PAFAH1B1 and NDEL1 in the Cetartiodactyla superorder: Investigating adaptive evolution in two cerebral gyrification genes in Orcinus orca and Tursiops truncatus
Cerebral gyrencephaly, distinguished by the convoluted folds and grooves in the cerebral cortex, occurs in many animals in Class Mammalia. The highest rates of cerebral gyrification occur in Order Cetacea within the Superorder Cetartiodactyla. Of all cetaceans, two members of Family Delphinidae, Orc...
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Friday Harbor Laboratories
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ftunivwashington:oai:digital.lib.washington.edu:1773/27182 2023-05-15T17:53:15+02:00 PAFAH1B1 and NDEL1 in the Cetartiodactyla superorder: Investigating adaptive evolution in two cerebral gyrification genes in Orcinus orca and Tursiops truncatus Haas, David 2013-06 http://hdl.handle.net/1773/27182 en_US eng Friday Harbor Laboratories Marine Genomics Research Apprenticeship;Spring, 2013 http://hdl.handle.net/1773/27182 gyrencephaly cetartiodactyla cetaceans delphinidae Orcinus orca Tursiops truncatus PAFAH1B1 NDEL1 adaptive evolution positive selection purifying selection Other 2013 ftunivwashington 2023-03-12T18:51:59Z Cerebral gyrencephaly, distinguished by the convoluted folds and grooves in the cerebral cortex, occurs in many animals in Class Mammalia. The highest rates of cerebral gyrification occur in Order Cetacea within the Superorder Cetartiodactyla. Of all cetaceans, two members of Family Delphinidae, Orcinus orca (killer whales) and Tursiops truncatus (Atlantic bottlenose dolphins) have exceptionally high indices of cerebral gyrification. Research has shown that mutation in two genes, PAFAH1B1 and NDEL1, both located on human chromosome 17, disrupt gyrencephaly normally observed in human brains. Based on this research, PAFAH1B1 and NDEL1 were evaluated for positive selection in Orcinus orca and Tursiops truncatus, to test the hypothesis that these genes are undergoing adaptive evolution against the background of purifying selection. The results of multiple selection tests supported a set of null hypotheses, indicating that these genes were under purifying, not positive, selection, which supports the hypothesis that delphinid cerebral gyrification is not under the control of either PAFAH1B1 or NDEL1. Other/Unknown Material Orca Orcinus orca University of Washington, Seattle: ResearchWorks |
institution |
Open Polar |
collection |
University of Washington, Seattle: ResearchWorks |
op_collection_id |
ftunivwashington |
language |
English |
topic |
gyrencephaly cetartiodactyla cetaceans delphinidae Orcinus orca Tursiops truncatus PAFAH1B1 NDEL1 adaptive evolution positive selection purifying selection |
spellingShingle |
gyrencephaly cetartiodactyla cetaceans delphinidae Orcinus orca Tursiops truncatus PAFAH1B1 NDEL1 adaptive evolution positive selection purifying selection Haas, David PAFAH1B1 and NDEL1 in the Cetartiodactyla superorder: Investigating adaptive evolution in two cerebral gyrification genes in Orcinus orca and Tursiops truncatus |
topic_facet |
gyrencephaly cetartiodactyla cetaceans delphinidae Orcinus orca Tursiops truncatus PAFAH1B1 NDEL1 adaptive evolution positive selection purifying selection |
description |
Cerebral gyrencephaly, distinguished by the convoluted folds and grooves in the cerebral cortex, occurs in many animals in Class Mammalia. The highest rates of cerebral gyrification occur in Order Cetacea within the Superorder Cetartiodactyla. Of all cetaceans, two members of Family Delphinidae, Orcinus orca (killer whales) and Tursiops truncatus (Atlantic bottlenose dolphins) have exceptionally high indices of cerebral gyrification. Research has shown that mutation in two genes, PAFAH1B1 and NDEL1, both located on human chromosome 17, disrupt gyrencephaly normally observed in human brains. Based on this research, PAFAH1B1 and NDEL1 were evaluated for positive selection in Orcinus orca and Tursiops truncatus, to test the hypothesis that these genes are undergoing adaptive evolution against the background of purifying selection. The results of multiple selection tests supported a set of null hypotheses, indicating that these genes were under purifying, not positive, selection, which supports the hypothesis that delphinid cerebral gyrification is not under the control of either PAFAH1B1 or NDEL1. |
format |
Other/Unknown Material |
author |
Haas, David |
author_facet |
Haas, David |
author_sort |
Haas, David |
title |
PAFAH1B1 and NDEL1 in the Cetartiodactyla superorder: Investigating adaptive evolution in two cerebral gyrification genes in Orcinus orca and Tursiops truncatus |
title_short |
PAFAH1B1 and NDEL1 in the Cetartiodactyla superorder: Investigating adaptive evolution in two cerebral gyrification genes in Orcinus orca and Tursiops truncatus |
title_full |
PAFAH1B1 and NDEL1 in the Cetartiodactyla superorder: Investigating adaptive evolution in two cerebral gyrification genes in Orcinus orca and Tursiops truncatus |
title_fullStr |
PAFAH1B1 and NDEL1 in the Cetartiodactyla superorder: Investigating adaptive evolution in two cerebral gyrification genes in Orcinus orca and Tursiops truncatus |
title_full_unstemmed |
PAFAH1B1 and NDEL1 in the Cetartiodactyla superorder: Investigating adaptive evolution in two cerebral gyrification genes in Orcinus orca and Tursiops truncatus |
title_sort |
pafah1b1 and ndel1 in the cetartiodactyla superorder: investigating adaptive evolution in two cerebral gyrification genes in orcinus orca and tursiops truncatus |
publisher |
Friday Harbor Laboratories |
publishDate |
2013 |
url |
http://hdl.handle.net/1773/27182 |
genre |
Orca Orcinus orca |
genre_facet |
Orca Orcinus orca |
op_relation |
Marine Genomics Research Apprenticeship;Spring, 2013 http://hdl.handle.net/1773/27182 |
_version_ |
1766160952566218752 |