Unique haplotypes of co-segregating major histocompatibility class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes
Sequence-based typing of a breeding population (G1) consisting of 84 Atlantic salmon individuals revealed the presence of 7 Sasa-DAA and 7 Sasa-DAB expressed alleles. Subsequent typing of 1,182 individuals belonging to 33 families showed that Sasa-DAA and Sasa-DAB segregate as haplotypes. In total s...
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ftunivwagenin:oai:library.wur.nl:wurpubs/123099 2024-02-04T09:58:53+01:00 Unique haplotypes of co-segregating major histocompatibility class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes Stet, R.J.M. de Vries, B.J. Mudde, C.M. Hermsen, G.J. van Heerwaarden, J. Shum, B.P. Grimholt, U. 2002 application/pdf https://research.wur.nl/en/publications/unique-haplotypes-of-co-segregating-major-histocompatibility-clas https://doi.org/10.1007/s00251-002-0477-1 en eng https://edepot.wur.nl/147331 https://research.wur.nl/en/publications/unique-haplotypes-of-co-segregating-major-histocompatibility-clas doi:10.1007/s00251-002-0477-1 info:eu-repo/semantics/restrictedAccess Wageningen University & Research Immunogenetics 54 (2002) ISSN: 0093-7711 Atlantic salmon Class II Genotyping MHC Segregation info:eu-repo/semantics/article Article/Letter to editor info:eu-repo/semantics/publishedVersion 2002 ftunivwagenin https://doi.org/10.1007/s00251-002-0477-1 2024-01-10T23:27:25Z Sequence-based typing of a breeding population (G1) consisting of 84 Atlantic salmon individuals revealed the presence of 7 Sasa-DAA and 7 Sasa-DAB expressed alleles. Subsequent typing of 1,182 individuals belonging to 33 families showed that Sasa-DAA and Sasa-DAB segregate as haplotypes. In total seven unique haplotypes were established, with frequencies in the population studied ranging from 0.01 to 0.49. Each haplotype is characterized by a unique minisatellite marker size embedded in the 3' untranslated region of the Sasa-DAA gene. These data corroborate the fact that Atlantic salmon express a single class II locus, consisting of tightly linked class II A and class B genes. The seven haplotypes give rise to 15 genotypes with frequencies varying between 0.01 and 0.23; 21 class II homozygous individuals were present in the G1 population. We also studied the frequency distribution in another breeding population (G4, n=374) using the minisatellite marker. Only one new marker size was present, suggesting the presence of one new class II haplotype. The marker frequency distribution in the G4 population differed markedly from the G1 population. The genomic organizations of two Sasa-DAA and Sasa-DAB alleles were determined, and supported the notion that these alleles belong to the same locus. In contrast to other studies of salmonid class II sequences, phylogenetic analyses of brown trout and Atlantic class II A and class II B sequences provided support for trans-species polymorphism Article in Journal/Newspaper Atlantic salmon Salmo salar Wageningen UR (University & Research Centre): Digital Library PLOS ONE 12 7 e0179907 |
institution |
Open Polar |
collection |
Wageningen UR (University & Research Centre): Digital Library |
op_collection_id |
ftunivwagenin |
language |
English |
topic |
Atlantic salmon Class II Genotyping MHC Segregation |
spellingShingle |
Atlantic salmon Class II Genotyping MHC Segregation Stet, R.J.M. de Vries, B.J. Mudde, C.M. Hermsen, G.J. van Heerwaarden, J. Shum, B.P. Grimholt, U. Unique haplotypes of co-segregating major histocompatibility class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes |
topic_facet |
Atlantic salmon Class II Genotyping MHC Segregation |
description |
Sequence-based typing of a breeding population (G1) consisting of 84 Atlantic salmon individuals revealed the presence of 7 Sasa-DAA and 7 Sasa-DAB expressed alleles. Subsequent typing of 1,182 individuals belonging to 33 families showed that Sasa-DAA and Sasa-DAB segregate as haplotypes. In total seven unique haplotypes were established, with frequencies in the population studied ranging from 0.01 to 0.49. Each haplotype is characterized by a unique minisatellite marker size embedded in the 3' untranslated region of the Sasa-DAA gene. These data corroborate the fact that Atlantic salmon express a single class II locus, consisting of tightly linked class II A and class B genes. The seven haplotypes give rise to 15 genotypes with frequencies varying between 0.01 and 0.23; 21 class II homozygous individuals were present in the G1 population. We also studied the frequency distribution in another breeding population (G4, n=374) using the minisatellite marker. Only one new marker size was present, suggesting the presence of one new class II haplotype. The marker frequency distribution in the G4 population differed markedly from the G1 population. The genomic organizations of two Sasa-DAA and Sasa-DAB alleles were determined, and supported the notion that these alleles belong to the same locus. In contrast to other studies of salmonid class II sequences, phylogenetic analyses of brown trout and Atlantic class II A and class II B sequences provided support for trans-species polymorphism |
format |
Article in Journal/Newspaper |
author |
Stet, R.J.M. de Vries, B.J. Mudde, C.M. Hermsen, G.J. van Heerwaarden, J. Shum, B.P. Grimholt, U. |
author_facet |
Stet, R.J.M. de Vries, B.J. Mudde, C.M. Hermsen, G.J. van Heerwaarden, J. Shum, B.P. Grimholt, U. |
author_sort |
Stet, R.J.M. |
title |
Unique haplotypes of co-segregating major histocompatibility class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes |
title_short |
Unique haplotypes of co-segregating major histocompatibility class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes |
title_full |
Unique haplotypes of co-segregating major histocompatibility class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes |
title_fullStr |
Unique haplotypes of co-segregating major histocompatibility class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes |
title_full_unstemmed |
Unique haplotypes of co-segregating major histocompatibility class II A and class II B alleles in Atlantic salmon (Salmo salar) give rise to diverse class II genotypes |
title_sort |
unique haplotypes of co-segregating major histocompatibility class ii a and class ii b alleles in atlantic salmon (salmo salar) give rise to diverse class ii genotypes |
publishDate |
2002 |
url |
https://research.wur.nl/en/publications/unique-haplotypes-of-co-segregating-major-histocompatibility-clas https://doi.org/10.1007/s00251-002-0477-1 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Immunogenetics 54 (2002) ISSN: 0093-7711 |
op_relation |
https://edepot.wur.nl/147331 https://research.wur.nl/en/publications/unique-haplotypes-of-co-segregating-major-histocompatibility-clas doi:10.1007/s00251-002-0477-1 |
op_rights |
info:eu-repo/semantics/restrictedAccess Wageningen University & Research |
op_doi |
https://doi.org/10.1007/s00251-002-0477-1 |
container_title |
PLOS ONE |
container_volume |
12 |
container_issue |
7 |
container_start_page |
e0179907 |
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1789963461178949632 |