Exploring anti-tyrosinase bioactive compounds from the Cape flora
>Magister Scientiae - MSc Tyrosinase is an enzyme widely distributed in the biosphere and is found in many species of bacteria, fungi, animals, and plants; it is associated with melanin production. Even though it possesses many beneficial properties such as photoprotection, but overproduction cau...
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University of the Western Cape
2018
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ftunivwesterncap:oai:etd.uwc.ac.za:11394/6531 2023-05-15T14:02:11+02:00 Exploring anti-tyrosinase bioactive compounds from the Cape flora Sonka, Luveni Mohammed, Ahmed H.A 2018 http://hdl.handle.net/11394/6531 en eng University of the Western Cape http://hdl.handle.net/11394/6531 University of the Western Cape CFR M. quercifolia TLC bioautography Tyrosinase Inhibition Melanoma B16- F10 Melanin biosynthesis inhibition Depigmentation cosmetics 2018 ftunivwesterncap 2021-06-17T16:11:37Z >Magister Scientiae - MSc Tyrosinase is an enzyme widely distributed in the biosphere and is found in many species of bacteria, fungi, animals, and plants; it is associated with melanin production. Even though it possesses many beneficial properties such as photoprotection, but overproduction causes undesirable effects such melasma, solar lentigines etc. Therefore, tyrosinase enzyme inhibitors are of far-ranging importance in cosmetics, medicinal products, and food industries. This study is aimed to test anti-tyrosinase activity in 37 plants from 20 families using mushroom tyrosinase inhibition method; each plant was extracted with methanol. The results showed that 17 plant extracts, exerted a considerable level of in vitro tyrosinase inhibition comparable to positive controls of kojic acid in the same solvent systems when evaluated spectrophotometrically. Among plant extracts, those that showed an inhibition rate >50 % at 50 μg/ml and ˃60 % at 200 μg/ml were A. karroo (Hayne.), A. afra Jacq. Ex Willd, C. geifolia (L.), E. racemosa (L.), H. petiolare Hilliard & B.L.Burt, M. quercifolia (L.), M. communis (L.), P. rigida (Wikstr.), P. ecklonii (Benth.), P. ericoides (L.), S. Africanacaerulea (L.), S. Africana-lutea (L.), S. antarcticus (Willd.), S. lucida (L.) F.A.Barkley, S. hamilifolius (L.), S. furcellata R.Br and T riparia which exhibited great anti-tyrosinase activity. Other/Unknown Material Antarc* antarcticus University of the Western Cape: Electronic Thesis and Dissertation Library Hayne ENVELOPE(65.030,65.030,-70.279,-70.279) |
institution |
Open Polar |
collection |
University of the Western Cape: Electronic Thesis and Dissertation Library |
op_collection_id |
ftunivwesterncap |
language |
English |
topic |
CFR M. quercifolia TLC bioautography Tyrosinase Inhibition Melanoma B16- F10 Melanin biosynthesis inhibition Depigmentation cosmetics |
spellingShingle |
CFR M. quercifolia TLC bioautography Tyrosinase Inhibition Melanoma B16- F10 Melanin biosynthesis inhibition Depigmentation cosmetics Sonka, Luveni Exploring anti-tyrosinase bioactive compounds from the Cape flora |
topic_facet |
CFR M. quercifolia TLC bioautography Tyrosinase Inhibition Melanoma B16- F10 Melanin biosynthesis inhibition Depigmentation cosmetics |
description |
>Magister Scientiae - MSc Tyrosinase is an enzyme widely distributed in the biosphere and is found in many species of bacteria, fungi, animals, and plants; it is associated with melanin production. Even though it possesses many beneficial properties such as photoprotection, but overproduction causes undesirable effects such melasma, solar lentigines etc. Therefore, tyrosinase enzyme inhibitors are of far-ranging importance in cosmetics, medicinal products, and food industries. This study is aimed to test anti-tyrosinase activity in 37 plants from 20 families using mushroom tyrosinase inhibition method; each plant was extracted with methanol. The results showed that 17 plant extracts, exerted a considerable level of in vitro tyrosinase inhibition comparable to positive controls of kojic acid in the same solvent systems when evaluated spectrophotometrically. Among plant extracts, those that showed an inhibition rate >50 % at 50 μg/ml and ˃60 % at 200 μg/ml were A. karroo (Hayne.), A. afra Jacq. Ex Willd, C. geifolia (L.), E. racemosa (L.), H. petiolare Hilliard & B.L.Burt, M. quercifolia (L.), M. communis (L.), P. rigida (Wikstr.), P. ecklonii (Benth.), P. ericoides (L.), S. Africanacaerulea (L.), S. Africana-lutea (L.), S. antarcticus (Willd.), S. lucida (L.) F.A.Barkley, S. hamilifolius (L.), S. furcellata R.Br and T riparia which exhibited great anti-tyrosinase activity. |
author2 |
Mohammed, Ahmed H.A |
author |
Sonka, Luveni |
author_facet |
Sonka, Luveni |
author_sort |
Sonka, Luveni |
title |
Exploring anti-tyrosinase bioactive compounds from the Cape flora |
title_short |
Exploring anti-tyrosinase bioactive compounds from the Cape flora |
title_full |
Exploring anti-tyrosinase bioactive compounds from the Cape flora |
title_fullStr |
Exploring anti-tyrosinase bioactive compounds from the Cape flora |
title_full_unstemmed |
Exploring anti-tyrosinase bioactive compounds from the Cape flora |
title_sort |
exploring anti-tyrosinase bioactive compounds from the cape flora |
publisher |
University of the Western Cape |
publishDate |
2018 |
url |
http://hdl.handle.net/11394/6531 |
long_lat |
ENVELOPE(65.030,65.030,-70.279,-70.279) |
geographic |
Hayne |
geographic_facet |
Hayne |
genre |
Antarc* antarcticus |
genre_facet |
Antarc* antarcticus |
op_relation |
http://hdl.handle.net/11394/6531 |
op_rights |
University of the Western Cape |
_version_ |
1766272300956516352 |