Red cell distribution width and carotid atherosclerosis progression: The Tromsø study
Accepted manuscript version. This article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of "Red cell distribution width and carotid atherosclerosis progression: The Tromsø study" is available online at:...
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Online Access: | https://hdl.handle.net/10037/9054 https://doi.org/10.1160/TH14-07-0606 |
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ftunivtroemsoe:oai:munin.uit.no:10037/9054 2023-05-15T18:34:21+02:00 Red cell distribution width and carotid atherosclerosis progression: The Tromsø study Lappegård, Jostein Ellingsen, Trygve Vik, Anders Skjelbakken, Tove Brox, Jan Mathiesen, Ellisiv B. Johnsen, Stein Harald Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2015-01-29 https://hdl.handle.net/10037/9054 https://doi.org/10.1160/TH14-07-0606 eng eng Schattauer Thrombosis and Haemostasis 2015, 113(3):649-654 FRIDAID 1193782 doi:10.1160/TH14-07-0606 0340-6245 https://hdl.handle.net/10037/9054 URN:NBN:no-uit_munin_8643 openAccess Atherosclerosis Cardiovascular Disease Epidemiology cohort studies erythrocyte indices VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 Journal article Tidsskriftartikkel Peer reviewed 2015 ftunivtroemsoe https://doi.org/10.1160/TH14-07-0606 2021-06-25T17:54:34Z Accepted manuscript version. This article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of "Red cell distribution width and carotid atherosclerosis progression: The Tromsø study" is available online at: http://doi.org/10.1160/TH14-07-0606 . Red cell distribution width (RDW), a measure of the size variability of circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with progression of atherosclerotic plaques in subjects recruited from the general population. Baseline characteristics, including RDW, were collected from 4677 participants in the fourth survey of the Tromsø Study conducted in 1994/95. Prevalence of carotid plaques and total plaque area (TPA) were assessed by ultrasonographic imaging at baseline and after seven years of follow-up. Generalised linear models were used to analyse change in TPA across tertiles of RDW. Change in TPA was significantly higher across tertiles of RDW in crude analysis and in multivariable analysis adjusted for cardiovascular risk factors. The mean change in TPA increased from 5.6 mm² (4.9–6.4) in tertile 1 (RDW ≤ 12.6 %) to 6.7 mm² (5.9–7.6) in tertile 3 (RDW ≥ 13.3) in multivariable analysis adjusted for body mass index, total cholesterol, HDL cholesterol, systolic blood pressure, self-reported diabetes, smoking status, platelet count, white blood cell count, and hs-CRP levels (p for trend 0.003). A 1 % increase in RDW was associated with 0.6 mm² (0.1–1.2) increase in TPA in multivariable analysis (p=0.03). RDW was associated with progression of atherosclerosis after adjustments for traditional atherosclerotic risk factors. Our findings suggest that the link between RDW and cardiovascular morbidity and mortality may be explained by atherosclerosis. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Thrombosis and Haemostasis 113 03 649 654 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
Atherosclerosis Cardiovascular Disease Epidemiology cohort studies erythrocyte indices VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 |
spellingShingle |
Atherosclerosis Cardiovascular Disease Epidemiology cohort studies erythrocyte indices VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 Lappegård, Jostein Ellingsen, Trygve Vik, Anders Skjelbakken, Tove Brox, Jan Mathiesen, Ellisiv B. Johnsen, Stein Harald Brækkan, Sigrid Kufaas Hansen, John-Bjarne Red cell distribution width and carotid atherosclerosis progression: The Tromsø study |
topic_facet |
Atherosclerosis Cardiovascular Disease Epidemiology cohort studies erythrocyte indices VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 |
description |
Accepted manuscript version. This article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of "Red cell distribution width and carotid atherosclerosis progression: The Tromsø study" is available online at: http://doi.org/10.1160/TH14-07-0606 . Red cell distribution width (RDW), a measure of the size variability of circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with progression of atherosclerotic plaques in subjects recruited from the general population. Baseline characteristics, including RDW, were collected from 4677 participants in the fourth survey of the Tromsø Study conducted in 1994/95. Prevalence of carotid plaques and total plaque area (TPA) were assessed by ultrasonographic imaging at baseline and after seven years of follow-up. Generalised linear models were used to analyse change in TPA across tertiles of RDW. Change in TPA was significantly higher across tertiles of RDW in crude analysis and in multivariable analysis adjusted for cardiovascular risk factors. The mean change in TPA increased from 5.6 mm² (4.9–6.4) in tertile 1 (RDW ≤ 12.6 %) to 6.7 mm² (5.9–7.6) in tertile 3 (RDW ≥ 13.3) in multivariable analysis adjusted for body mass index, total cholesterol, HDL cholesterol, systolic blood pressure, self-reported diabetes, smoking status, platelet count, white blood cell count, and hs-CRP levels (p for trend 0.003). A 1 % increase in RDW was associated with 0.6 mm² (0.1–1.2) increase in TPA in multivariable analysis (p=0.03). RDW was associated with progression of atherosclerosis after adjustments for traditional atherosclerotic risk factors. Our findings suggest that the link between RDW and cardiovascular morbidity and mortality may be explained by atherosclerosis. |
format |
Article in Journal/Newspaper |
author |
Lappegård, Jostein Ellingsen, Trygve Vik, Anders Skjelbakken, Tove Brox, Jan Mathiesen, Ellisiv B. Johnsen, Stein Harald Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Lappegård, Jostein Ellingsen, Trygve Vik, Anders Skjelbakken, Tove Brox, Jan Mathiesen, Ellisiv B. Johnsen, Stein Harald Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Lappegård, Jostein |
title |
Red cell distribution width and carotid atherosclerosis progression: The Tromsø study |
title_short |
Red cell distribution width and carotid atherosclerosis progression: The Tromsø study |
title_full |
Red cell distribution width and carotid atherosclerosis progression: The Tromsø study |
title_fullStr |
Red cell distribution width and carotid atherosclerosis progression: The Tromsø study |
title_full_unstemmed |
Red cell distribution width and carotid atherosclerosis progression: The Tromsø study |
title_sort |
red cell distribution width and carotid atherosclerosis progression: the tromsø study |
publisher |
Schattauer |
publishDate |
2015 |
url |
https://hdl.handle.net/10037/9054 https://doi.org/10.1160/TH14-07-0606 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Thrombosis and Haemostasis 2015, 113(3):649-654 FRIDAID 1193782 doi:10.1160/TH14-07-0606 0340-6245 https://hdl.handle.net/10037/9054 URN:NBN:no-uit_munin_8643 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1160/TH14-07-0606 |
container_title |
Thrombosis and Haemostasis |
container_volume |
113 |
container_issue |
03 |
container_start_page |
649 |
op_container_end_page |
654 |
_version_ |
1766219055396552704 |