Growth Characteristics and Lipid Metabolism of Cultured Migratory Bird Skeletal Muscle Cells
Diets rich in n-3 polyunsaturated fatty acids (PUFA) may alter the muscle metabolism of migratory birds, improving their endurance performance. I established and validated for the first time in vitro muscle models of a migratory songbird (yellow-rumped warbler, Setophaga coronata coronata) and shore...
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ftunivwestonta:oai:ir.lib.uwo.ca:etd-8410 2023-10-01T03:55:12+02:00 Growth Characteristics and Lipid Metabolism of Cultured Migratory Bird Skeletal Muscle Cells Young, Kevin G 2019-04-18T22:00:00Z application/pdf https://ir.lib.uwo.ca/etd/6154 https://ir.lib.uwo.ca/context/etd/article/8410/viewcontent/Thesis_KGY_postdefense_finalfinalfinalfinal.pdf English eng Scholarship@Western https://ir.lib.uwo.ca/etd/6154 https://ir.lib.uwo.ca/context/etd/article/8410/viewcontent/Thesis_KGY_postdefense_finalfinalfinalfinal.pdf Electronic Thesis and Dissertation Repository migration avian cell culture satellite cell lipid metabolism muscle metabolism polyunsaturated fatty acid Comparative and Evolutionary Physiology text 2019 ftunivwestonta 2023-09-03T07:31:05Z Diets rich in n-3 polyunsaturated fatty acids (PUFA) may alter the muscle metabolism of migratory birds, improving their endurance performance. I established and validated for the first time in vitro muscle models of a migratory songbird (yellow-rumped warbler, Setophaga coronata coronata) and shorebird (sanderling, Calidris alba). To evaluate the role of n-3 PUFA in improving fatty acid metabolism in migratory bird muscle, I measured metabolic outcomes following n-3 PUFA supplementation in these two avian cell types and a murine (Mus musculus, C2C12) cell line. PUFA supplementation in C2C12 cells increased metabolic transcription factor expression and increased mitochondrial respiratory chain efficiency. Migrant bird muscle cells did not display the same changes in transcriptional signaling, but sanderling cells increased basal and maximal oxygen consumption with n-3 PUFA supplementation. This research provides support for the hypothesis that n-3 PUFA increase aerobic capacity of a migrant sandpiper and efficiency in mammalian skeletal muscle. Text Calidris alba Sanderling The University of Western Ontario: Scholarship@Western |
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Open Polar |
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The University of Western Ontario: Scholarship@Western |
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ftunivwestonta |
language |
English |
topic |
migration avian cell culture satellite cell lipid metabolism muscle metabolism polyunsaturated fatty acid Comparative and Evolutionary Physiology |
spellingShingle |
migration avian cell culture satellite cell lipid metabolism muscle metabolism polyunsaturated fatty acid Comparative and Evolutionary Physiology Young, Kevin G Growth Characteristics and Lipid Metabolism of Cultured Migratory Bird Skeletal Muscle Cells |
topic_facet |
migration avian cell culture satellite cell lipid metabolism muscle metabolism polyunsaturated fatty acid Comparative and Evolutionary Physiology |
description |
Diets rich in n-3 polyunsaturated fatty acids (PUFA) may alter the muscle metabolism of migratory birds, improving their endurance performance. I established and validated for the first time in vitro muscle models of a migratory songbird (yellow-rumped warbler, Setophaga coronata coronata) and shorebird (sanderling, Calidris alba). To evaluate the role of n-3 PUFA in improving fatty acid metabolism in migratory bird muscle, I measured metabolic outcomes following n-3 PUFA supplementation in these two avian cell types and a murine (Mus musculus, C2C12) cell line. PUFA supplementation in C2C12 cells increased metabolic transcription factor expression and increased mitochondrial respiratory chain efficiency. Migrant bird muscle cells did not display the same changes in transcriptional signaling, but sanderling cells increased basal and maximal oxygen consumption with n-3 PUFA supplementation. This research provides support for the hypothesis that n-3 PUFA increase aerobic capacity of a migrant sandpiper and efficiency in mammalian skeletal muscle. |
format |
Text |
author |
Young, Kevin G |
author_facet |
Young, Kevin G |
author_sort |
Young, Kevin G |
title |
Growth Characteristics and Lipid Metabolism of Cultured Migratory Bird Skeletal Muscle Cells |
title_short |
Growth Characteristics and Lipid Metabolism of Cultured Migratory Bird Skeletal Muscle Cells |
title_full |
Growth Characteristics and Lipid Metabolism of Cultured Migratory Bird Skeletal Muscle Cells |
title_fullStr |
Growth Characteristics and Lipid Metabolism of Cultured Migratory Bird Skeletal Muscle Cells |
title_full_unstemmed |
Growth Characteristics and Lipid Metabolism of Cultured Migratory Bird Skeletal Muscle Cells |
title_sort |
growth characteristics and lipid metabolism of cultured migratory bird skeletal muscle cells |
publisher |
Scholarship@Western |
publishDate |
2019 |
url |
https://ir.lib.uwo.ca/etd/6154 https://ir.lib.uwo.ca/context/etd/article/8410/viewcontent/Thesis_KGY_postdefense_finalfinalfinalfinal.pdf |
genre |
Calidris alba Sanderling |
genre_facet |
Calidris alba Sanderling |
op_source |
Electronic Thesis and Dissertation Repository |
op_relation |
https://ir.lib.uwo.ca/etd/6154 https://ir.lib.uwo.ca/context/etd/article/8410/viewcontent/Thesis_KGY_postdefense_finalfinalfinalfinal.pdf |
_version_ |
1778523466462396416 |