Population genetic analysis and genome-wide association study of patellar luxation in a Thai population of Pomeranian dogs

• Main Authors: Wangdee, C, Leegwater, P A J, Heuven, H C M, van Steenbeek, F G, Techakumphu, M, Hazewinkel, H A W
• Other Authors: CSCA AVM, CSCA TR1, dCSCA RMSC-1, dCSCA AVR
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2017
• Subjects: Canis lupus familiaris; Genome-wide association study; Heritability; Prevalence; Patellar luxation; Canis lupus
• Online Access: https://dspace.library.uu.nl/handle/1874/348942

The genetics of patellar luxation (PL) were investigated in Pomeranian dogs presented at the Small Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University. A cohort of 339 Pomeranian dogs, part of a four-generation pedigree of 842 Pomeranians, was screened for PL from 2006 to 2013. PL was present in 77% of the screened dogs, with 84% having bilateral and 16% unilateral luxation. Medial PL was more common (95%) than lateral PL (2%) or bidirectional PL (3%). The risk of PL was similar in male and female dogs (female:male relative risk 1.11, 95% CI 0.98-1.25). The heritability of PL in the screened population was 0.44±0.04 using a threshold model. A genome-wide association study of PL (48 cases and 48 controls) using a high-density SNP array indicated the possible involvement of 15 chromosomal regions, of which CFA05 and CFA32 remained associated in a larger study involving an additional 128 cases and 7 controls. Candidate genes in these regions may be involved in the pathogenesis of PL in Pomeranian dogs.