Effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (Larus argentatus) chicks
The aim of the present study was to investigate how contaminant exposure and reduced food intake affect tissue distribution and biotransformation of halogenated organic contaminants (HOCs) in Arctic seabirds using herring gull (Larus argentatus) as a model species. Herring gull chicks were exposed f...
Published in: | Environmental Toxicology and Chemistry |
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Language: | English |
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ftunivwagenin:oai:library.wur.nl:wurpubs/456038 2024-02-04T09:57:45+01:00 Effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (Larus argentatus) chicks Routti, H. Helgason, L.B. Arukwe, A. Wolkers, J. Heimstad, E.S. Harju, M. Berg, V. Gabrielsen, G.W. 2013 application/pdf https://research.wur.nl/en/publications/effect-of-reduced-food-intake-on-toxicokinetics-of-halogenated-or https://doi.org/10.1002/etc.2026 en eng https://edepot.wur.nl/311568 https://research.wur.nl/en/publications/effect-of-reduced-food-intake-on-toxicokinetics-of-halogenated-or doi:10.1002/etc.2026 info:eu-repo/semantics/restrictedAccess Wageningen University & Research Environmental Toxicology and Chemistry 32 (2013) 1 ISSN: 0730-7268 arctic seabirds bioaccumulation biotransformation blood metabolites o-dealkylation organochlorine contaminants pcbs polychlorinated-biphenyls rat-liver info:eu-repo/semantics/article Article/Letter to editor info:eu-repo/semantics/publishedVersion 2013 ftunivwagenin https://doi.org/10.1002/etc.2026 2024-01-10T23:20:32Z The aim of the present study was to investigate how contaminant exposure and reduced food intake affect tissue distribution and biotransformation of halogenated organic contaminants (HOCs) in Arctic seabirds using herring gull (Larus argentatus) as a model species. Herring gull chicks were exposed for 44 d to cod liver oil containing a typical mixture of contaminants. Following exposure, food intake was reduced for a one-week period in a subgroup of the chicks. Polyclorinated biphenyls, organochlorine pesticides, and brominated flame retardants, as well as a wide range of hydroxy, methyl sulfone, and methoxy compounds were measured in liver, brain, and plasma samples. Additionally, phase I biotransformation enzyme activities and phase I and II messenger ribonucleic acid (mRNA) expression were investigated in the liver, brain, or both. Both contaminant exposure and reduced food intake had an increasing effect on the concentrations of HOCs and their metabolites. The HOC exposure and reduced food intake also led to increased 7-ethoxyresorufin-O-deethylation (EROD) activity, whereas mRNA expression of the biotransformation enzymes increased only following the reduced food intake. Tissue distribution of HOCs and their metabolites was not affected by either contaminant exposure or reduced food intake. In conclusion, the results indicate that biotransformation capacity and formation of HOC metabolites increase during reduced food intake. This finding supports the hypothesis that reduced food intake increases the susceptibility of Arctic animals to the effects of lipophilic HOCs. Environ. Toxicol. Chem. 2013;32:156164. (c) 2012 SETAC Article in Journal/Newspaper Arctic Wageningen UR (University & Research Centre): Digital Library Arctic Environmental Toxicology and Chemistry 32 1 156 164 |
institution |
Open Polar |
collection |
Wageningen UR (University & Research Centre): Digital Library |
op_collection_id |
ftunivwagenin |
language |
English |
topic |
arctic seabirds bioaccumulation biotransformation blood metabolites o-dealkylation organochlorine contaminants pcbs polychlorinated-biphenyls rat-liver |
spellingShingle |
arctic seabirds bioaccumulation biotransformation blood metabolites o-dealkylation organochlorine contaminants pcbs polychlorinated-biphenyls rat-liver Routti, H. Helgason, L.B. Arukwe, A. Wolkers, J. Heimstad, E.S. Harju, M. Berg, V. Gabrielsen, G.W. Effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (Larus argentatus) chicks |
topic_facet |
arctic seabirds bioaccumulation biotransformation blood metabolites o-dealkylation organochlorine contaminants pcbs polychlorinated-biphenyls rat-liver |
description |
The aim of the present study was to investigate how contaminant exposure and reduced food intake affect tissue distribution and biotransformation of halogenated organic contaminants (HOCs) in Arctic seabirds using herring gull (Larus argentatus) as a model species. Herring gull chicks were exposed for 44 d to cod liver oil containing a typical mixture of contaminants. Following exposure, food intake was reduced for a one-week period in a subgroup of the chicks. Polyclorinated biphenyls, organochlorine pesticides, and brominated flame retardants, as well as a wide range of hydroxy, methyl sulfone, and methoxy compounds were measured in liver, brain, and plasma samples. Additionally, phase I biotransformation enzyme activities and phase I and II messenger ribonucleic acid (mRNA) expression were investigated in the liver, brain, or both. Both contaminant exposure and reduced food intake had an increasing effect on the concentrations of HOCs and their metabolites. The HOC exposure and reduced food intake also led to increased 7-ethoxyresorufin-O-deethylation (EROD) activity, whereas mRNA expression of the biotransformation enzymes increased only following the reduced food intake. Tissue distribution of HOCs and their metabolites was not affected by either contaminant exposure or reduced food intake. In conclusion, the results indicate that biotransformation capacity and formation of HOC metabolites increase during reduced food intake. This finding supports the hypothesis that reduced food intake increases the susceptibility of Arctic animals to the effects of lipophilic HOCs. Environ. Toxicol. Chem. 2013;32:156164. (c) 2012 SETAC |
format |
Article in Journal/Newspaper |
author |
Routti, H. Helgason, L.B. Arukwe, A. Wolkers, J. Heimstad, E.S. Harju, M. Berg, V. Gabrielsen, G.W. |
author_facet |
Routti, H. Helgason, L.B. Arukwe, A. Wolkers, J. Heimstad, E.S. Harju, M. Berg, V. Gabrielsen, G.W. |
author_sort |
Routti, H. |
title |
Effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (Larus argentatus) chicks |
title_short |
Effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (Larus argentatus) chicks |
title_full |
Effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (Larus argentatus) chicks |
title_fullStr |
Effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (Larus argentatus) chicks |
title_full_unstemmed |
Effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (Larus argentatus) chicks |
title_sort |
effect of reduced food intake on toxicokinetics of halogenated organic contaminants in herring gull (larus argentatus) chicks |
publishDate |
2013 |
url |
https://research.wur.nl/en/publications/effect-of-reduced-food-intake-on-toxicokinetics-of-halogenated-or https://doi.org/10.1002/etc.2026 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Environmental Toxicology and Chemistry 32 (2013) 1 ISSN: 0730-7268 |
op_relation |
https://edepot.wur.nl/311568 https://research.wur.nl/en/publications/effect-of-reduced-food-intake-on-toxicokinetics-of-halogenated-or doi:10.1002/etc.2026 |
op_rights |
info:eu-repo/semantics/restrictedAccess Wageningen University & Research |
op_doi |
https://doi.org/10.1002/etc.2026 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
32 |
container_issue |
1 |
container_start_page |
156 |
op_container_end_page |
164 |
_version_ |
1789962066638929920 |