Not All Bones are Created Equal - Using Zebrafish and Other Teleost Species in Osteogenesis Research

• Main Authors: Apschner, A., Schulte-Merker, S., Witten, P.E.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2011
• Subjects: acellular bone; astatotilapia-elegans teleostei; atlantic salmon; chondroid bone; danio-rerio; oreochromis-niloticus; oryzias-latipes teleostei; salmon salmo-salar; skeletal development; upper pharyngeal jaws; Atlantic salmon; Salmo salar
• Online Access: https://research.wur.nl/en/publications/not-all-bones-are-created-equal-using-zebrafish-and-other-teleost; https://doi.org/10.1016/B978-0-12-381320-6.00010-2

Developmental osteogenesis and pathologies of mineralized tissues are areas of intense investigations in the mammalian field, but different from other areas of organ formation and developmental biology, zebrafish have been somewhat slow in joining the area of bone research. In recent years, however, genetic screens have provided a number of exciting mutants, and transgenic lines have been developed that permit visualization of osteoblasts and osteoclasts in vivo. We here review some of the recent literature and provide examples where insights from studies in zebrafish have complemented the information available from mammalian models or clinical studies. Furthermore, we provide a comparative overview about different forms of bone within the teleost lineage, and between teleosts and mammals