polymorphism Single Nucleotide Proteins Risk Assessment Risk Factors Sex Factors Cardiology Medical Genetics Medical Microbiology |
spellingShingle |
Adult Asian Continental Ancestry Group Body Size Canada Cholesterol HDL Female Gene Frequency Genetic Predisposition to Disease Humans Indians North American Inuits Male Metabolic Syndrome X Middle Aged Odds Ratio Phenotype Polymorphism Single Nucleotide Proteins Risk Assessment Risk Factors Sex Factors Cardiology Medical Genetics Medical Microbiology Al-Attar, Salam A. Pollex, Rebecca L. Ban, Matthew R. Young, T Kue Bjerregaard, Peter Anand, Sonia S. Yusuf, Salim Zinman, Bernard Harris, Stewart B. Hanley, Anthony J. G. Connelly, Philip W. Huff, Murray W. Hegele, Robert A. Association between the FTO rs9939609 Polymorphism and the Metabolic Syndrome in a Non-Caucasian Multi-ethnic Sample |
topic_facet |
Adult Asian Continental Ancestry Group Body Size Canada Cholesterol HDL Female Gene Frequency Genetic Predisposition to Disease Humans Indians North American Inuits Male Metabolic Syndrome X Middle Aged Odds Ratio Phenotype Polymorphism Single Nucleotide Proteins Risk Assessment Risk Factors Sex Factors Cardiology Medical Genetics Medical Microbiology |
description |
Background: The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples. Methods: The FTO rs9939609 SNP was genotyped in 2121 subjects from four different non-Caucasian geographical ancestries. Subjects were classified for the presence or absence of MetS according to the International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel (NCEP ATP) III definitions. Results: Carriers of > or = 1 copy of the rs9939609 A allele were significantly more likely to have IDF-defined MetS (35.8%) than non-carriers (31.2%), corresponding to a carrier odds ratio (OR) of 1.23 (95% confidence interval [CI] 1.01 to 1.50), with a similar trend for the NCEP ATP III-defined MetS. Subgroup analysis showed that the association was particularly strong in men. The association was related to a higher proportion of rs9939609 A allele carriers meeting the waist circumference criterion; a higher proportion also met the HDL cholesterol criterion compared with wild-type homozygotes. Conclusion: Thus, the FTO rs9939609 SNP was associated with an increased risk for MetS in this multi-ethnic sample, confirming that the association extends to non-Caucasian population samples. |
format |
Article in Journal/Newspaper |
author |
Al-Attar, Salam A. Pollex, Rebecca L. Ban, Matthew R. Young, T Kue Bjerregaard, Peter Anand, Sonia S. Yusuf, Salim Zinman, Bernard Harris, Stewart B. Hanley, Anthony J. G. Connelly, Philip W. Huff, Murray W. Hegele, Robert A. |
author_facet |
Al-Attar, Salam A. Pollex, Rebecca L. Ban, Matthew R. Young, T Kue Bjerregaard, Peter Anand, Sonia S. Yusuf, Salim Zinman, Bernard Harris, Stewart B. Hanley, Anthony J. G. Connelly, Philip W. Huff, Murray W. Hegele, Robert A. |
author_sort |
Al-Attar, Salam A. |
title |
Association between the FTO rs9939609 Polymorphism and the Metabolic Syndrome in a Non-Caucasian Multi-ethnic Sample |
title_short |
Association between the FTO rs9939609 Polymorphism and the Metabolic Syndrome in a Non-Caucasian Multi-ethnic Sample |
title_full |
Association between the FTO rs9939609 Polymorphism and the Metabolic Syndrome in a Non-Caucasian Multi-ethnic Sample |
title_fullStr |
Association between the FTO rs9939609 Polymorphism and the Metabolic Syndrome in a Non-Caucasian Multi-ethnic Sample |
title_full_unstemmed |
Association between the FTO rs9939609 Polymorphism and the Metabolic Syndrome in a Non-Caucasian Multi-ethnic Sample |
title_sort |
association between the fto rs9939609 polymorphism and the metabolic syndrome in a non-caucasian multi-ethnic sample |
publisher |
Scholarship@Western |
publishDate |
2008 |
url |
https://ir.lib.uwo.ca/vascularpub/4 http://www.cardiab.com/content/7/1/5 |
long_lat |
ENVELOPE(-61.404,-61.404,-64.639,-64.639) |
geographic |
Canada The Waist |
geographic_facet |
Canada The Waist |
genre |
inuits |
genre_facet |
inuits |
op_source |
Robarts Vascular Research Publications |
op_relation |
https://ir.lib.uwo.ca/vascularpub/4 http://www.cardiab.com/content/7/1/5 |
_version_ |
1778527928833802240 |