Cold Adaptation in Antarctic Notothenioids: Comparative Transcriptomics Reveals Novel Insights in the Peculiar Role of Gills and Highlights Signatures of Cobalamin Deficiency
Far from being devoid of life, Antarctic waters are home to Cryonotothenioidea, which represent one of the fascinating cases of evolutionary adaptation to extreme environmental conditions in vertebrates. Thanks to a series of unique morphological and physiological peculiarities, which include the pa...
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ftunivtuscia:oai:dspace.unitus.it:2067/43179 2023-05-15T13:52:30+02:00 Cold Adaptation in Antarctic Notothenioids: Comparative Transcriptomics Reveals Novel Insights in the Peculiar Role of Gills and Highlights Signatures of Cobalamin Deficiency Ansaloni, Federico Gerdol, Marco Torboli, Valentina Fornaini, Nicola Reinaldo Greco, Samuele Giulianini, Piero Giulio Coscia, Maria Rosaria Miccoli, Andrea Santovito, Gianfranco Buonocore, Francesco Scapigliati, Giuseppe Pallavicini, Alberto ITA 2021 ELETTRONICO http://hdl.handle.net/2067/43179 https://doi.org/10.3390/ijms22041812 https://api.elsevier.com/content/abstract/scopus_id/85100695339 en eng INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1 22 4 1422-0067 http://hdl.handle.net/2067/43179 doi:10.3390/ijms22041812 33670421 2-s2.0-85100695339 000623777900001 https://api.elsevier.com/content/abstract/scopus_id/85100695339 restricted article 2021 ftunivtuscia https://doi.org/10.3390/ijms22041812 2022-05-01T15:19:52Z Far from being devoid of life, Antarctic waters are home to Cryonotothenioidea, which represent one of the fascinating cases of evolutionary adaptation to extreme environmental conditions in vertebrates. Thanks to a series of unique morphological and physiological peculiarities, which include the paradigmatic case of loss of hemoglobin in the family Channichthyidae, these fish survive and thrive at sub-zero temperatures. While some of the distinctive features of such adaptations have been known for decades, our knowledge of their genetic and molecular bases is still limited. We generated a reference de novo assembly of the icefish Chionodraco hamatus transcriptome and used this resource for a large-scale comparative analysis among five red-blooded Cryonotothenioidea, the sub-Antarctic notothenioid Eleginops maclovinus and seven temperate teleost species. Our investigation targeted the gills, a tissue of primary importance for gaseous exchange, osmoregulation, ammonia excretion, and its role in fish immunity. One hundred and twenty genes were identified as significantly up-regulated in Antarctic species and surprisingly shared by red- and white-blooded notothenioids, unveiling several previously unreported molecular players that might have contributed to the evolutionary success of Cryonotothenioidea in Antarctica. In particular, we detected cobalamin deficiency signatures and discussed the possible biological implications of this condition concerning hematological alterations and the heavy parasitic loads typically observed in all Cryonotothenioidea. 12 no Article in Journal/Newspaper Antarc* Antarctic Antarctica Icefish Università degli studi della Tuscia: Unitus DSpace Antarctic International Journal of Molecular Sciences 22 4 1812 |
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Università degli studi della Tuscia: Unitus DSpace |
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English |
description |
Far from being devoid of life, Antarctic waters are home to Cryonotothenioidea, which represent one of the fascinating cases of evolutionary adaptation to extreme environmental conditions in vertebrates. Thanks to a series of unique morphological and physiological peculiarities, which include the paradigmatic case of loss of hemoglobin in the family Channichthyidae, these fish survive and thrive at sub-zero temperatures. While some of the distinctive features of such adaptations have been known for decades, our knowledge of their genetic and molecular bases is still limited. We generated a reference de novo assembly of the icefish Chionodraco hamatus transcriptome and used this resource for a large-scale comparative analysis among five red-blooded Cryonotothenioidea, the sub-Antarctic notothenioid Eleginops maclovinus and seven temperate teleost species. Our investigation targeted the gills, a tissue of primary importance for gaseous exchange, osmoregulation, ammonia excretion, and its role in fish immunity. One hundred and twenty genes were identified as significantly up-regulated in Antarctic species and surprisingly shared by red- and white-blooded notothenioids, unveiling several previously unreported molecular players that might have contributed to the evolutionary success of Cryonotothenioidea in Antarctica. In particular, we detected cobalamin deficiency signatures and discussed the possible biological implications of this condition concerning hematological alterations and the heavy parasitic loads typically observed in all Cryonotothenioidea. 12 no |
author2 |
ITA |
format |
Article in Journal/Newspaper |
author |
Ansaloni, Federico Gerdol, Marco Torboli, Valentina Fornaini, Nicola Reinaldo Greco, Samuele Giulianini, Piero Giulio Coscia, Maria Rosaria Miccoli, Andrea Santovito, Gianfranco Buonocore, Francesco Scapigliati, Giuseppe Pallavicini, Alberto |
spellingShingle |
Ansaloni, Federico Gerdol, Marco Torboli, Valentina Fornaini, Nicola Reinaldo Greco, Samuele Giulianini, Piero Giulio Coscia, Maria Rosaria Miccoli, Andrea Santovito, Gianfranco Buonocore, Francesco Scapigliati, Giuseppe Pallavicini, Alberto Cold Adaptation in Antarctic Notothenioids: Comparative Transcriptomics Reveals Novel Insights in the Peculiar Role of Gills and Highlights Signatures of Cobalamin Deficiency |
author_facet |
Ansaloni, Federico Gerdol, Marco Torboli, Valentina Fornaini, Nicola Reinaldo Greco, Samuele Giulianini, Piero Giulio Coscia, Maria Rosaria Miccoli, Andrea Santovito, Gianfranco Buonocore, Francesco Scapigliati, Giuseppe Pallavicini, Alberto |
author_sort |
Ansaloni, Federico |
title |
Cold Adaptation in Antarctic Notothenioids: Comparative Transcriptomics Reveals Novel Insights in the Peculiar Role of Gills and Highlights Signatures of Cobalamin Deficiency |
title_short |
Cold Adaptation in Antarctic Notothenioids: Comparative Transcriptomics Reveals Novel Insights in the Peculiar Role of Gills and Highlights Signatures of Cobalamin Deficiency |
title_full |
Cold Adaptation in Antarctic Notothenioids: Comparative Transcriptomics Reveals Novel Insights in the Peculiar Role of Gills and Highlights Signatures of Cobalamin Deficiency |
title_fullStr |
Cold Adaptation in Antarctic Notothenioids: Comparative Transcriptomics Reveals Novel Insights in the Peculiar Role of Gills and Highlights Signatures of Cobalamin Deficiency |
title_full_unstemmed |
Cold Adaptation in Antarctic Notothenioids: Comparative Transcriptomics Reveals Novel Insights in the Peculiar Role of Gills and Highlights Signatures of Cobalamin Deficiency |
title_sort |
cold adaptation in antarctic notothenioids: comparative transcriptomics reveals novel insights in the peculiar role of gills and highlights signatures of cobalamin deficiency |
publishDate |
2021 |
url |
http://hdl.handle.net/2067/43179 https://doi.org/10.3390/ijms22041812 https://api.elsevier.com/content/abstract/scopus_id/85100695339 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctica Icefish |
genre_facet |
Antarc* Antarctic Antarctica Icefish |
op_relation |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1 22 4 1422-0067 http://hdl.handle.net/2067/43179 doi:10.3390/ijms22041812 33670421 2-s2.0-85100695339 000623777900001 https://api.elsevier.com/content/abstract/scopus_id/85100695339 |
op_rights |
restricted |
op_doi |
https://doi.org/10.3390/ijms22041812 |
container_title |
International Journal of Molecular Sciences |
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22 |
container_issue |
4 |
container_start_page |
1812 |
_version_ |
1766256814356168704 |