Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)
BACKGROUND: Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS: In N=79 793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6...
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ftunivutrecht:oai:dspace.library.uu.nl:1874/358408 2024-05-19T07:46:12+00:00 Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M Gianfagna, Francesco Blankenberg, Stefan Njølstad, Inger Vartiainen, Erkki Sans, Susana Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M Mathiesen, Ellisiv B. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. BiomarCaRE Consortium CDL Cluster Onderzoek en Onderwijs Circulatory Health Experimentele Afd. Cardiologie 1 Onderzoek Vrouw Hart & Vaatziekten 2017 application/pdf https://dspace.library.uu.nl/handle/1874/358408 en eng 0009-7322 https://dspace.library.uu.nl/handle/1874/358408 info:eu-repo/semantics/ClosedAccess Adult Age Factors Aged 80 and over Atrial Fibrillation Body Mass Index Cholesterol Clinical Trial Female Follow-Up Studies Humans Male Middle Aged Multicenter Study Norway Observational Study Risk Factors Sex Characteristics Sex Factors Article 2017 ftunivutrecht 2024-04-29T15:11:06Z BACKGROUND: Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS: In N=79 793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6 years; 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Moli-sani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment in Europe), we examined AF incidence, its association with mortality, common risk factors, biomarkers, and prevalent cardiovascular disease, and their attributable risk by sex. Median follow-up time was 12.6 (to a maximum of 28.2) years. RESULTS: Fewer AF cases were observed in women (N=1796; 4.4%), than in men (N=2465; 6.4%). Cardiovascular risk factor distribution and lipid profile at baseline were less beneficial in men than in women, and cardiovascular disease was more prevalent in men. Cumulative incidence increased markedly after the age of 50 years in men and after 60 years in women. The lifetime risk was similar (>30%) for both sexes. Subjects with incident AF had a 3.5-fold risk of death in comparison with those without AF. Multivariable-adjusted models showed sex differences for the association of body mass index and AF (hazard ratio per standard deviation increase, 1.18; 95% confidence interval [CI], 1.12-1.23 in women versus 1.31; 95% CI 1.25-1.38 in men; interaction P value of 0.001). Total cholesterol was inversely associated with incident AF with a greater risk reduction in women (hazard ratio per SD, 0.86; 95% CI, 0.81-0.90 versus 0.92; 95% CI, 0.88-0.97 in men; interaction P value of 0.023). No sex differences were seen for C-reactive protein and N-terminal pro B-type natriuretic peptide. The population-attributable risk of all risk factors combined was 41.9% in women and 46.0% in men. About 20% of the risk was observed for body mass index. CONCLUSIONS: Lifetime risk of AF was high, and AF was strongly associated with ... Article in Journal/Newspaper Northern Sweden Utrecht University Repository |
institution |
Open Polar |
collection |
Utrecht University Repository |
op_collection_id |
ftunivutrecht |
language |
English |
topic |
Adult Age Factors Aged 80 and over Atrial Fibrillation Body Mass Index Cholesterol Clinical Trial Female Follow-Up Studies Humans Male Middle Aged Multicenter Study Norway Observational Study Risk Factors Sex Characteristics Sex Factors |
spellingShingle |
Adult Age Factors Aged 80 and over Atrial Fibrillation Body Mass Index Cholesterol Clinical Trial Female Follow-Up Studies Humans Male Middle Aged Multicenter Study Norway Observational Study Risk Factors Sex Characteristics Sex Factors Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M Gianfagna, Francesco Blankenberg, Stefan Njølstad, Inger Vartiainen, Erkki Sans, Susana Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M Mathiesen, Ellisiv B. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. BiomarCaRE Consortium Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
topic_facet |
Adult Age Factors Aged 80 and over Atrial Fibrillation Body Mass Index Cholesterol Clinical Trial Female Follow-Up Studies Humans Male Middle Aged Multicenter Study Norway Observational Study Risk Factors Sex Characteristics Sex Factors |
description |
BACKGROUND: Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS: In N=79 793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6 years; 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Moli-sani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment in Europe), we examined AF incidence, its association with mortality, common risk factors, biomarkers, and prevalent cardiovascular disease, and their attributable risk by sex. Median follow-up time was 12.6 (to a maximum of 28.2) years. RESULTS: Fewer AF cases were observed in women (N=1796; 4.4%), than in men (N=2465; 6.4%). Cardiovascular risk factor distribution and lipid profile at baseline were less beneficial in men than in women, and cardiovascular disease was more prevalent in men. Cumulative incidence increased markedly after the age of 50 years in men and after 60 years in women. The lifetime risk was similar (>30%) for both sexes. Subjects with incident AF had a 3.5-fold risk of death in comparison with those without AF. Multivariable-adjusted models showed sex differences for the association of body mass index and AF (hazard ratio per standard deviation increase, 1.18; 95% confidence interval [CI], 1.12-1.23 in women versus 1.31; 95% CI 1.25-1.38 in men; interaction P value of 0.001). Total cholesterol was inversely associated with incident AF with a greater risk reduction in women (hazard ratio per SD, 0.86; 95% CI, 0.81-0.90 versus 0.92; 95% CI, 0.88-0.97 in men; interaction P value of 0.023). No sex differences were seen for C-reactive protein and N-terminal pro B-type natriuretic peptide. The population-attributable risk of all risk factors combined was 41.9% in women and 46.0% in men. About 20% of the risk was observed for body mass index. CONCLUSIONS: Lifetime risk of AF was high, and AF was strongly associated with ... |
author2 |
CDL Cluster Onderzoek en Onderwijs Circulatory Health Experimentele Afd. Cardiologie 1 Onderzoek Vrouw Hart & Vaatziekten |
format |
Article in Journal/Newspaper |
author |
Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M Gianfagna, Francesco Blankenberg, Stefan Njølstad, Inger Vartiainen, Erkki Sans, Susana Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M Mathiesen, Ellisiv B. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. BiomarCaRE Consortium |
author_facet |
Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M Gianfagna, Francesco Blankenberg, Stefan Njølstad, Inger Vartiainen, Erkki Sans, Susana Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M Mathiesen, Ellisiv B. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. BiomarCaRE Consortium |
author_sort |
Magnussen, Christina |
title |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_short |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_full |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_fullStr |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_full_unstemmed |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_sort |
sex differences and similarities in atrial fibrillation epidemiology, risk factors, and mortality in community cohorts: results from the biomarcare consortium (biomarker for cardiovascular risk assessment in europe) |
publishDate |
2017 |
url |
https://dspace.library.uu.nl/handle/1874/358408 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
0009-7322 https://dspace.library.uu.nl/handle/1874/358408 |
op_rights |
info:eu-repo/semantics/ClosedAccess |
_version_ |
1799486334913478656 |