COPD in primary lung cancer patients: prevalence and mortality
Published version, also available at http://dx.doi.org/10.2147/COPD.S101183 . Creative Commons Attribution - Non Commercial (unported, v3.0) License Background: Previous studies have relied on international spirometry criteria to diagnose COPD in patients with lung cancer without considering the eff...
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ftunivtroemsoe:oai:munin.uit.no:10037/9082 2023-05-15T17:39:25+02:00 COPD in primary lung cancer patients: prevalence and mortality Ytterstad, Elinor Moe, Per Christian Hjalmarsen, Audhild 2016-03-23 https://hdl.handle.net/10037/9082 eng eng Dove medical Press The International Journal of Chronic Obstructive Pulmonary Disease 2016, 11(1):625-636 FRIDAID 1347012 dx.doi.org/10.2147/COPD.S101183 1178-2005 https://hdl.handle.net/10037/9082 URN:NBN:no-uit_munin_8658 openAccess VDP::Medical disciplines: 700 Journal article Peer reviewed Tidsskriftartikkel 2016 ftunivtroemsoe https://doi.org/10.2147/COPD.S101183 2021-06-25T17:54:42Z Published version, also available at http://dx.doi.org/10.2147/COPD.S101183 . Creative Commons Attribution - Non Commercial (unported, v3.0) License Background: Previous studies have relied on international spirometry criteria to diagnose COPD in patients with lung cancer without considering the effect lung cancer might have on spirometric results. The aim of this study was to examine the prevalence of COPD and emphysema at the time of primary lung cancer diagnosis and to examine factors associated with survival. Materials and methods: Medical records, pulmonary function tests, and computed tomography scans were used to determine the presence of COPD and emphysema in patients diagnosed with primary lung cancer at the University Hospital of North Norway in 2008–2010. Results: Among the 174 lung cancer patients, 69% had COPD or emphysema (39% with COPD, 59% with emphysema; male:female ratio 101:73). Neither COPD nor emphysema were significantly associated with lung cancer mortality, whereas patients with non-small-cell lung cancer other than adenocarcinoma and squamous cell carcinoma had a risk of lung cancer mortality that was more than four times higher than that of patients with small-cell lung cancer (hazard ratio [HR] 4.19, 95% confidence interval [CI] 1.56–11.25). Females had a lower risk of lung cancer mortality than males (HR 0.63, 95% CI 0.42–0.94), and patients aged ≥75 years had a risk that was twice that of patients aged <75 years (HR 2.48, 95% CI 1.59–3.87). Low partial arterial oxygen pressure (4.0–8.4 kPa) increased the risk of lung cancer mortality (HR 2.26, 95% CI 1.29–3.96). So did low partial arterial carbon dioxide pressure (3.0–4.9 kPa) among stage IV lung cancer patients (HR 2.23, 95% CI 1.29–3.85). Several patients with respiratory failure had previously been diagnosed with COPD. Conclusion: The observed prevalence of COPD was lower than that in previous studies. Neither COPD nor emphysema were significantly associated with lung cancer mortality. Article in Journal/Newspaper North Norway University of Tromsø: Munin Open Research Archive Norway International Journal of Chronic Obstructive Pulmonary Disease 625 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700 |
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VDP::Medical disciplines: 700 Ytterstad, Elinor Moe, Per Christian Hjalmarsen, Audhild COPD in primary lung cancer patients: prevalence and mortality |
topic_facet |
VDP::Medical disciplines: 700 |
description |
Published version, also available at http://dx.doi.org/10.2147/COPD.S101183 . Creative Commons Attribution - Non Commercial (unported, v3.0) License Background: Previous studies have relied on international spirometry criteria to diagnose COPD in patients with lung cancer without considering the effect lung cancer might have on spirometric results. The aim of this study was to examine the prevalence of COPD and emphysema at the time of primary lung cancer diagnosis and to examine factors associated with survival. Materials and methods: Medical records, pulmonary function tests, and computed tomography scans were used to determine the presence of COPD and emphysema in patients diagnosed with primary lung cancer at the University Hospital of North Norway in 2008–2010. Results: Among the 174 lung cancer patients, 69% had COPD or emphysema (39% with COPD, 59% with emphysema; male:female ratio 101:73). Neither COPD nor emphysema were significantly associated with lung cancer mortality, whereas patients with non-small-cell lung cancer other than adenocarcinoma and squamous cell carcinoma had a risk of lung cancer mortality that was more than four times higher than that of patients with small-cell lung cancer (hazard ratio [HR] 4.19, 95% confidence interval [CI] 1.56–11.25). Females had a lower risk of lung cancer mortality than males (HR 0.63, 95% CI 0.42–0.94), and patients aged ≥75 years had a risk that was twice that of patients aged <75 years (HR 2.48, 95% CI 1.59–3.87). Low partial arterial oxygen pressure (4.0–8.4 kPa) increased the risk of lung cancer mortality (HR 2.26, 95% CI 1.29–3.96). So did low partial arterial carbon dioxide pressure (3.0–4.9 kPa) among stage IV lung cancer patients (HR 2.23, 95% CI 1.29–3.85). Several patients with respiratory failure had previously been diagnosed with COPD. Conclusion: The observed prevalence of COPD was lower than that in previous studies. Neither COPD nor emphysema were significantly associated with lung cancer mortality. |
format |
Article in Journal/Newspaper |
author |
Ytterstad, Elinor Moe, Per Christian Hjalmarsen, Audhild |
author_facet |
Ytterstad, Elinor Moe, Per Christian Hjalmarsen, Audhild |
author_sort |
Ytterstad, Elinor |
title |
COPD in primary lung cancer patients: prevalence and mortality |
title_short |
COPD in primary lung cancer patients: prevalence and mortality |
title_full |
COPD in primary lung cancer patients: prevalence and mortality |
title_fullStr |
COPD in primary lung cancer patients: prevalence and mortality |
title_full_unstemmed |
COPD in primary lung cancer patients: prevalence and mortality |
title_sort |
copd in primary lung cancer patients: prevalence and mortality |
publisher |
Dove medical Press |
publishDate |
2016 |
url |
https://hdl.handle.net/10037/9082 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
North Norway |
genre_facet |
North Norway |
op_relation |
The International Journal of Chronic Obstructive Pulmonary Disease 2016, 11(1):625-636 FRIDAID 1347012 dx.doi.org/10.2147/COPD.S101183 1178-2005 https://hdl.handle.net/10037/9082 URN:NBN:no-uit_munin_8658 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.2147/COPD.S101183 |
container_title |
International Journal of Chronic Obstructive Pulmonary Disease |
container_start_page |
625 |
_version_ |
1766140177588158464 |