Hazard quotient profiles used as a risk assessment tool for PFOS and PFOA serum levels in three distinctive European populations
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) blood levels are commonly used as biomarkers of human environmental exposure to these compounds. Many biomonitoring studies indicate 100% detection for PFOS and PFOA thus justifying a concern of possible risk for the most exposed ind...
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ftunivutrecht:oai:dspace.library.uu.nl:1874/329278 2023-07-23T04:19:32+02:00 Hazard quotient profiles used as a risk assessment tool for PFOS and PFOA serum levels in three distinctive European populations Ludwicki, Jan K. Góralczyk, Katarzyna Struciński, Paweł Wojtyniak, Bogdan Rabczenko, Daniel Toft, Gunnar Lindh, Christian H. Jönsson, Bo A G Lenters, Virissa Heederik, Dick Czaja, Katarzyna Hernik, Agnieszka Pedersen, Henning S. Zvyezday, Valentyna Bonde, Jens Peter Risk Assessment of Toxic and Immunomodulatory Agents LS IRAS EEPI GRA (Gezh.risico-analyse) IRAS RATIA-SIB 2015-01-01 image/pdf https://dspace.library.uu.nl/handle/1874/329278 en eng 0160-4120 https://dspace.library.uu.nl/handle/1874/329278 info:eu-repo/semantics/OpenAccess Environmental contaminants Hazard quotients Perfluorooctane sulfonate Perfluorooctanoic acid Risk assessment Serum levels Coronacrisis-Taverne Environmental Science(all) Article 2015 ftunivutrecht 2023-07-02T01:38:32Z Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) blood levels are commonly used as biomarkers of human environmental exposure to these compounds. Many biomonitoring studies indicate 100% detection for PFOS and PFOA thus justifying a concern of possible risk for the most exposed individuals.This study addresses the predictive value of hazard quotients (HQs) calculated on the basis of serum PFOS and PFOA in male and female populations of reproductive age in Greenland, Poland and Ukraine.Overall, 2026 results of PFOS and PFOA serum concentrations (589 males, 1437 females) were obtained from the INUENDO database. HQs were calculated from the actual biomonitoring results and literature-based animal data linking toxicological outcomes and critical PFOS/PFOA serum levels. HQs for serum PFOS were calculated based on Points of Departure (PoD) at 13μgmL-1 (cynomolgus monkeys, 183days, changes in THS and T3) and for PFOA at 7.1μgmL-1 serum (male rats, 90days, hepatocellular necrosis, increased liver weight). Uncertainty factors were applied to reflect interspecies differences and human variability. Serum HQs were expressed as a ratio relative to the point of departure for each PFOS and PFOA. Only in the three cases of males in Greenland were there serum PFOS levels showing HQ values exceeding 1, so indicating that such serum levels may be of concern. The mean serum concentration of PFOS was significantly higher in male than in female populations. Despite significant differences between HQ profiles for PFOS and PFOA in donors from Greenland, Poland and Ukraine, the concentrations of these perfluoroalkylated compounds do not indicate a cause for concern, except for the three aforementioned cases from Greenland.This study demonstrates that the HQ approach can help to interpret human biomonitoring data and thus serve as a valuable tool in further risk assessment priority settings and may also be used as a basis for taking decisions in risk management. Article in Journal/Newspaper Greenland Utrecht University Repository Greenland |
institution |
Open Polar |
collection |
Utrecht University Repository |
op_collection_id |
ftunivutrecht |
language |
English |
topic |
Environmental contaminants Hazard quotients Perfluorooctane sulfonate Perfluorooctanoic acid Risk assessment Serum levels Coronacrisis-Taverne Environmental Science(all) |
spellingShingle |
Environmental contaminants Hazard quotients Perfluorooctane sulfonate Perfluorooctanoic acid Risk assessment Serum levels Coronacrisis-Taverne Environmental Science(all) Ludwicki, Jan K. Góralczyk, Katarzyna Struciński, Paweł Wojtyniak, Bogdan Rabczenko, Daniel Toft, Gunnar Lindh, Christian H. Jönsson, Bo A G Lenters, Virissa Heederik, Dick Czaja, Katarzyna Hernik, Agnieszka Pedersen, Henning S. Zvyezday, Valentyna Bonde, Jens Peter Hazard quotient profiles used as a risk assessment tool for PFOS and PFOA serum levels in three distinctive European populations |
topic_facet |
Environmental contaminants Hazard quotients Perfluorooctane sulfonate Perfluorooctanoic acid Risk assessment Serum levels Coronacrisis-Taverne Environmental Science(all) |
description |
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) blood levels are commonly used as biomarkers of human environmental exposure to these compounds. Many biomonitoring studies indicate 100% detection for PFOS and PFOA thus justifying a concern of possible risk for the most exposed individuals.This study addresses the predictive value of hazard quotients (HQs) calculated on the basis of serum PFOS and PFOA in male and female populations of reproductive age in Greenland, Poland and Ukraine.Overall, 2026 results of PFOS and PFOA serum concentrations (589 males, 1437 females) were obtained from the INUENDO database. HQs were calculated from the actual biomonitoring results and literature-based animal data linking toxicological outcomes and critical PFOS/PFOA serum levels. HQs for serum PFOS were calculated based on Points of Departure (PoD) at 13μgmL-1 (cynomolgus monkeys, 183days, changes in THS and T3) and for PFOA at 7.1μgmL-1 serum (male rats, 90days, hepatocellular necrosis, increased liver weight). Uncertainty factors were applied to reflect interspecies differences and human variability. Serum HQs were expressed as a ratio relative to the point of departure for each PFOS and PFOA. Only in the three cases of males in Greenland were there serum PFOS levels showing HQ values exceeding 1, so indicating that such serum levels may be of concern. The mean serum concentration of PFOS was significantly higher in male than in female populations. Despite significant differences between HQ profiles for PFOS and PFOA in donors from Greenland, Poland and Ukraine, the concentrations of these perfluoroalkylated compounds do not indicate a cause for concern, except for the three aforementioned cases from Greenland.This study demonstrates that the HQ approach can help to interpret human biomonitoring data and thus serve as a valuable tool in further risk assessment priority settings and may also be used as a basis for taking decisions in risk management. |
author2 |
Risk Assessment of Toxic and Immunomodulatory Agents LS IRAS EEPI GRA (Gezh.risico-analyse) IRAS RATIA-SIB |
format |
Article in Journal/Newspaper |
author |
Ludwicki, Jan K. Góralczyk, Katarzyna Struciński, Paweł Wojtyniak, Bogdan Rabczenko, Daniel Toft, Gunnar Lindh, Christian H. Jönsson, Bo A G Lenters, Virissa Heederik, Dick Czaja, Katarzyna Hernik, Agnieszka Pedersen, Henning S. Zvyezday, Valentyna Bonde, Jens Peter |
author_facet |
Ludwicki, Jan K. Góralczyk, Katarzyna Struciński, Paweł Wojtyniak, Bogdan Rabczenko, Daniel Toft, Gunnar Lindh, Christian H. Jönsson, Bo A G Lenters, Virissa Heederik, Dick Czaja, Katarzyna Hernik, Agnieszka Pedersen, Henning S. Zvyezday, Valentyna Bonde, Jens Peter |
author_sort |
Ludwicki, Jan K. |
title |
Hazard quotient profiles used as a risk assessment tool for PFOS and PFOA serum levels in three distinctive European populations |
title_short |
Hazard quotient profiles used as a risk assessment tool for PFOS and PFOA serum levels in three distinctive European populations |
title_full |
Hazard quotient profiles used as a risk assessment tool for PFOS and PFOA serum levels in three distinctive European populations |
title_fullStr |
Hazard quotient profiles used as a risk assessment tool for PFOS and PFOA serum levels in three distinctive European populations |
title_full_unstemmed |
Hazard quotient profiles used as a risk assessment tool for PFOS and PFOA serum levels in three distinctive European populations |
title_sort |
hazard quotient profiles used as a risk assessment tool for pfos and pfoa serum levels in three distinctive european populations |
publishDate |
2015 |
url |
https://dspace.library.uu.nl/handle/1874/329278 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_relation |
0160-4120 https://dspace.library.uu.nl/handle/1874/329278 |
op_rights |
info:eu-repo/semantics/OpenAccess |
_version_ |
1772182714827407360 |