Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study
OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and body mass index (BMI) z-scores i...
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ftunivutrecht:oai:dspace.library.uu.nl:1874/305143 2023-11-12T04:18:01+01:00 Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study Hoyer, B. B. Ramlau-Hansen, C. H. Henriksen, T. B. Pedersen, H. S. Goralczyk, K. Zviezdai, V. Jonsson, B. A. G. Heederik, D. Lenters, V. Vermeulen, R. Bonde, J. P. Toft, G. Risk Assessment of Toxic and Immunomodulatory Agents LS IRAS EEPI GRA (Gezh.risico-analyse) IRAS RATIA-SIB UU LEG Research USE Tjalling C. Koopmans Institute 2014-07 application/pdf https://dspace.library.uu.nl/handle/1874/305143 en eng 0307-0565 https://dspace.library.uu.nl/handle/1874/305143 info:eu-repo/semantics/OpenAccess body mass index child cohort study dichlorodiphenyl dichloroethylene (DDE) polychlorinated biphenyls (PCBs) prenatal exposure delayed effects POLYCHLORINATED-BIPHENYLS PCBS PRENATAL EXPOSURE CHILDHOOD GROWTH THYROID-HORMONE BIRTH COHORT BREAST-MILK 2 CITIES OVERWEIGHT OBESITY DDT Coronacrisis-Taverne Article 2014 ftunivutrecht 2023-11-01T23:12:38Z OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children. METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N = 1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p, p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age-and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis. RESULTS: No clear associations between pregnancy CB-153 and p, p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p, p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) k gm(-2), respectively. CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p, p'-DDE and CB-153 and BMI at the age of 5-9 years. Article in Journal/Newspaper Greenland greenlandic Utrecht University Repository Greenland |
institution |
Open Polar |
collection |
Utrecht University Repository |
op_collection_id |
ftunivutrecht |
language |
English |
topic |
body mass index child cohort study dichlorodiphenyl dichloroethylene (DDE) polychlorinated biphenyls (PCBs) prenatal exposure delayed effects POLYCHLORINATED-BIPHENYLS PCBS PRENATAL EXPOSURE CHILDHOOD GROWTH THYROID-HORMONE BIRTH COHORT BREAST-MILK 2 CITIES OVERWEIGHT OBESITY DDT Coronacrisis-Taverne |
spellingShingle |
body mass index child cohort study dichlorodiphenyl dichloroethylene (DDE) polychlorinated biphenyls (PCBs) prenatal exposure delayed effects POLYCHLORINATED-BIPHENYLS PCBS PRENATAL EXPOSURE CHILDHOOD GROWTH THYROID-HORMONE BIRTH COHORT BREAST-MILK 2 CITIES OVERWEIGHT OBESITY DDT Coronacrisis-Taverne Hoyer, B. B. Ramlau-Hansen, C. H. Henriksen, T. B. Pedersen, H. S. Goralczyk, K. Zviezdai, V. Jonsson, B. A. G. Heederik, D. Lenters, V. Vermeulen, R. Bonde, J. P. Toft, G. Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study |
topic_facet |
body mass index child cohort study dichlorodiphenyl dichloroethylene (DDE) polychlorinated biphenyls (PCBs) prenatal exposure delayed effects POLYCHLORINATED-BIPHENYLS PCBS PRENATAL EXPOSURE CHILDHOOD GROWTH THYROID-HORMONE BIRTH COHORT BREAST-MILK 2 CITIES OVERWEIGHT OBESITY DDT Coronacrisis-Taverne |
description |
OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children. METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N = 1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p, p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age-and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis. RESULTS: No clear associations between pregnancy CB-153 and p, p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p, p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) k gm(-2), respectively. CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p, p'-DDE and CB-153 and BMI at the age of 5-9 years. |
author2 |
Risk Assessment of Toxic and Immunomodulatory Agents LS IRAS EEPI GRA (Gezh.risico-analyse) IRAS RATIA-SIB UU LEG Research USE Tjalling C. Koopmans Institute |
format |
Article in Journal/Newspaper |
author |
Hoyer, B. B. Ramlau-Hansen, C. H. Henriksen, T. B. Pedersen, H. S. Goralczyk, K. Zviezdai, V. Jonsson, B. A. G. Heederik, D. Lenters, V. Vermeulen, R. Bonde, J. P. Toft, G. |
author_facet |
Hoyer, B. B. Ramlau-Hansen, C. H. Henriksen, T. B. Pedersen, H. S. Goralczyk, K. Zviezdai, V. Jonsson, B. A. G. Heederik, D. Lenters, V. Vermeulen, R. Bonde, J. P. Toft, G. |
author_sort |
Hoyer, B. B. |
title |
Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study |
title_short |
Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study |
title_full |
Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study |
title_fullStr |
Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study |
title_full_unstemmed |
Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study |
title_sort |
body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study |
publishDate |
2014 |
url |
https://dspace.library.uu.nl/handle/1874/305143 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlandic |
genre_facet |
Greenland greenlandic |
op_relation |
0307-0565 https://dspace.library.uu.nl/handle/1874/305143 |
op_rights |
info:eu-repo/semantics/OpenAccess |
_version_ |
1782334749281353728 |