Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment
Large mysticete whales represent a unique challenge for chemical risk assessment. Few epidemiological investigations are possible due to the low incidence of adult stranding events. Similarly their often extreme life-history adaptations of prolonged migration and fasting challenge exposure assumptio...
Main Authors: | , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
2011
|
Subjects: | |
Online Access: | http://hdl.handle.net/10453/113162 |
id |
ftunivtsydney:oai:opus.lib.uts.edu.au:10453/113162 |
---|---|
record_format |
openpolar |
spelling |
ftunivtsydney:oai:opus.lib.uts.edu.au:10453/113162 2023-05-15T16:35:53+02:00 Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment Waugh, CA Huston, WM Noad, MJ Bengtson Nash, S 2011-04-01 application/pdf http://hdl.handle.net/10453/113162 unknown Marine Pollution Bulletin 10.1016/j.marpolbul.2011.01.007 Marine Pollution Bulletin, 2011, 62 (4), pp. 758 - 761 0025-326X http://hdl.handle.net/10453/113162 Marine Biology & Hydrobiology Skin Animals Cytochrome P-450 Enzyme System Isoenzymes Biological Markers Water Pollutants Chemical Risk Assessment Environmental Monitoring Female Male Humpback Whale Biomarkers Journal Article 2011 ftunivtsydney 2022-03-13T13:32:40Z Large mysticete whales represent a unique challenge for chemical risk assessment. Few epidemiological investigations are possible due to the low incidence of adult stranding events. Similarly their often extreme life-history adaptations of prolonged migration and fasting challenge exposure assumptions. Molecular biomarkers offer the potential to complement information yielded through tissue chemical analysis, as well as providing evidence of a molecular response to chemical exposure. In this study we confirm the presence of cytochrome P450 reductase (CPR) and cytochrome P450 isoenzyme 1A1 (CYP1A1) in epidermal tissue of southern hemisphere humpback whales (Megaptera novaeangliae). The detection of CYP1A1 in the integument of the humpback whale affords the opportunity for further quantitative non-destructive investigations of enzyme activity as a function of chemical stress. © 2011 Elsevier Ltd. Article in Journal/Newspaper Humpback Whale Megaptera novaeangliae University of Technology Sydney: OPUS - Open Publications of UTS Scholars |
institution |
Open Polar |
collection |
University of Technology Sydney: OPUS - Open Publications of UTS Scholars |
op_collection_id |
ftunivtsydney |
language |
unknown |
topic |
Marine Biology & Hydrobiology Skin Animals Cytochrome P-450 Enzyme System Isoenzymes Biological Markers Water Pollutants Chemical Risk Assessment Environmental Monitoring Female Male Humpback Whale Biomarkers |
spellingShingle |
Marine Biology & Hydrobiology Skin Animals Cytochrome P-450 Enzyme System Isoenzymes Biological Markers Water Pollutants Chemical Risk Assessment Environmental Monitoring Female Male Humpback Whale Biomarkers Waugh, CA Huston, WM Noad, MJ Bengtson Nash, S Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment |
topic_facet |
Marine Biology & Hydrobiology Skin Animals Cytochrome P-450 Enzyme System Isoenzymes Biological Markers Water Pollutants Chemical Risk Assessment Environmental Monitoring Female Male Humpback Whale Biomarkers |
description |
Large mysticete whales represent a unique challenge for chemical risk assessment. Few epidemiological investigations are possible due to the low incidence of adult stranding events. Similarly their often extreme life-history adaptations of prolonged migration and fasting challenge exposure assumptions. Molecular biomarkers offer the potential to complement information yielded through tissue chemical analysis, as well as providing evidence of a molecular response to chemical exposure. In this study we confirm the presence of cytochrome P450 reductase (CPR) and cytochrome P450 isoenzyme 1A1 (CYP1A1) in epidermal tissue of southern hemisphere humpback whales (Megaptera novaeangliae). The detection of CYP1A1 in the integument of the humpback whale affords the opportunity for further quantitative non-destructive investigations of enzyme activity as a function of chemical stress. © 2011 Elsevier Ltd. |
format |
Article in Journal/Newspaper |
author |
Waugh, CA Huston, WM Noad, MJ Bengtson Nash, S |
author_facet |
Waugh, CA Huston, WM Noad, MJ Bengtson Nash, S |
author_sort |
Waugh, CA |
title |
Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment |
title_short |
Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment |
title_full |
Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment |
title_fullStr |
Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment |
title_full_unstemmed |
Cytochrome P450 isozyme protein verified in the skin of southern hemisphere humpback whales (Megaptera novaeangliae): Implications for biochemical biomarker assessment |
title_sort |
cytochrome p450 isozyme protein verified in the skin of southern hemisphere humpback whales (megaptera novaeangliae): implications for biochemical biomarker assessment |
publishDate |
2011 |
url |
http://hdl.handle.net/10453/113162 |
genre |
Humpback Whale Megaptera novaeangliae |
genre_facet |
Humpback Whale Megaptera novaeangliae |
op_relation |
Marine Pollution Bulletin 10.1016/j.marpolbul.2011.01.007 Marine Pollution Bulletin, 2011, 62 (4), pp. 758 - 761 0025-326X http://hdl.handle.net/10453/113162 |
_version_ |
1766026198765273088 |