Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study
Background: Vertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk. Methods...
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ftunivtsydney:oai:opus.lib.uts.edu.au:10453/28801 2023-05-15T18:34:34+02:00 Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study Waterloo, S Nguyen, T Ahmed, LA Center, JR Morseth, B Nguyen, ND Eisman, JA Søgaard, AJ Emaus, N 2012-09-03 application/pdf http://hdl.handle.net/10453/28801 unknown BMC Musculoskeletal Disorders 10.1186/1471-2474-13-163 BMC Musculoskeletal Disorders, 2012, 13 http://hdl.handle.net/10453/28801 Orthopedics Lumbar Vertebrae Thoracic Vertebrae Hip Joint Humans Osteoporosis Spinal Fractures Absorptiometry Photon Questionnaires Prevalence Multivariate Analysis Logistic Models Odds Ratio Risk Assessment Risk Factors Chi-Square Distribution Cross-Sectional Studies Life Style Age Factors Sex Factors Bone Density Adult Aged 80 and over Middle Aged Norway Female Male Surveys and Questionnaires Journal Article 2012 ftunivtsydney 2022-03-13T13:34:33Z Background: Vertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk. Methods. Vertebral fracture was ascertained by VFA method (DXA, GE Lunar Prodigy) in 2887 men and women, aged between 38 and 87 years, in the population-based Tromsø Study 2007/2008. Bone mineral density (BMD; g/cm2) at the hip was measured by DXA. Lifestyle information was collected by questionnaires. Multivariable logistic regression model, with anthropometric and lifestyle factors included, was used to assess the association between each or combined risk factors and vertebral fracture risk. Population attributable risk was estimated for combined risk factors in the final multivariable model. Results: In both sexes, age (odds ratio [OR] per 5 year increase: 1.32; 95% CI 1.19-1.45 in women and 1.21; 95% CI 1.10-1.33 in men) and BMD (OR per SD decrease: 1.60; 95% CI 1.34-1.90 in women and1.40; 95% CI 1.18-1.67 in men) were independent risk factors for vertebral fracture. At BMD levels higher than 0.85 g/cm2, men had a greater risk of fracture than women (OR 1.52; 95% CI 1.14-2.04), after adjusting for age. In women and men, respectively, approximately 46% and 33% of vertebral fracture risk was attributable to advancing age (more than 70 years) and low BMD (less than 0.85 g/cm 2), with the latter having a greater effect than the former. Conclusions: These data confirm that age and BMD are major risk factors for vertebral fracture risk. However, in both sexes the two factors accounted for less than half of fracture risk. The identification of individuals with vertebral fracture is still a challenge. © 2012 Waterloo et al.; licensee BioMed Central Ltd. Article in Journal/Newspaper Tromsø University of Technology Sydney: OPUS - Open Publications of UTS Scholars Norway Tromsø |
institution |
Open Polar |
collection |
University of Technology Sydney: OPUS - Open Publications of UTS Scholars |
op_collection_id |
ftunivtsydney |
language |
unknown |
topic |
Orthopedics Lumbar Vertebrae Thoracic Vertebrae Hip Joint Humans Osteoporosis Spinal Fractures Absorptiometry Photon Questionnaires Prevalence Multivariate Analysis Logistic Models Odds Ratio Risk Assessment Risk Factors Chi-Square Distribution Cross-Sectional Studies Life Style Age Factors Sex Factors Bone Density Adult Aged 80 and over Middle Aged Norway Female Male Surveys and Questionnaires |
spellingShingle |
Orthopedics Lumbar Vertebrae Thoracic Vertebrae Hip Joint Humans Osteoporosis Spinal Fractures Absorptiometry Photon Questionnaires Prevalence Multivariate Analysis Logistic Models Odds Ratio Risk Assessment Risk Factors Chi-Square Distribution Cross-Sectional Studies Life Style Age Factors Sex Factors Bone Density Adult Aged 80 and over Middle Aged Norway Female Male Surveys and Questionnaires Waterloo, S Nguyen, T Ahmed, LA Center, JR Morseth, B Nguyen, ND Eisman, JA Søgaard, AJ Emaus, N Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
topic_facet |
Orthopedics Lumbar Vertebrae Thoracic Vertebrae Hip Joint Humans Osteoporosis Spinal Fractures Absorptiometry Photon Questionnaires Prevalence Multivariate Analysis Logistic Models Odds Ratio Risk Assessment Risk Factors Chi-Square Distribution Cross-Sectional Studies Life Style Age Factors Sex Factors Bone Density Adult Aged 80 and over Middle Aged Norway Female Male Surveys and Questionnaires |
description |
Background: Vertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk. Methods. Vertebral fracture was ascertained by VFA method (DXA, GE Lunar Prodigy) in 2887 men and women, aged between 38 and 87 years, in the population-based Tromsø Study 2007/2008. Bone mineral density (BMD; g/cm2) at the hip was measured by DXA. Lifestyle information was collected by questionnaires. Multivariable logistic regression model, with anthropometric and lifestyle factors included, was used to assess the association between each or combined risk factors and vertebral fracture risk. Population attributable risk was estimated for combined risk factors in the final multivariable model. Results: In both sexes, age (odds ratio [OR] per 5 year increase: 1.32; 95% CI 1.19-1.45 in women and 1.21; 95% CI 1.10-1.33 in men) and BMD (OR per SD decrease: 1.60; 95% CI 1.34-1.90 in women and1.40; 95% CI 1.18-1.67 in men) were independent risk factors for vertebral fracture. At BMD levels higher than 0.85 g/cm2, men had a greater risk of fracture than women (OR 1.52; 95% CI 1.14-2.04), after adjusting for age. In women and men, respectively, approximately 46% and 33% of vertebral fracture risk was attributable to advancing age (more than 70 years) and low BMD (less than 0.85 g/cm 2), with the latter having a greater effect than the former. Conclusions: These data confirm that age and BMD are major risk factors for vertebral fracture risk. However, in both sexes the two factors accounted for less than half of fracture risk. The identification of individuals with vertebral fracture is still a challenge. © 2012 Waterloo et al.; licensee BioMed Central Ltd. |
format |
Article in Journal/Newspaper |
author |
Waterloo, S Nguyen, T Ahmed, LA Center, JR Morseth, B Nguyen, ND Eisman, JA Søgaard, AJ Emaus, N |
author_facet |
Waterloo, S Nguyen, T Ahmed, LA Center, JR Morseth, B Nguyen, ND Eisman, JA Søgaard, AJ Emaus, N |
author_sort |
Waterloo, S |
title |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_short |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_full |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_fullStr |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_full_unstemmed |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_sort |
important risk factors and attributable risk of vertebral fractures in the population-based tromsø study |
publishDate |
2012 |
url |
http://hdl.handle.net/10453/28801 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMC Musculoskeletal Disorders 10.1186/1471-2474-13-163 BMC Musculoskeletal Disorders, 2012, 13 http://hdl.handle.net/10453/28801 |
_version_ |
1766219374250688512 |