Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm
Abstract Objective It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design The ESTER Preterm...
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European society of endocrinology
2022
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ftunivturku:oai:www.utupub.fi:10024/156421 2023-05-15T17:42:20+02:00 Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm Eriksson Johan Järvelin Marjo-Riitta Kajantie Eero Matinolli Hanna-Maria Morin-Papunen Laure Mustaniemi Sanna Paalanne Marika Tikanmäki Marjaana Vääräsmäki Marja Wehkalampi Karoliina PÄÄT INVEST Lippulaiva Lastenpsykiatria, PÄÄT INVEST Flagship Child Psychiatry lastenpsykiatrian tutkimuskeskus, Lastenpsykiatrian tutkimuskeskus 2603023 2607326 2022-10-27T11:59:19Z 279 288 https://www.utupub.fi/handle/10024/156421 https://eje.bioscientifica.com/view/journals/eje/185/2/EJE-20-1462.xml en eng European society of endocrinology United Kingdom Britannia GB 185 10.1530/EJE-20-1462 European Journal of Endocrinology 2 https://www.utupub.fi/handle/10024/156421 https://eje.bioscientifica.com/view/journals/eje/185/2/EJE-20-1462.xml URN:NBN:fi-fe2021093047956 1479-683X 0804-4643 2022 ftunivturku 2022-11-30T23:59:47Z Abstract Objective It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34–36 weeks, LPT), and 184 born full term (≥37 weeks, controls) were included in the analysis (mean age: 23.2 years). Methods We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L). Results Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (−2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject’s birth weight s.d. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). Conclusions Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term. Other/Unknown Material Northern Finland University of Turku: UTUPub |
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University of Turku: UTUPub |
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English |
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Abstract Objective It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34–36 weeks, LPT), and 184 born full term (≥37 weeks, controls) were included in the analysis (mean age: 23.2 years). Methods We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L). Results Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (−2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject’s birth weight s.d. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). Conclusions Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term. |
author2 |
PÄÄT INVEST Lippulaiva Lastenpsykiatria, PÄÄT INVEST Flagship Child Psychiatry lastenpsykiatrian tutkimuskeskus, Lastenpsykiatrian tutkimuskeskus 2603023 2607326 |
author |
Eriksson Johan Järvelin Marjo-Riitta Kajantie Eero Matinolli Hanna-Maria Morin-Papunen Laure Mustaniemi Sanna Paalanne Marika Tikanmäki Marjaana Vääräsmäki Marja Wehkalampi Karoliina |
spellingShingle |
Eriksson Johan Järvelin Marjo-Riitta Kajantie Eero Matinolli Hanna-Maria Morin-Papunen Laure Mustaniemi Sanna Paalanne Marika Tikanmäki Marjaana Vääräsmäki Marja Wehkalampi Karoliina Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
author_facet |
Eriksson Johan Järvelin Marjo-Riitta Kajantie Eero Matinolli Hanna-Maria Morin-Papunen Laure Mustaniemi Sanna Paalanne Marika Tikanmäki Marjaana Vääräsmäki Marja Wehkalampi Karoliina |
author_sort |
Eriksson Johan |
title |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_short |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_full |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_fullStr |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_full_unstemmed |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_sort |
clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
publisher |
European society of endocrinology |
publishDate |
2022 |
url |
https://www.utupub.fi/handle/10024/156421 https://eje.bioscientifica.com/view/journals/eje/185/2/EJE-20-1462.xml |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
185 10.1530/EJE-20-1462 European Journal of Endocrinology 2 https://www.utupub.fi/handle/10024/156421 https://eje.bioscientifica.com/view/journals/eje/185/2/EJE-20-1462.xml URN:NBN:fi-fe2021093047956 1479-683X 0804-4643 |
_version_ |
1766144186200883200 |