Low Temperature-Dependent Salmonid Alphavirus Glycoprotein Processing and Recombinant Virus-Like Particle Formation

• Published in: PLoS ONE
• Main Authors: Metz, S.W.H., Feenstra, F., Villoing, S., van Hulten, M.C., van Lent, J.W.M., Koumans, J., Vlak, J.M., Pijlman, G.P.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2011
• Subjects: atlantic salmon; baculovirus vectors; equine encephalitis-virus; nuclear polyhedrosis-virus; nucleocapsid protein; pancreas disease; semliki-forest-virus; sleeping-disease; spodoptera-frugiperda; swine-fever virus; Sav’; Atlantic salmon
• Online Access: https://research.wur.nl/en/publications/low-temperature-dependent-salmonid-alphavirus-glycoprotein-proces; https://doi.org/10.1371/journal.pone.0025816

Pancreas disease (PD) and sleeping disease (SD) are important viral scourges in aquaculture of Atlantic salmon and rainbow trout. The etiological agent of PD and SD is salmonid alphavirus (SAV), an unusual member of the Togaviridae (genus Alphavirus). SAV replicates at lower temperatures in fish. Ou...