Biotransformation and endocrine disruptive effects of contaminants in ringed seals - implications for monitoring and risk assessment
Marine mammals are exposed to persistent organic pollutants (POPs), which may be biotransformed to metabolites some of which are highly toxic. Both POPs and their metabolites may lead to adverse health effects, which have been studied using various biomarkers. Changes in endocrine homeostasis have b...
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Turun yliopisto, University of Turku
2009
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ftunivturku:oai:www.utupub.fi:10024/50251 2024-09-15T18:32:23+00:00 Biotransformation and endocrine disruptive effects of contaminants in ringed seals - implications for monitoring and risk assessment Routti, Heli Matemaattis-luonnontieteellinen tiedekunta, Faculty of Mathematics and Natural Sciences Biologian laitos, Department of Biology Matemaattis-luonnontieteellinen tiedekunta / Faculty of Mathematics and Natural Sciences, Department of Biology 2009-11-06 fulltext http://www.utupub.fi/handle/10024/50251 eng eng Turun yliopisto, University of Turku Annales Universitatis Turkuensis A II 243 Turun yliopiston julkaisuja. Sarja AII, Biologica - Geographica – Geologica 2343-3183 243 ISBN 978-951-29-4085-1 http://www.utupub.fi/handle/10024/50251 URN:ISBN:978-951-29-4085-1 Artikkeliväitöskirja, Doctoral dissertation (article-based) 2009 ftunivturku 2024-08-01T03:14:27Z Marine mammals are exposed to persistent organic pollutants (POPs), which may be biotransformed to metabolites some of which are highly toxic. Both POPs and their metabolites may lead to adverse health effects, which have been studied using various biomarkers. Changes in endocrine homeostasis have been suggested to be sensitive biomarkers for contaminant-related effects. The overall objective of this doctoral thesis was to investigate biotransformation capacity of POPs and their potential endocrine disruptive effects in two contrasting ringed seal populations from the low contaminated Svalbard area and from the highly contaminated Baltic Sea. Biotransformation capacity was studied by determining the relationships between congener-specific patterns and concentrations of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs) and their hydroxyl (OH)- and/or methylsulfonyl (MeSO 2 )-metabolites, and catalytic activities of hepatic xenobiotic-metabolizing phase I and II enzymes. The results suggest that the biotransformation of PCBs, PBDEs and toxaphenes in ringed seals depends on the congener-specific halogen-substitution pattern. Biotransformation products detected in the seals included OH-PCBs, MeSO 2 -PCBs and –DDE, pentachlorophenol, 4-OHheptachlorostyrene, and to a minor extent OH-PBDEs. The effects of life history state (moulting and fasting) on contaminant status and potential biomarkers for endocrine disruption, including hormone and vitamin homeostasis, were investigated in the low contaminated ringed seal population from Svalbard. Moulting/fasting status strongly affected thyroid, vitamin A and calcitriol homeostasis, body condition and concentrations of POPs and their OH-metabolites. In contrast, moulting/fasting status was not associated with variations in vitamin E levels. Endocrine disruptive effects on multiple endpoints were investigated in the two contrasting ringed seal populations. The results suggest that thyroid, vitamin A and calcitriol ... Other/Unknown Material ringed seal Svalbard University of Turku: UTUPub |
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University of Turku: UTUPub |
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language |
English |
description |
Marine mammals are exposed to persistent organic pollutants (POPs), which may be biotransformed to metabolites some of which are highly toxic. Both POPs and their metabolites may lead to adverse health effects, which have been studied using various biomarkers. Changes in endocrine homeostasis have been suggested to be sensitive biomarkers for contaminant-related effects. The overall objective of this doctoral thesis was to investigate biotransformation capacity of POPs and their potential endocrine disruptive effects in two contrasting ringed seal populations from the low contaminated Svalbard area and from the highly contaminated Baltic Sea. Biotransformation capacity was studied by determining the relationships between congener-specific patterns and concentrations of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs) and their hydroxyl (OH)- and/or methylsulfonyl (MeSO 2 )-metabolites, and catalytic activities of hepatic xenobiotic-metabolizing phase I and II enzymes. The results suggest that the biotransformation of PCBs, PBDEs and toxaphenes in ringed seals depends on the congener-specific halogen-substitution pattern. Biotransformation products detected in the seals included OH-PCBs, MeSO 2 -PCBs and –DDE, pentachlorophenol, 4-OHheptachlorostyrene, and to a minor extent OH-PBDEs. The effects of life history state (moulting and fasting) on contaminant status and potential biomarkers for endocrine disruption, including hormone and vitamin homeostasis, were investigated in the low contaminated ringed seal population from Svalbard. Moulting/fasting status strongly affected thyroid, vitamin A and calcitriol homeostasis, body condition and concentrations of POPs and their OH-metabolites. In contrast, moulting/fasting status was not associated with variations in vitamin E levels. Endocrine disruptive effects on multiple endpoints were investigated in the two contrasting ringed seal populations. The results suggest that thyroid, vitamin A and calcitriol ... |
author2 |
Matemaattis-luonnontieteellinen tiedekunta, Faculty of Mathematics and Natural Sciences Biologian laitos, Department of Biology Matemaattis-luonnontieteellinen tiedekunta / Faculty of Mathematics and Natural Sciences, Department of Biology |
format |
Other/Unknown Material |
author |
Routti, Heli |
spellingShingle |
Routti, Heli Biotransformation and endocrine disruptive effects of contaminants in ringed seals - implications for monitoring and risk assessment |
author_facet |
Routti, Heli |
author_sort |
Routti, Heli |
title |
Biotransformation and endocrine disruptive effects of contaminants in ringed seals - implications for monitoring and risk assessment |
title_short |
Biotransformation and endocrine disruptive effects of contaminants in ringed seals - implications for monitoring and risk assessment |
title_full |
Biotransformation and endocrine disruptive effects of contaminants in ringed seals - implications for monitoring and risk assessment |
title_fullStr |
Biotransformation and endocrine disruptive effects of contaminants in ringed seals - implications for monitoring and risk assessment |
title_full_unstemmed |
Biotransformation and endocrine disruptive effects of contaminants in ringed seals - implications for monitoring and risk assessment |
title_sort |
biotransformation and endocrine disruptive effects of contaminants in ringed seals - implications for monitoring and risk assessment |
publisher |
Turun yliopisto, University of Turku |
publishDate |
2009 |
url |
http://www.utupub.fi/handle/10024/50251 |
genre |
ringed seal Svalbard |
genre_facet |
ringed seal Svalbard |
op_relation |
Turun yliopiston julkaisuja. Sarja AII, Biologica - Geographica – Geologica 2343-3183 243 ISBN 978-951-29-4085-1 http://www.utupub.fi/handle/10024/50251 URN:ISBN:978-951-29-4085-1 |
_version_ |
1810474112326303744 |