Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS)
Attempts to compare bronchial responsiveness between populations have been hampered by between-study differences in the pharmacological agent of provocation, the method of administration and the summary statistic employed. The European Community Respiratory Health Survey used methacholine challenge...
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ftunivveronairis:oai:iris.univr.it:11562/308014 2024-04-21T08:05:45+00:00 Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS) S. Chinn P. Burney D. Jarvis C. Luczynska LO CASCIO, Vincenzo DE MARCO, Roberto S., Chinn P., Burney D., Jarvi C., Luczynska LO CASCIO, Vincenzo DE MARCO, Roberto 1997 http://hdl.handle.net/11562/308014 eng eng info:eu-repo/semantics/altIdentifier/pmid/9426085 info:eu-repo/semantics/altIdentifier/wos/WOS:000070939000012 volume:10 firstpage:2495 lastpage:2501 numberofpages:7 journal:EUROPEAN RESPIRATORY JOURNAL http://hdl.handle.net/11562/308014 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0031460460 info:eu-repo/semantics/article 1997 ftunivveronairis 2024-03-25T15:51:32Z Attempts to compare bronchial responsiveness between populations have been hampered by between-study differences in the pharmacological agent of provocation, the method of administration and the summary statistic employed. The European Community Respiratory Health Survey used methacholine challenge delivered by Mefar dosimeter according to a standardized protocol used in 35 centres in 16 countries. Data were obtained from 13,161 men and women, aged 20-44 yrs at the start of the study. The dose of methacholine producing a 20% fall in forced expiratory volume in one second (FEV1) (PD20) and the regression coefficient of percentage decline in FEV1 with log dose, were calculated ("slope", after transformation), with and without calibration of nebulizers by weight and adjustment for nonresponse bias. Standardization for baseline lung function and variation in smoking prevalence was applied to slope. Results were robust to whichever summary measure was used, and to the various adjustments. Responsiveness was low in Iceland and Switzerland, and in most centres in Sweden, Italy and Spain, and high in New Zealand, Australia, the USA, Britain, France, Denmark and Germany. Bronchial responsiveness varies considerably in Europe, and high levels are not confined to the English-speaking world. Article in Journal/Newspaper Iceland Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
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Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
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ftunivveronairis |
language |
English |
description |
Attempts to compare bronchial responsiveness between populations have been hampered by between-study differences in the pharmacological agent of provocation, the method of administration and the summary statistic employed. The European Community Respiratory Health Survey used methacholine challenge delivered by Mefar dosimeter according to a standardized protocol used in 35 centres in 16 countries. Data were obtained from 13,161 men and women, aged 20-44 yrs at the start of the study. The dose of methacholine producing a 20% fall in forced expiratory volume in one second (FEV1) (PD20) and the regression coefficient of percentage decline in FEV1 with log dose, were calculated ("slope", after transformation), with and without calibration of nebulizers by weight and adjustment for nonresponse bias. Standardization for baseline lung function and variation in smoking prevalence was applied to slope. Results were robust to whichever summary measure was used, and to the various adjustments. Responsiveness was low in Iceland and Switzerland, and in most centres in Sweden, Italy and Spain, and high in New Zealand, Australia, the USA, Britain, France, Denmark and Germany. Bronchial responsiveness varies considerably in Europe, and high levels are not confined to the English-speaking world. |
author2 |
S., Chinn P., Burney D., Jarvi C., Luczynska LO CASCIO, Vincenzo DE MARCO, Roberto |
format |
Article in Journal/Newspaper |
author |
S. Chinn P. Burney D. Jarvis C. Luczynska LO CASCIO, Vincenzo DE MARCO, Roberto |
spellingShingle |
S. Chinn P. Burney D. Jarvis C. Luczynska LO CASCIO, Vincenzo DE MARCO, Roberto Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS) |
author_facet |
S. Chinn P. Burney D. Jarvis C. Luczynska LO CASCIO, Vincenzo DE MARCO, Roberto |
author_sort |
S. Chinn |
title |
Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS) |
title_short |
Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS) |
title_full |
Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS) |
title_fullStr |
Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS) |
title_full_unstemmed |
Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS) |
title_sort |
variation in bronchial responsiveness in the european community respiratory health survey (ecrhs) |
publishDate |
1997 |
url |
http://hdl.handle.net/11562/308014 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/9426085 info:eu-repo/semantics/altIdentifier/wos/WOS:000070939000012 volume:10 firstpage:2495 lastpage:2501 numberofpages:7 journal:EUROPEAN RESPIRATORY JOURNAL http://hdl.handle.net/11562/308014 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0031460460 |
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1796945146366918656 |