Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data
Background: Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose-response information for this relationship is useful for estimating benefits of reduced mercury exposure. Objectives: We estimated a dose-response relationship betwe...
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ftunivtsydney:oai:opus.lib.uts.edu.au:10453/26012 2023-05-15T16:10:37+02:00 Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data Axelrad, DA Bellinger, DC Ryan, LM Woodruff, TJ 2007-04-01 application/pdf http://hdl.handle.net/10453/26012 unknown Environmental Health Perspectives 10.1289/ehp.9303 Environmental Health Perspectives, 2007, 115 (4), pp. 609 - 615 0091-6765 http://hdl.handle.net/10453/26012 Toxicology Humans Prenatal Exposure Delayed Effects Mercury Environmental Pollutants Endpoint Determination Bayes Theorem Epidemiologic Studies Body Burden Child Development Intelligence Cognition Disorders Motor Skills Disorders Pregnancy Dose-Response Relationship Drug Adult Child Seychelles New Zealand Female Journal Article 2007 ftunivtsydney 2022-03-13T13:20:51Z Background: Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose-response information for this relationship is useful for estimating benefits of reduced mercury exposure. Objectives: We estimated a dose-response relationship between maternal mercury body burden and subsequent childhood decrements in intelligence quotient (IQ), using a Bayesian hierarchical model to integrate data from three epidemiologic studies. Methods: Inputs to the model consist of dose-response coefficients from studies conducted in the Faroe Islands, New Zealand, and the Seychelles Islands. IQ coefficients were available from previous work for the latter two studies, and a coefficient for the Faroe Islands study was estimated from three IQ subtests. Other tests of cognition/achievement were included in the hierarchical model to obtain more accurate estimates of study-to-study and end point-to-end point variability. Results: We find a central estimate of -0.18 IQ points (95% confidence interval, -0.378 to -0.009) for each parts per million increase of maternal hair mercury, similar to the estimates for both the Faroe Islands and Seychelles studies, and lower in magnitude than the estimate for the New Zealand study. Sensitivity analyses produce similar results, with the IQ coefficient central estimate ranging from -0.13 to -0.25. Conclusions: IQ is a useful end point for estimating neurodevelopmental effects, but may not fully represent cognitive deficits associated with mercury exposure, and does not represent deficits related to attention and motor skills. Nevertheless, the integrated IQ coefficient provides a more robust description of the dose-response relationship for prenatal mercury exposure and cognitive functioning than results of any single study. Article in Journal/Newspaper Faroe Islands University of Technology Sydney: OPUS - Open Publications of UTS Scholars Faroe Islands New Zealand |
institution |
Open Polar |
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University of Technology Sydney: OPUS - Open Publications of UTS Scholars |
op_collection_id |
ftunivtsydney |
language |
unknown |
topic |
Toxicology Humans Prenatal Exposure Delayed Effects Mercury Environmental Pollutants Endpoint Determination Bayes Theorem Epidemiologic Studies Body Burden Child Development Intelligence Cognition Disorders Motor Skills Disorders Pregnancy Dose-Response Relationship Drug Adult Child Seychelles New Zealand Female |
spellingShingle |
Toxicology Humans Prenatal Exposure Delayed Effects Mercury Environmental Pollutants Endpoint Determination Bayes Theorem Epidemiologic Studies Body Burden Child Development Intelligence Cognition Disorders Motor Skills Disorders Pregnancy Dose-Response Relationship Drug Adult Child Seychelles New Zealand Female Axelrad, DA Bellinger, DC Ryan, LM Woodruff, TJ Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data |
topic_facet |
Toxicology Humans Prenatal Exposure Delayed Effects Mercury Environmental Pollutants Endpoint Determination Bayes Theorem Epidemiologic Studies Body Burden Child Development Intelligence Cognition Disorders Motor Skills Disorders Pregnancy Dose-Response Relationship Drug Adult Child Seychelles New Zealand Female |
description |
Background: Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose-response information for this relationship is useful for estimating benefits of reduced mercury exposure. Objectives: We estimated a dose-response relationship between maternal mercury body burden and subsequent childhood decrements in intelligence quotient (IQ), using a Bayesian hierarchical model to integrate data from three epidemiologic studies. Methods: Inputs to the model consist of dose-response coefficients from studies conducted in the Faroe Islands, New Zealand, and the Seychelles Islands. IQ coefficients were available from previous work for the latter two studies, and a coefficient for the Faroe Islands study was estimated from three IQ subtests. Other tests of cognition/achievement were included in the hierarchical model to obtain more accurate estimates of study-to-study and end point-to-end point variability. Results: We find a central estimate of -0.18 IQ points (95% confidence interval, -0.378 to -0.009) for each parts per million increase of maternal hair mercury, similar to the estimates for both the Faroe Islands and Seychelles studies, and lower in magnitude than the estimate for the New Zealand study. Sensitivity analyses produce similar results, with the IQ coefficient central estimate ranging from -0.13 to -0.25. Conclusions: IQ is a useful end point for estimating neurodevelopmental effects, but may not fully represent cognitive deficits associated with mercury exposure, and does not represent deficits related to attention and motor skills. Nevertheless, the integrated IQ coefficient provides a more robust description of the dose-response relationship for prenatal mercury exposure and cognitive functioning than results of any single study. |
format |
Article in Journal/Newspaper |
author |
Axelrad, DA Bellinger, DC Ryan, LM Woodruff, TJ |
author_facet |
Axelrad, DA Bellinger, DC Ryan, LM Woodruff, TJ |
author_sort |
Axelrad, DA |
title |
Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data |
title_short |
Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data |
title_full |
Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data |
title_fullStr |
Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data |
title_full_unstemmed |
Dose-response relationship of prenatal mercury exposure and IQ: An integrative analysis of epidemiologic data |
title_sort |
dose-response relationship of prenatal mercury exposure and iq: an integrative analysis of epidemiologic data |
publishDate |
2007 |
url |
http://hdl.handle.net/10453/26012 |
geographic |
Faroe Islands New Zealand |
geographic_facet |
Faroe Islands New Zealand |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_relation |
Environmental Health Perspectives 10.1289/ehp.9303 Environmental Health Perspectives, 2007, 115 (4), pp. 609 - 615 0091-6765 http://hdl.handle.net/10453/26012 |
_version_ |
1765995777981677568 |