Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness
Objective: The elevated prevalence of cardiometabolic disorders is consistently reported in patients with severe mental illness (SMI). We explored the association between parental SMI and offspring cardiometabolic morbidity. Our hypothesis was that offspring of people with SMI have increased morbidi...
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LIPPINCOTT WILLIAMS & WILKINS
2022
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ftunivturku:oai:www.utupub.fi:10024/171518 2023-05-15T17:42:36+02:00 Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness Jones Peter B Veijola Juha Protsenko Maria Auvinen Juha Kerkela Martta Miettunen Jouko Jarvelin Marjo-Riitta Gissler Mika lastenpsykiatrian tutkimuskeskus, Lastenpsykiatrian tutkimuskeskus 2607326 2022-10-28T14:27:55Z 9 2 https://www.utupub.fi/handle/10024/171518 https://journals.lww.com/psychosomaticmedicine/Fulltext/2022/01000/Cardiometabolic_Disorders_in_the_Offspring_of.2.aspx en eng LIPPINCOTT WILLIAMS & WILKINS United States Yhdysvallat (USA) US 84 10.1097/PSY.0000000000001022 Psychosomatic Medicine https://www.utupub.fi/handle/10024/171518 https://journals.lww.com/psychosomaticmedicine/Fulltext/2022/01000/Cardiometabolic_Disorders_in_the_Offspring_of.2.aspx URN:NBN:fi-fe2022081155009 0033-3174 2022 ftunivturku 2022-11-03T00:02:43Z Objective: The elevated prevalence of cardiometabolic disorders is consistently reported in patients with severe mental illness (SMI). We explored the association between parental SMI and offspring cardiometabolic morbidity. Our hypothesis was that offspring of people with SMI have increased morbidity risk. Method: The Northern Finland Birth Cohort 1966 is a study of offspring whose date of birth was expected in 1966. The follow-up lasted until 2015 (49 years). The final study sample included 11,175 children. We used parental SMI as the exposure in the study. The following cardiometabolic disorders were used as outcome measures: diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, obesity, and cerebrovascular disorders. Results: There were 139 (14.7%; hazard ratios [HR] = 1.63; 95% confidence interval [CI] = 1.36-1.94) children of parents with SMI who developed cardiometabolic disorder during follow-up and 957 (9.4%) in the comparison cohort. Statistically significant HRs were found in males (HR = 1.95; 95% CI =1.56-2.44), but not in females (HR = 1.29; 95% CI = 0.96-1.73). Conclusions: Having a cardiometabolic disorder was associated with male offspring of parents with SMI. Our findings suggest that there is an elevated risk of coronary artery disease, hyperlipidemia, obesity, and hypertension in the male offspring of parents with SMI. Our results suggest that the somatic health of offspring of parents with SMI should also be considered in addition to their mental health in clinical practice. Other/Unknown Material Northern Finland University of Turku: UTUPub |
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University of Turku: UTUPub |
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English |
description |
Objective: The elevated prevalence of cardiometabolic disorders is consistently reported in patients with severe mental illness (SMI). We explored the association between parental SMI and offspring cardiometabolic morbidity. Our hypothesis was that offspring of people with SMI have increased morbidity risk. Method: The Northern Finland Birth Cohort 1966 is a study of offspring whose date of birth was expected in 1966. The follow-up lasted until 2015 (49 years). The final study sample included 11,175 children. We used parental SMI as the exposure in the study. The following cardiometabolic disorders were used as outcome measures: diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, obesity, and cerebrovascular disorders. Results: There were 139 (14.7%; hazard ratios [HR] = 1.63; 95% confidence interval [CI] = 1.36-1.94) children of parents with SMI who developed cardiometabolic disorder during follow-up and 957 (9.4%) in the comparison cohort. Statistically significant HRs were found in males (HR = 1.95; 95% CI =1.56-2.44), but not in females (HR = 1.29; 95% CI = 0.96-1.73). Conclusions: Having a cardiometabolic disorder was associated with male offspring of parents with SMI. Our findings suggest that there is an elevated risk of coronary artery disease, hyperlipidemia, obesity, and hypertension in the male offspring of parents with SMI. Our results suggest that the somatic health of offspring of parents with SMI should also be considered in addition to their mental health in clinical practice. |
author2 |
lastenpsykiatrian tutkimuskeskus, Lastenpsykiatrian tutkimuskeskus 2607326 |
author |
Jones Peter B Veijola Juha Protsenko Maria Auvinen Juha Kerkela Martta Miettunen Jouko Jarvelin Marjo-Riitta Gissler Mika |
spellingShingle |
Jones Peter B Veijola Juha Protsenko Maria Auvinen Juha Kerkela Martta Miettunen Jouko Jarvelin Marjo-Riitta Gissler Mika Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness |
author_facet |
Jones Peter B Veijola Juha Protsenko Maria Auvinen Juha Kerkela Martta Miettunen Jouko Jarvelin Marjo-Riitta Gissler Mika |
author_sort |
Jones Peter B |
title |
Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness |
title_short |
Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness |
title_full |
Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness |
title_fullStr |
Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness |
title_full_unstemmed |
Cardiometabolic Disorders in the Offspring of Parents With Severe Mental Illness |
title_sort |
cardiometabolic disorders in the offspring of parents with severe mental illness |
publisher |
LIPPINCOTT WILLIAMS & WILKINS |
publishDate |
2022 |
url |
https://www.utupub.fi/handle/10024/171518 https://journals.lww.com/psychosomaticmedicine/Fulltext/2022/01000/Cardiometabolic_Disorders_in_the_Offspring_of.2.aspx |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
84 10.1097/PSY.0000000000001022 Psychosomatic Medicine https://www.utupub.fi/handle/10024/171518 https://journals.lww.com/psychosomaticmedicine/Fulltext/2022/01000/Cardiometabolic_Disorders_in_the_Offspring_of.2.aspx URN:NBN:fi-fe2022081155009 0033-3174 |
_version_ |
1766144491954110464 |