Red cell distribution width is associated with future risk of incident stroke. The Tromsø study
Accepted manuscript version. This article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of “Red cell distribution width is associated with future risk of incident stroke. The Tromsø study" is available online...
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Online Access: | https://hdl.handle.net/10037/9055 https://doi.org/10.1160/TH15-03-0234 |
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ftunivtroemsoe:oai:munin.uit.no:10037/9055 2023-05-15T18:34:24+02:00 Red cell distribution width is associated with future risk of incident stroke. The Tromsø study Lappegård, Jostein Ellingsen, Trygve Skjelbakken, Tove Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Brox, Jan Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2015-08-20 https://hdl.handle.net/10037/9055 https://doi.org/10.1160/TH15-03-0234 eng eng Schattauer The published version of this article is part of Lappegård, J. (2018). Red Cell Distribution Width (RDW) and future risk of arterial cardiovascular diseases. Doctoral thesis. http://hdl.handle.net/10037/12988. Stiftelsen Kristian Gerhard Jebsen: SKGJ-MED-012 Thrombosis and Haemostasis 2015 FRIDAID 1288509 doi:10.1160/TH15-03-0234 0340-6245 https://hdl.handle.net/10037/9055 URN:NBN:no-uit_munin_8645 openAccess VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750 Epidemiological studies stroke risk factors Journal article Tidsskriftartikkel Peer reviewed 2015 ftunivtroemsoe https://doi.org/10.1160/TH15-03-0234 2021-06-25T17:54:34Z Accepted manuscript version. This article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of “Red cell distribution width is associated with future risk of incident stroke. The Tromsø study" is available online at http://doi.org/10.1160/TH15-03-0234 . Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth survey of the Tromsø Study, conducted in 1994/95. Incident stroke was registered from inclusion until December 31, 2010. Cox regression models were used to calculate hazard ratios (HR) with 95 % confidence intervals (95 % CI) for stroke, adjusted for age, sex, body mass index, smoking, haemoglobin level, white blood cell count, thrombocyte count, hypertension, total cholesterol, triglycerides, self-reported diabetes, and red blood cell count. During a median follow-up of 15.8 years, 1152 participants experienced a first-ever stroke. A 1 % increment in RDW yielded a 13 % higher risk of stroke (multivariable HR: 1.13, 95 % CI: 1.07–1.20). Subjects with RDW in the highest quintile compared to the lowest had a 37 % higher risk of stroke in multivariable analysis (HR: 1.37, 95 % CI: 1.11–1.69). Subjects with RDW above the 95-percentile had 55 % higher risk of stroke compared to those in the lowest quintile (HR: 1.55, 95 % CI: 1.16–2.06). All risk estimates remained unchanged after exclusion of subjects with anaemia (n=1102). RDW was not associated with increased risk of death within one year or during the entire follow-up after an incident stroke. RDW is associated with incident stroke in a general population, independent of anaemia and traditional atherosclerotic risk factors. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Thrombosis and Haemostasis 115 01 126 134 |
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Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750 Epidemiological studies stroke risk factors |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750 Epidemiological studies stroke risk factors Lappegård, Jostein Ellingsen, Trygve Skjelbakken, Tove Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Brox, Jan Brækkan, Sigrid Kufaas Hansen, John-Bjarne Red cell distribution width is associated with future risk of incident stroke. The Tromsø study |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750 Epidemiological studies stroke risk factors |
description |
Accepted manuscript version. This article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of “Red cell distribution width is associated with future risk of incident stroke. The Tromsø study" is available online at http://doi.org/10.1160/TH15-03-0234 . Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth survey of the Tromsø Study, conducted in 1994/95. Incident stroke was registered from inclusion until December 31, 2010. Cox regression models were used to calculate hazard ratios (HR) with 95 % confidence intervals (95 % CI) for stroke, adjusted for age, sex, body mass index, smoking, haemoglobin level, white blood cell count, thrombocyte count, hypertension, total cholesterol, triglycerides, self-reported diabetes, and red blood cell count. During a median follow-up of 15.8 years, 1152 participants experienced a first-ever stroke. A 1 % increment in RDW yielded a 13 % higher risk of stroke (multivariable HR: 1.13, 95 % CI: 1.07–1.20). Subjects with RDW in the highest quintile compared to the lowest had a 37 % higher risk of stroke in multivariable analysis (HR: 1.37, 95 % CI: 1.11–1.69). Subjects with RDW above the 95-percentile had 55 % higher risk of stroke compared to those in the lowest quintile (HR: 1.55, 95 % CI: 1.16–2.06). All risk estimates remained unchanged after exclusion of subjects with anaemia (n=1102). RDW was not associated with increased risk of death within one year or during the entire follow-up after an incident stroke. RDW is associated with incident stroke in a general population, independent of anaemia and traditional atherosclerotic risk factors. |
format |
Article in Journal/Newspaper |
author |
Lappegård, Jostein Ellingsen, Trygve Skjelbakken, Tove Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Brox, Jan Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Lappegård, Jostein Ellingsen, Trygve Skjelbakken, Tove Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Brox, Jan Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Lappegård, Jostein |
title |
Red cell distribution width is associated with future risk of incident stroke. The Tromsø study |
title_short |
Red cell distribution width is associated with future risk of incident stroke. The Tromsø study |
title_full |
Red cell distribution width is associated with future risk of incident stroke. The Tromsø study |
title_fullStr |
Red cell distribution width is associated with future risk of incident stroke. The Tromsø study |
title_full_unstemmed |
Red cell distribution width is associated with future risk of incident stroke. The Tromsø study |
title_sort |
red cell distribution width is associated with future risk of incident stroke. the tromsø study |
publisher |
Schattauer |
publishDate |
2015 |
url |
https://hdl.handle.net/10037/9055 https://doi.org/10.1160/TH15-03-0234 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
The published version of this article is part of Lappegård, J. (2018). Red Cell Distribution Width (RDW) and future risk of arterial cardiovascular diseases. Doctoral thesis. http://hdl.handle.net/10037/12988. Stiftelsen Kristian Gerhard Jebsen: SKGJ-MED-012 Thrombosis and Haemostasis 2015 FRIDAID 1288509 doi:10.1160/TH15-03-0234 0340-6245 https://hdl.handle.net/10037/9055 URN:NBN:no-uit_munin_8645 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1160/TH15-03-0234 |
container_title |
Thrombosis and Haemostasis |
container_volume |
115 |
container_issue |
01 |
container_start_page |
126 |
op_container_end_page |
134 |
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1766219119546335232 |