Omega-6 fatty acid biomarkers and incident type 2 diabetes : Pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies
Background: The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with inc...
Published in: | The Lancet Diabetes & Endocrinology |
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ftunivwagenin:oai:library.wur.nl:wurpubs/528853 2024-04-28T08:26:19+00:00 Omega-6 fatty acid biomarkers and incident type 2 diabetes : Pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies Wu, Jason H.Y. Marklund, Matti Imamura, Fumiaki Tintle, Nathan Ardisson Korat, Andres V. de Goede, Janette Zhou, Xia Yang, Wei Sin de Oliveira Otto, Marcia C. Kröger, Janine Qureshi, Waqas Virtanen, Jyrki K. Bassett, Julie K. Frazier-Wood, Alexis C. Lankinen, Maria Murphy, Rachel A. Rajaobelina, Kalina Del Gobbo, Liana C. Forouhi, Nita G. Luben, Robert Khaw, Kay Tee Wareham, Nick Kalsbeek, Anya Veenstra, Jenna Luo, Juhua Hu, Frank B. Lin, Hung Ju Siscovick, David S. Boeing, Heiner Chen, Tzu An Steffen, Brian Steffen, Lyn M. Hodge, Allison Eriksdottir, Gudny Smith, Albert V. Gudnason, Vilmunder Harris, Tamara B. Brouwer, Ingeborg A. Berr, Claudine Helmer, Catherine Samieri, Cecilia Laakso, Markku Tsai, Michael Y. Giles, Graham G. Nurmi, Tarja Wagenknecht, Lynne Schulze, Matthias B. Lemaitre, Rozenn N. Chien, Kuo Liong Soedamah-Muthu, Sabita S. Geleijnse, Johanna M. Sun, Qi Harris, William S. Lind, Lars Ärnlöv, Johan Riserus, Ulf Micha, Renata Mozaffarian, Dariush 2017 text/html https://research.wur.nl/en/publications/omega-6-fatty-acid-biomarkers-and-incident-type-2-diabetes-pooled https://doi.org/10.1016/S2213-8587(17)30307-8 en eng https://edepot.wur.nl/426114 https://research.wur.nl/en/publications/omega-6-fatty-acid-biomarkers-and-incident-type-2-diabetes-pooled doi:10.1016/S2213-8587(17)30307-8 Wageningen University & Research The Lancet Diabetes & Endocrinology 5 (2017) 12 ISSN: 2213-8587 Life Science Article/Letter to editor 2017 ftunivwagenin https://doi.org/10.1016/S2213-8587(17)30307-8 2024-04-03T15:23:10Z Background: The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes. Methods: We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes. We analysed data from 20 prospective cohort studies from ten countries (Iceland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), with biomarkers sampled between 1970 and 2010. Participants included in the analyses were aged 18 years or older and had data available for linoleic acid and arachidonic acid biomarkers at baseline. We excluded participants with type 2 diabetes at baseline. The main outcome was the association between omega-6 PUFA biomarkers and incident type 2 diabetes. We assessed the relative risk of type 2 diabetes prospectively for each cohort and lipid compartment separately using a prespecified analytic plan for exposures, covariates, effect modifiers, and analysis, and the findings were then pooled using inverse-variance weighted meta-analysis. Findings: Participants were 39 740 adults, aged (range of cohort means) 49-76 years with a BMI (range of cohort means) of 23·3-28·4 kg/m2, who did not have type 2 diabetes at baseline. During a follow-up of 366 073 person-years, we identified 4347 cases of incident type 2 diabetes. In multivariable-adjusted pooled analyses, higher proportions of linoleic acid biomarkers as percentages of total fatty acid were associated with a lower risk of type 2 diabetes overall (risk ratio [RR] per interquintile range 0·65, 95% CI 0·60-0·72, p<0·0001; I 2=53·9%, pheterogeneity=0·002). The associations between linoleic acid biomarkers and type 2 diabetes were generally similar in different lipid compartments, including ... Article in Journal/Newspaper Iceland Wageningen UR (University & Research Centre): Digital Library The Lancet Diabetes & Endocrinology 5 12 965 974 |
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Wageningen UR (University & Research Centre): Digital Library |
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ftunivwagenin |
language |
English |
topic |
Life Science |
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Life Science Wu, Jason H.Y. Marklund, Matti Imamura, Fumiaki Tintle, Nathan Ardisson Korat, Andres V. de Goede, Janette Zhou, Xia Yang, Wei Sin de Oliveira Otto, Marcia C. Kröger, Janine Qureshi, Waqas Virtanen, Jyrki K. Bassett, Julie K. Frazier-Wood, Alexis C. Lankinen, Maria Murphy, Rachel A. Rajaobelina, Kalina Del Gobbo, Liana C. Forouhi, Nita G. Luben, Robert Khaw, Kay Tee Wareham, Nick Kalsbeek, Anya Veenstra, Jenna Luo, Juhua Hu, Frank B. Lin, Hung Ju Siscovick, David S. Boeing, Heiner Chen, Tzu An Steffen, Brian Steffen, Lyn M. Hodge, Allison Eriksdottir, Gudny Smith, Albert V. Gudnason, Vilmunder Harris, Tamara B. Brouwer, Ingeborg A. Berr, Claudine Helmer, Catherine Samieri, Cecilia Laakso, Markku Tsai, Michael Y. Giles, Graham G. Nurmi, Tarja Wagenknecht, Lynne Schulze, Matthias B. Lemaitre, Rozenn N. Chien, Kuo Liong Soedamah-Muthu, Sabita S. Geleijnse, Johanna M. Sun, Qi Harris, William S. Lind, Lars Ärnlöv, Johan Riserus, Ulf Micha, Renata Mozaffarian, Dariush Omega-6 fatty acid biomarkers and incident type 2 diabetes : Pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies |
topic_facet |
Life Science |
description |
Background: The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes. Methods: We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes. We analysed data from 20 prospective cohort studies from ten countries (Iceland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), with biomarkers sampled between 1970 and 2010. Participants included in the analyses were aged 18 years or older and had data available for linoleic acid and arachidonic acid biomarkers at baseline. We excluded participants with type 2 diabetes at baseline. The main outcome was the association between omega-6 PUFA biomarkers and incident type 2 diabetes. We assessed the relative risk of type 2 diabetes prospectively for each cohort and lipid compartment separately using a prespecified analytic plan for exposures, covariates, effect modifiers, and analysis, and the findings were then pooled using inverse-variance weighted meta-analysis. Findings: Participants were 39 740 adults, aged (range of cohort means) 49-76 years with a BMI (range of cohort means) of 23·3-28·4 kg/m2, who did not have type 2 diabetes at baseline. During a follow-up of 366 073 person-years, we identified 4347 cases of incident type 2 diabetes. In multivariable-adjusted pooled analyses, higher proportions of linoleic acid biomarkers as percentages of total fatty acid were associated with a lower risk of type 2 diabetes overall (risk ratio [RR] per interquintile range 0·65, 95% CI 0·60-0·72, p<0·0001; I 2=53·9%, pheterogeneity=0·002). The associations between linoleic acid biomarkers and type 2 diabetes were generally similar in different lipid compartments, including ... |
format |
Article in Journal/Newspaper |
author |
Wu, Jason H.Y. Marklund, Matti Imamura, Fumiaki Tintle, Nathan Ardisson Korat, Andres V. de Goede, Janette Zhou, Xia Yang, Wei Sin de Oliveira Otto, Marcia C. Kröger, Janine Qureshi, Waqas Virtanen, Jyrki K. Bassett, Julie K. Frazier-Wood, Alexis C. Lankinen, Maria Murphy, Rachel A. Rajaobelina, Kalina Del Gobbo, Liana C. Forouhi, Nita G. Luben, Robert Khaw, Kay Tee Wareham, Nick Kalsbeek, Anya Veenstra, Jenna Luo, Juhua Hu, Frank B. Lin, Hung Ju Siscovick, David S. Boeing, Heiner Chen, Tzu An Steffen, Brian Steffen, Lyn M. Hodge, Allison Eriksdottir, Gudny Smith, Albert V. Gudnason, Vilmunder Harris, Tamara B. Brouwer, Ingeborg A. Berr, Claudine Helmer, Catherine Samieri, Cecilia Laakso, Markku Tsai, Michael Y. Giles, Graham G. Nurmi, Tarja Wagenknecht, Lynne Schulze, Matthias B. Lemaitre, Rozenn N. Chien, Kuo Liong Soedamah-Muthu, Sabita S. Geleijnse, Johanna M. Sun, Qi Harris, William S. Lind, Lars Ärnlöv, Johan Riserus, Ulf Micha, Renata Mozaffarian, Dariush |
author_facet |
Wu, Jason H.Y. Marklund, Matti Imamura, Fumiaki Tintle, Nathan Ardisson Korat, Andres V. de Goede, Janette Zhou, Xia Yang, Wei Sin de Oliveira Otto, Marcia C. Kröger, Janine Qureshi, Waqas Virtanen, Jyrki K. Bassett, Julie K. Frazier-Wood, Alexis C. Lankinen, Maria Murphy, Rachel A. Rajaobelina, Kalina Del Gobbo, Liana C. Forouhi, Nita G. Luben, Robert Khaw, Kay Tee Wareham, Nick Kalsbeek, Anya Veenstra, Jenna Luo, Juhua Hu, Frank B. Lin, Hung Ju Siscovick, David S. Boeing, Heiner Chen, Tzu An Steffen, Brian Steffen, Lyn M. Hodge, Allison Eriksdottir, Gudny Smith, Albert V. Gudnason, Vilmunder Harris, Tamara B. Brouwer, Ingeborg A. Berr, Claudine Helmer, Catherine Samieri, Cecilia Laakso, Markku Tsai, Michael Y. Giles, Graham G. Nurmi, Tarja Wagenknecht, Lynne Schulze, Matthias B. Lemaitre, Rozenn N. Chien, Kuo Liong Soedamah-Muthu, Sabita S. Geleijnse, Johanna M. Sun, Qi Harris, William S. Lind, Lars Ärnlöv, Johan Riserus, Ulf Micha, Renata Mozaffarian, Dariush |
author_sort |
Wu, Jason H.Y. |
title |
Omega-6 fatty acid biomarkers and incident type 2 diabetes : Pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies |
title_short |
Omega-6 fatty acid biomarkers and incident type 2 diabetes : Pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies |
title_full |
Omega-6 fatty acid biomarkers and incident type 2 diabetes : Pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies |
title_fullStr |
Omega-6 fatty acid biomarkers and incident type 2 diabetes : Pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies |
title_full_unstemmed |
Omega-6 fatty acid biomarkers and incident type 2 diabetes : Pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies |
title_sort |
omega-6 fatty acid biomarkers and incident type 2 diabetes : pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies |
publishDate |
2017 |
url |
https://research.wur.nl/en/publications/omega-6-fatty-acid-biomarkers-and-incident-type-2-diabetes-pooled https://doi.org/10.1016/S2213-8587(17)30307-8 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
The Lancet Diabetes & Endocrinology 5 (2017) 12 ISSN: 2213-8587 |
op_relation |
https://edepot.wur.nl/426114 https://research.wur.nl/en/publications/omega-6-fatty-acid-biomarkers-and-incident-type-2-diabetes-pooled doi:10.1016/S2213-8587(17)30307-8 |
op_rights |
Wageningen University & Research |
op_doi |
https://doi.org/10.1016/S2213-8587(17)30307-8 |
container_title |
The Lancet Diabetes & Endocrinology |
container_volume |
5 |
container_issue |
12 |
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965 |
op_container_end_page |
974 |
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