Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology
Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. A lack of patho...
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ftunivutrecht:oai:dspace.library.uu.nl:1874/390335 2024-05-19T07:48:05+00:00 Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology de Boer, Rudolf A De Keulenaer, Gilles Bauersachs, Johann Brutsaert, Dirk Cleland, John G Diez, Javier Du, Xiao-Jun Ford, Paul Heinzel, Frank R Lipson, Kenneth E McDonagh, Theresa Lopez-Andres, Natalia Lunde, Ida G Lyon, Alexander R Pollesello, Piero Prasad, Sanjay K Tocchetti, Carlo G Mayr, Manuel Sluijter, Joost P G Thum, Thomas Tschöpe, Carsten Zannad, Faiez Zimmermann, Wolfram-Hubertus Ruschitzka, Frank Filippatos, Gerasimos Lindsey, Merry L Maack, Christoph Heymans, Stephane Onderzoek Cardiovasculair Reg. Med. Circulatory Health Regenerative Medicine and Stem Cells 2019-03-01 image/pdf https://dspace.library.uu.nl/handle/1874/390335 en eng 1388-9842 https://dspace.library.uu.nl/handle/1874/390335 info:eu-repo/semantics/OpenAccess Biomarkers/blood Cardiac Imaging Techniques/methods Disease Management Europe Extracellular Matrix Proteins/blood Fibrosis/classification Heart Failure/diagnosis Humans Myocardium/metabolism Prognosis Research Societies Medical Translational Medical Research Heart failure Matrix Imaging Fibrosis Biomarkers Fibroblast Cardiology and Cardiovascular Medicine Research Support Non-U.S. Gov't Journal Article Article 2019 ftunivutrecht 2024-04-29T15:15:44Z Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. A lack of pathophysiological insights and uniform definitions has hampered the research in fibrosis and heart failure. The Translational Research Committee of the Heart Failure Association discussed several aspects of fibrosis in their workshop. Early insidious perturbations such as subclinical hypertension or inflammation may trigger first fibrotic events, while more dramatic triggers such as myocardial infarction and myocarditis give rise to full blown scar formation and ongoing fibrosis in diseased hearts. Aging itself is also associated with a cardiac phenotype that includes fibrosis. Fibrosis is an extremely heterogeneous phenomenon, as several stages of the fibrotic process exist, each with different fibrosis subtypes and a different composition of various cells and proteins - resulting in a very complex pathophysiology. As a result, detection of fibrosis, e.g. using current cardiac imaging modalities or plasma biomarkers, will detect only specific subforms of fibrosis, but cannot capture all aspects of the complex fibrotic process. Furthermore, several anti-fibrotic therapies are under investigation, but such therapies generally target aspecific aspects of the fibrotic process and suffer from a lack of precision. This review discusses the mechanisms and the caveats and proposes a roadmap for future research. Article in Journal/Newspaper SCAR Utrecht University Repository |
institution |
Open Polar |
collection |
Utrecht University Repository |
op_collection_id |
ftunivutrecht |
language |
English |
topic |
Biomarkers/blood Cardiac Imaging Techniques/methods Disease Management Europe Extracellular Matrix Proteins/blood Fibrosis/classification Heart Failure/diagnosis Humans Myocardium/metabolism Prognosis Research Societies Medical Translational Medical Research Heart failure Matrix Imaging Fibrosis Biomarkers Fibroblast Cardiology and Cardiovascular Medicine Research Support Non-U.S. Gov't Journal Article |
spellingShingle |
Biomarkers/blood Cardiac Imaging Techniques/methods Disease Management Europe Extracellular Matrix Proteins/blood Fibrosis/classification Heart Failure/diagnosis Humans Myocardium/metabolism Prognosis Research Societies Medical Translational Medical Research Heart failure Matrix Imaging Fibrosis Biomarkers Fibroblast Cardiology and Cardiovascular Medicine Research Support Non-U.S. Gov't Journal Article de Boer, Rudolf A De Keulenaer, Gilles Bauersachs, Johann Brutsaert, Dirk Cleland, John G Diez, Javier Du, Xiao-Jun Ford, Paul Heinzel, Frank R Lipson, Kenneth E McDonagh, Theresa Lopez-Andres, Natalia Lunde, Ida G Lyon, Alexander R Pollesello, Piero Prasad, Sanjay K Tocchetti, Carlo G Mayr, Manuel Sluijter, Joost P G Thum, Thomas Tschöpe, Carsten Zannad, Faiez Zimmermann, Wolfram-Hubertus Ruschitzka, Frank Filippatos, Gerasimos Lindsey, Merry L Maack, Christoph Heymans, Stephane Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
topic_facet |
Biomarkers/blood Cardiac Imaging Techniques/methods Disease Management Europe Extracellular Matrix Proteins/blood Fibrosis/classification Heart Failure/diagnosis Humans Myocardium/metabolism Prognosis Research Societies Medical Translational Medical Research Heart failure Matrix Imaging Fibrosis Biomarkers Fibroblast Cardiology and Cardiovascular Medicine Research Support Non-U.S. Gov't Journal Article |
description |
Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. A lack of pathophysiological insights and uniform definitions has hampered the research in fibrosis and heart failure. The Translational Research Committee of the Heart Failure Association discussed several aspects of fibrosis in their workshop. Early insidious perturbations such as subclinical hypertension or inflammation may trigger first fibrotic events, while more dramatic triggers such as myocardial infarction and myocarditis give rise to full blown scar formation and ongoing fibrosis in diseased hearts. Aging itself is also associated with a cardiac phenotype that includes fibrosis. Fibrosis is an extremely heterogeneous phenomenon, as several stages of the fibrotic process exist, each with different fibrosis subtypes and a different composition of various cells and proteins - resulting in a very complex pathophysiology. As a result, detection of fibrosis, e.g. using current cardiac imaging modalities or plasma biomarkers, will detect only specific subforms of fibrosis, but cannot capture all aspects of the complex fibrotic process. Furthermore, several anti-fibrotic therapies are under investigation, but such therapies generally target aspecific aspects of the fibrotic process and suffer from a lack of precision. This review discusses the mechanisms and the caveats and proposes a roadmap for future research. |
author2 |
Onderzoek Cardiovasculair Reg. Med. Circulatory Health Regenerative Medicine and Stem Cells |
format |
Article in Journal/Newspaper |
author |
de Boer, Rudolf A De Keulenaer, Gilles Bauersachs, Johann Brutsaert, Dirk Cleland, John G Diez, Javier Du, Xiao-Jun Ford, Paul Heinzel, Frank R Lipson, Kenneth E McDonagh, Theresa Lopez-Andres, Natalia Lunde, Ida G Lyon, Alexander R Pollesello, Piero Prasad, Sanjay K Tocchetti, Carlo G Mayr, Manuel Sluijter, Joost P G Thum, Thomas Tschöpe, Carsten Zannad, Faiez Zimmermann, Wolfram-Hubertus Ruschitzka, Frank Filippatos, Gerasimos Lindsey, Merry L Maack, Christoph Heymans, Stephane |
author_facet |
de Boer, Rudolf A De Keulenaer, Gilles Bauersachs, Johann Brutsaert, Dirk Cleland, John G Diez, Javier Du, Xiao-Jun Ford, Paul Heinzel, Frank R Lipson, Kenneth E McDonagh, Theresa Lopez-Andres, Natalia Lunde, Ida G Lyon, Alexander R Pollesello, Piero Prasad, Sanjay K Tocchetti, Carlo G Mayr, Manuel Sluijter, Joost P G Thum, Thomas Tschöpe, Carsten Zannad, Faiez Zimmermann, Wolfram-Hubertus Ruschitzka, Frank Filippatos, Gerasimos Lindsey, Merry L Maack, Christoph Heymans, Stephane |
author_sort |
de Boer, Rudolf A |
title |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_short |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_full |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_fullStr |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_full_unstemmed |
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology |
title_sort |
towards better definition, quantification and treatment of fibrosis in heart failure. a scientific roadmap by the committee of translational research of the heart failure association (hfa) of the european society of cardiology |
publishDate |
2019 |
url |
https://dspace.library.uu.nl/handle/1874/390335 |
genre |
SCAR |
genre_facet |
SCAR |
op_relation |
1388-9842 https://dspace.library.uu.nl/handle/1874/390335 |
op_rights |
info:eu-repo/semantics/OpenAccess |
_version_ |
1799488571953905664 |