Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives
A methodology has been developed for an efficient and selective lipase-catalyzed aza-Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was found that Pseudomonas stutzeri lipas...
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ftunivwagenin:oai:library.wur.nl:wurpubs/439764 2024-02-04T09:55:19+01:00 Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives Steunenberg, P. Sijm, M. Zuilhof, H. Sanders, J.P.M. Scott, E.L. Franssen, M.C.R. 2013 application/pdf https://research.wur.nl/en/publications/lipase-catalyzed-aza-michael-reaction-on-acrylate-derivatives https://doi.org/10.1021/jo400268u en eng https://edepot.wur.nl/259944 https://research.wur.nl/en/publications/lipase-catalyzed-aza-michael-reaction-on-acrylate-derivatives doi:10.1021/jo400268u info:eu-repo/semantics/restrictedAccess Wageningen University & Research Journal of Organic Chemistry 78 (2013) 8 ISSN: 0022-3263 acrylonitrile additions aminolysis reactions biocatalysis candida-antarctica chemoselectivity enzyme immobilization monomers organic-solvents secondary-amines info:eu-repo/semantics/article Article/Letter to editor info:eu-repo/semantics/publishedVersion 2013 ftunivwagenin https://doi.org/10.1021/jo400268u 2024-01-10T23:20:38Z A methodology has been developed for an efficient and selective lipase-catalyzed aza-Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was found that Pseudomonas stutzeri lipase and Chromobacterium viscosum lipase showed the highest selectivity for the aza-Michael addition to substituted alkyl acrylates. For the first time also, some CLEAs were examined that showed a comparable or higher selectivity and yield than the free enzymes and other formulations. Article in Journal/Newspaper Antarc* Antarctica Wageningen UR (University & Research Centre): Digital Library The Journal of Organic Chemistry 78 8 3802 3813 |
institution |
Open Polar |
collection |
Wageningen UR (University & Research Centre): Digital Library |
op_collection_id |
ftunivwagenin |
language |
English |
topic |
acrylonitrile additions aminolysis reactions biocatalysis candida-antarctica chemoselectivity enzyme immobilization monomers organic-solvents secondary-amines |
spellingShingle |
acrylonitrile additions aminolysis reactions biocatalysis candida-antarctica chemoselectivity enzyme immobilization monomers organic-solvents secondary-amines Steunenberg, P. Sijm, M. Zuilhof, H. Sanders, J.P.M. Scott, E.L. Franssen, M.C.R. Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives |
topic_facet |
acrylonitrile additions aminolysis reactions biocatalysis candida-antarctica chemoselectivity enzyme immobilization monomers organic-solvents secondary-amines |
description |
A methodology has been developed for an efficient and selective lipase-catalyzed aza-Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was found that Pseudomonas stutzeri lipase and Chromobacterium viscosum lipase showed the highest selectivity for the aza-Michael addition to substituted alkyl acrylates. For the first time also, some CLEAs were examined that showed a comparable or higher selectivity and yield than the free enzymes and other formulations. |
format |
Article in Journal/Newspaper |
author |
Steunenberg, P. Sijm, M. Zuilhof, H. Sanders, J.P.M. Scott, E.L. Franssen, M.C.R. |
author_facet |
Steunenberg, P. Sijm, M. Zuilhof, H. Sanders, J.P.M. Scott, E.L. Franssen, M.C.R. |
author_sort |
Steunenberg, P. |
title |
Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives |
title_short |
Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives |
title_full |
Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives |
title_fullStr |
Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives |
title_full_unstemmed |
Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives |
title_sort |
lipase-catalyzed aza-michael reaction on acrylate derivatives |
publishDate |
2013 |
url |
https://research.wur.nl/en/publications/lipase-catalyzed-aza-michael-reaction-on-acrylate-derivatives https://doi.org/10.1021/jo400268u |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Journal of Organic Chemistry 78 (2013) 8 ISSN: 0022-3263 |
op_relation |
https://edepot.wur.nl/259944 https://research.wur.nl/en/publications/lipase-catalyzed-aza-michael-reaction-on-acrylate-derivatives doi:10.1021/jo400268u |
op_rights |
info:eu-repo/semantics/restrictedAccess Wageningen University & Research |
op_doi |
https://doi.org/10.1021/jo400268u |
container_title |
The Journal of Organic Chemistry |
container_volume |
78 |
container_issue |
8 |
container_start_page |
3802 |
op_container_end_page |
3813 |
_version_ |
1789959242024747008 |