Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population
Background: We investigated the associations among cardiovascular risk factors, carotid atherosclerosis and cognitive function in a Canadian First Nations population. Methods: Individuals aged ≥18 years, without stroke, nonpreg- nant and with First Nations status were assessed by the Trail Making Te...
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2009
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Online Access: | https://ir.lib.uwo.ca/medpub/263 https://doi.org/10.1159/000254294 https://ir.lib.uwo.ca/context/medpub/article/1270/viewcontent/Carotid_20atherosclerosis_20and_20a_20reduced_20likelihood_20for_20lowered_20cognitive_20Performance_20in_20a_20Canadian_20first_20nations_20population.pdf |
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ftunivwestonta:oai:ir.lib.uwo.ca:medpub-1270 2023-10-01T03:55:59+02:00 Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population Fergenbaum, J. H. Bruce, S. Spence, J. D. Lou, W. Hanley, A. J.G. Greenwood, C. Young, T. K. 2009-01-01T08:00:00Z application/pdf https://ir.lib.uwo.ca/medpub/263 https://doi.org/10.1159/000254294 https://ir.lib.uwo.ca/context/medpub/article/1270/viewcontent/Carotid_20atherosclerosis_20and_20a_20reduced_20likelihood_20for_20lowered_20cognitive_20Performance_20in_20a_20Canadian_20first_20nations_20population.pdf unknown Scholarship@Western https://ir.lib.uwo.ca/medpub/263 doi:10.1159/000254294 https://ir.lib.uwo.ca/context/medpub/article/1270/viewcontent/Carotid_20atherosclerosis_20and_20a_20reduced_20likelihood_20for_20lowered_20cognitive_20Performance_20in_20a_20Canadian_20first_20nations_20population.pdf Department of Medicine Publications Anthropometric risk factors Carotid stenosis Cognitive function Executive function Native Americans conference 2009 ftunivwestonta https://doi.org/10.1159/000254294 2023-09-03T07:12:54Z Background: We investigated the associations among cardiovascular risk factors, carotid atherosclerosis and cognitive function in a Canadian First Nations population. Methods: Individuals aged ≥18 years, without stroke, nonpreg- nant and with First Nations status were assessed by the Trail Making Test Parts A and B. Results were combined into a Trail Making Test executive function score (TMT-exec). Doppler ultrasonography assessed carotid stenosis and plaque volume. Anthropometric, vascular and metabolic risk factors were assessed by interview, clinical examinations and blood tests. Results: For 190 individuals with TMT-exec scores, the median age of the population was 39 years. Compared to the reference group, individuals with elevated levels of left carotid stenosis (LCS) and total carotid stenosis (TCS) were less likely to demonstrate lowered cognitive performance [LCS, odds ratio (OR): 0.47, 95% confidence interval (CI): 0.24-0.96; TCS, OR: 0.40, 95% CI: 0.20-0.80]. No effect was shown for plaque volume. In structural equation modeling, we found that for every 1-unit change in the anthropometric factor in kg/m2, there was a 0.86-fold decrease in the percent of TCS (p < 0.05). Conclusions: Individuals with elevated levels of LCS and TCS were less likely to demonstrate lowered performance. There was some suggestion that TCS mediates the effect of anthropometric risk factors on cognitive function. Copyright © 2009 S. Karger AG, Basel. Conference Object First Nations The University of Western Ontario: Scholarship@Western Neuroepidemiology 33 4 321 328 |
institution |
Open Polar |
collection |
The University of Western Ontario: Scholarship@Western |
op_collection_id |
ftunivwestonta |
language |
unknown |
topic |
Anthropometric risk factors Carotid stenosis Cognitive function Executive function Native Americans |
spellingShingle |
Anthropometric risk factors Carotid stenosis Cognitive function Executive function Native Americans Fergenbaum, J. H. Bruce, S. Spence, J. D. Lou, W. Hanley, A. J.G. Greenwood, C. Young, T. K. Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population |
topic_facet |
Anthropometric risk factors Carotid stenosis Cognitive function Executive function Native Americans |
description |
Background: We investigated the associations among cardiovascular risk factors, carotid atherosclerosis and cognitive function in a Canadian First Nations population. Methods: Individuals aged ≥18 years, without stroke, nonpreg- nant and with First Nations status were assessed by the Trail Making Test Parts A and B. Results were combined into a Trail Making Test executive function score (TMT-exec). Doppler ultrasonography assessed carotid stenosis and plaque volume. Anthropometric, vascular and metabolic risk factors were assessed by interview, clinical examinations and blood tests. Results: For 190 individuals with TMT-exec scores, the median age of the population was 39 years. Compared to the reference group, individuals with elevated levels of left carotid stenosis (LCS) and total carotid stenosis (TCS) were less likely to demonstrate lowered cognitive performance [LCS, odds ratio (OR): 0.47, 95% confidence interval (CI): 0.24-0.96; TCS, OR: 0.40, 95% CI: 0.20-0.80]. No effect was shown for plaque volume. In structural equation modeling, we found that for every 1-unit change in the anthropometric factor in kg/m2, there was a 0.86-fold decrease in the percent of TCS (p < 0.05). Conclusions: Individuals with elevated levels of LCS and TCS were less likely to demonstrate lowered performance. There was some suggestion that TCS mediates the effect of anthropometric risk factors on cognitive function. Copyright © 2009 S. Karger AG, Basel. |
format |
Conference Object |
author |
Fergenbaum, J. H. Bruce, S. Spence, J. D. Lou, W. Hanley, A. J.G. Greenwood, C. Young, T. K. |
author_facet |
Fergenbaum, J. H. Bruce, S. Spence, J. D. Lou, W. Hanley, A. J.G. Greenwood, C. Young, T. K. |
author_sort |
Fergenbaum, J. H. |
title |
Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population |
title_short |
Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population |
title_full |
Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population |
title_fullStr |
Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population |
title_full_unstemmed |
Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population |
title_sort |
carotid atherosclerosis and a reduced likelihood for lowered cognitive performance in a canadian first nations population |
publisher |
Scholarship@Western |
publishDate |
2009 |
url |
https://ir.lib.uwo.ca/medpub/263 https://doi.org/10.1159/000254294 https://ir.lib.uwo.ca/context/medpub/article/1270/viewcontent/Carotid_20atherosclerosis_20and_20a_20reduced_20likelihood_20for_20lowered_20cognitive_20Performance_20in_20a_20Canadian_20first_20nations_20population.pdf |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Department of Medicine Publications |
op_relation |
https://ir.lib.uwo.ca/medpub/263 doi:10.1159/000254294 https://ir.lib.uwo.ca/context/medpub/article/1270/viewcontent/Carotid_20atherosclerosis_20and_20a_20reduced_20likelihood_20for_20lowered_20cognitive_20Performance_20in_20a_20Canadian_20first_20nations_20population.pdf |
op_doi |
https://doi.org/10.1159/000254294 |
container_title |
Neuroepidemiology |
container_volume |
33 |
container_issue |
4 |
container_start_page |
321 |
op_container_end_page |
328 |
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1778524949293563904 |