Impact of antibacterial drugs on the health of European eel
Application of antibacterial drugs plays an important role in the control of bacterial diseases in intensive fish culture. However, since the scientific basis for the use of these drugs is yet inadequate, there is a growing concern about the safety of fish medication for the consumer, the environmen...
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Landbouwuniversiteit Wageningen
1996
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ftunivwagenin:oai:library.wur.nl:wurpubs/33423 2024-02-04T09:52:58+01:00 Impact of antibacterial drugs on the health of European eel van der Heijden, M.H.T. 1996 application/pdf https://research.wur.nl/en/publications/impact-of-antibacterial-drugs-on-the-health-of-european-eel en eng Landbouwuniversiteit Wageningen https://edepot.wur.nl/206530 https://research.wur.nl/en/publications/impact-of-antibacterial-drugs-on-the-health-of-european-eel info:eu-repo/semantics/openAccess Wageningen University & Research adverse effects animal products antibiotics drugs eels food contamination game animals hormones veterinary products veterinary science vitamins antibiotica diergeneeskunde dierlijke producten geneesmiddelen hormonen jachtdieren nadelige gevolgen palingen veterinaire producten vitaminen voedselbesmetting info:eu-repo/semantics/doctoralThesis Doctoral thesis info:eu-repo/semantics/publishedVersion 1996 ftunivwagenin 2024-01-10T23:29:25Z Application of antibacterial drugs plays an important role in the control of bacterial diseases in intensive fish culture. However, since the scientific basis for the use of these drugs is yet inadequate, there is a growing concern about the safety of fish medication for the consumer, the environment and the target animals. This led to the research presented in this thesis, which is focused on the influence of the antibacterial drug flumequine on the defence system of European eel (Anguilla anguilla L., 1758). Eel appeared to be an interesting model because the initial, pharmacokinetic investigations demonstrated that flumequine is very slowly eliminated from both plasma and tissues in this species. Treatment of eels with flumequine resulted in an enhanced proliferation of (probably surface immunoglobulin negative) lymphoid cells as assessed by means of an in vivo lymphocyte stimulation assay and monoclonal antibodies to eel immunoglobulin, respectively. The effect of the drug on the integral functioning of the defence system was subsequently examined by using a ,challenge with the parasitic nematode Anguillicola crassus. The resulting parasite recoveries pointed to an improved protection in flumequine-treated eels, which seemed to be related to a modulation of the cellular response. Doctoral or Postdoctoral Thesis Anguilla anguilla European eel Wageningen UR (University & Research Centre): Digital Library |
institution |
Open Polar |
collection |
Wageningen UR (University & Research Centre): Digital Library |
op_collection_id |
ftunivwagenin |
language |
English |
topic |
adverse effects animal products antibiotics drugs eels food contamination game animals hormones veterinary products veterinary science vitamins antibiotica diergeneeskunde dierlijke producten geneesmiddelen hormonen jachtdieren nadelige gevolgen palingen veterinaire producten vitaminen voedselbesmetting |
spellingShingle |
adverse effects animal products antibiotics drugs eels food contamination game animals hormones veterinary products veterinary science vitamins antibiotica diergeneeskunde dierlijke producten geneesmiddelen hormonen jachtdieren nadelige gevolgen palingen veterinaire producten vitaminen voedselbesmetting van der Heijden, M.H.T. Impact of antibacterial drugs on the health of European eel |
topic_facet |
adverse effects animal products antibiotics drugs eels food contamination game animals hormones veterinary products veterinary science vitamins antibiotica diergeneeskunde dierlijke producten geneesmiddelen hormonen jachtdieren nadelige gevolgen palingen veterinaire producten vitaminen voedselbesmetting |
description |
Application of antibacterial drugs plays an important role in the control of bacterial diseases in intensive fish culture. However, since the scientific basis for the use of these drugs is yet inadequate, there is a growing concern about the safety of fish medication for the consumer, the environment and the target animals. This led to the research presented in this thesis, which is focused on the influence of the antibacterial drug flumequine on the defence system of European eel (Anguilla anguilla L., 1758). Eel appeared to be an interesting model because the initial, pharmacokinetic investigations demonstrated that flumequine is very slowly eliminated from both plasma and tissues in this species. Treatment of eels with flumequine resulted in an enhanced proliferation of (probably surface immunoglobulin negative) lymphoid cells as assessed by means of an in vivo lymphocyte stimulation assay and monoclonal antibodies to eel immunoglobulin, respectively. The effect of the drug on the integral functioning of the defence system was subsequently examined by using a ,challenge with the parasitic nematode Anguillicola crassus. The resulting parasite recoveries pointed to an improved protection in flumequine-treated eels, which seemed to be related to a modulation of the cellular response. |
format |
Doctoral or Postdoctoral Thesis |
author |
van der Heijden, M.H.T. |
author_facet |
van der Heijden, M.H.T. |
author_sort |
van der Heijden, M.H.T. |
title |
Impact of antibacterial drugs on the health of European eel |
title_short |
Impact of antibacterial drugs on the health of European eel |
title_full |
Impact of antibacterial drugs on the health of European eel |
title_fullStr |
Impact of antibacterial drugs on the health of European eel |
title_full_unstemmed |
Impact of antibacterial drugs on the health of European eel |
title_sort |
impact of antibacterial drugs on the health of european eel |
publisher |
Landbouwuniversiteit Wageningen |
publishDate |
1996 |
url |
https://research.wur.nl/en/publications/impact-of-antibacterial-drugs-on-the-health-of-european-eel |
genre |
Anguilla anguilla European eel |
genre_facet |
Anguilla anguilla European eel |
op_relation |
https://edepot.wur.nl/206530 https://research.wur.nl/en/publications/impact-of-antibacterial-drugs-on-the-health-of-european-eel |
op_rights |
info:eu-repo/semantics/openAccess Wageningen University & Research |
_version_ |
1789963096336367616 |