Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study
Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a...
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UiT Norges arktiske universitet
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ftunivtroemsoe:oai:munin.uit.no:10037/9894 2023-05-15T18:34:13+02:00 Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study Lerstad, Gunhild 2015-10-23 https://hdl.handle.net/10037/9894 eng eng UiT Norges arktiske universitet UiT The Arctic University of Norway https://hdl.handle.net/10037/9894 openAccess Copyright 2015 The Author(s) VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 MED-3910 Master thesis Mastergradsoppgave 2015 ftunivtroemsoe 2021-06-25T17:54:56Z Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) who participated in one or more surveys of the Tromsø study (Tromsø 4; 1994-95, Tromsø 5; 2001-2, and Tromsø 6; 2007-8). All subjects were followed, and incident VTE events were recorded through December 31, 2010. Results: There were 333 validated first VTE events, of which 137 were unprovoked, during a median follow-up of 7.1 years. HbA1c was not associated with future risk of VTE in analysis treating HbA1c as a continuous variable, or in categorized analyses. The risk of VTE increased by 5% per 1 SD (0.7%) increase in HbA1c (multivariable-adjusted HR 1.05; 95% CI 0.97-1.14), and subjects with HbA1c ≥ 6.5% had 27% higher risk compared to those with HbA1c below 5.7% (multivariable-adjusted HR 1.27; 95% CI 0.72-2.26). There was no significant linear trend for increased risk of VTE across categories of HbA1c (p=0.27). Conclusions: Serum levels of HbA1c were not associated with future risk of VTE in multivariable analysis. Our findings suggest that hyperglycemia does not play an important role in the pathogenesis of VTE. Master Thesis Tromsø University of Tromsø: Munin Open Research Archive Tromsø |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 MED-3910 |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 MED-3910 Lerstad, Gunhild Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 MED-3910 |
description |
Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) who participated in one or more surveys of the Tromsø study (Tromsø 4; 1994-95, Tromsø 5; 2001-2, and Tromsø 6; 2007-8). All subjects were followed, and incident VTE events were recorded through December 31, 2010. Results: There were 333 validated first VTE events, of which 137 were unprovoked, during a median follow-up of 7.1 years. HbA1c was not associated with future risk of VTE in analysis treating HbA1c as a continuous variable, or in categorized analyses. The risk of VTE increased by 5% per 1 SD (0.7%) increase in HbA1c (multivariable-adjusted HR 1.05; 95% CI 0.97-1.14), and subjects with HbA1c ≥ 6.5% had 27% higher risk compared to those with HbA1c below 5.7% (multivariable-adjusted HR 1.27; 95% CI 0.72-2.26). There was no significant linear trend for increased risk of VTE across categories of HbA1c (p=0.27). Conclusions: Serum levels of HbA1c were not associated with future risk of VTE in multivariable analysis. Our findings suggest that hyperglycemia does not play an important role in the pathogenesis of VTE. |
format |
Master Thesis |
author |
Lerstad, Gunhild |
author_facet |
Lerstad, Gunhild |
author_sort |
Lerstad, Gunhild |
title |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study |
title_short |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study |
title_full |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study |
title_fullStr |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study |
title_full_unstemmed |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism -The Tromsø Study |
title_sort |
hyperglycemia, assessed by hba1c, and future risk of venous thromboembolism -the tromsø study |
publisher |
UiT Norges arktiske universitet |
publishDate |
2015 |
url |
https://hdl.handle.net/10037/9894 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://hdl.handle.net/10037/9894 |
op_rights |
openAccess Copyright 2015 The Author(s) |
_version_ |
1766218874855882752 |