Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention
Published version. Source at http://doi.org/10.1007/s00005-015-0371-9 . Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a relatively rare condition (1/1000–1/2000) that was granted orphan status by the European Medicines Agency in 2011. Clinical consequences of FNAIT, however, may be severe. A...
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ftunivtroemsoe:oai:munin.uit.no:10037/8935 2023-05-15T18:49:26+02:00 Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention Brojer, Eva Husebekk, Anne Debska, Marzena Uhrynowska, Malgorozata Guz, Katarzyna Orzinska, Agnieszka Debski, Romuald Maslanka, Krystyna 2015-11-12 https://hdl.handle.net/10037/8935 https://doi.org/10.1007/s00005-015-0371-9 eng eng Springer Archivum Immunologiae et Therapiae Experimentalis 2015 FRIDAID 1326206 doi:10.1007/s00005-015-0371-9 0004-069X https://hdl.handle.net/10037/8935 URN:NBN:no-uit_munin_8484 openAccess Human platelet alloantigens Pregnancy Fetal/neonatal alloimmune thrombocytopenia Therapeutic intervention VDP::Medisinske Fag: 700::Helsefag: 800 Journal article Tidsskriftartikkel Peer reviewed 2015 ftunivtroemsoe https://doi.org/10.1007/s00005-015-0371-9 2021-06-25T17:54:35Z Published version. Source at http://doi.org/10.1007/s00005-015-0371-9 . Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a relatively rare condition (1/1000–1/2000) that was granted orphan status by the European Medicines Agency in 2011. Clinical consequences of FNAIT, however, may be severe. A thrombocytopenic fetus or new-born is at risk of intracranial hemorrhage that may result in lifelong disability or death. Preventing such bleeding is thus vital and requires a solution. Anti-HPA1a antibodies are the most frequent cause of FNAIT in Caucasians. Its pathogenesis is similar to hemolytic disease of the newborn (HDN) due to anti-RhD antibodies, but is characterized by platelet destruction and is more often observed in the first pregnancy. In 75 % of these women, alloimmunization by HPA-1a antigens, however, occurs at delivery, which enables development of antibody-mediated immune suppression to prevent maternal immunization. As for HDN, the recurrence rate of FNAIT is high. For advancing diagnostic efforts and treatment, it is thereby crucial to understand the pathogenesis of FNAIT, including cellular immunity involvement. This review presents the current knowledge on FNAIT. Also described is a program for HPA-1a screening in identifying HPA-1a negative pregnant women at risk of immunization. This program is now performed at the Institute of Hematology and Transfusion Medicine in cooperation with the Department of Obstetrics and Gynecology of the Medical Centre of Postgraduate Education in Warsaw as well as the UiT The Arctic University of Norway. Article in Journal/Newspaper Arctic University of Norway UiT The Arctic University of Norway University of Tromsø: Munin Open Research Archive Arctic Norway Archivum Immunologiae et Therapiae Experimentalis 64 4 279 290 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
Human platelet alloantigens Pregnancy Fetal/neonatal alloimmune thrombocytopenia Therapeutic intervention VDP::Medisinske Fag: 700::Helsefag: 800 |
spellingShingle |
Human platelet alloantigens Pregnancy Fetal/neonatal alloimmune thrombocytopenia Therapeutic intervention VDP::Medisinske Fag: 700::Helsefag: 800 Brojer, Eva Husebekk, Anne Debska, Marzena Uhrynowska, Malgorozata Guz, Katarzyna Orzinska, Agnieszka Debski, Romuald Maslanka, Krystyna Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
topic_facet |
Human platelet alloantigens Pregnancy Fetal/neonatal alloimmune thrombocytopenia Therapeutic intervention VDP::Medisinske Fag: 700::Helsefag: 800 |
description |
Published version. Source at http://doi.org/10.1007/s00005-015-0371-9 . Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a relatively rare condition (1/1000–1/2000) that was granted orphan status by the European Medicines Agency in 2011. Clinical consequences of FNAIT, however, may be severe. A thrombocytopenic fetus or new-born is at risk of intracranial hemorrhage that may result in lifelong disability or death. Preventing such bleeding is thus vital and requires a solution. Anti-HPA1a antibodies are the most frequent cause of FNAIT in Caucasians. Its pathogenesis is similar to hemolytic disease of the newborn (HDN) due to anti-RhD antibodies, but is characterized by platelet destruction and is more often observed in the first pregnancy. In 75 % of these women, alloimmunization by HPA-1a antigens, however, occurs at delivery, which enables development of antibody-mediated immune suppression to prevent maternal immunization. As for HDN, the recurrence rate of FNAIT is high. For advancing diagnostic efforts and treatment, it is thereby crucial to understand the pathogenesis of FNAIT, including cellular immunity involvement. This review presents the current knowledge on FNAIT. Also described is a program for HPA-1a screening in identifying HPA-1a negative pregnant women at risk of immunization. This program is now performed at the Institute of Hematology and Transfusion Medicine in cooperation with the Department of Obstetrics and Gynecology of the Medical Centre of Postgraduate Education in Warsaw as well as the UiT The Arctic University of Norway. |
format |
Article in Journal/Newspaper |
author |
Brojer, Eva Husebekk, Anne Debska, Marzena Uhrynowska, Malgorozata Guz, Katarzyna Orzinska, Agnieszka Debski, Romuald Maslanka, Krystyna |
author_facet |
Brojer, Eva Husebekk, Anne Debska, Marzena Uhrynowska, Malgorozata Guz, Katarzyna Orzinska, Agnieszka Debski, Romuald Maslanka, Krystyna |
author_sort |
Brojer, Eva |
title |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_short |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_full |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_fullStr |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_full_unstemmed |
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention |
title_sort |
fetal/neonatal alloimmune thrombocytopenia: pathogenesis, diagnostics and prevention |
publisher |
Springer |
publishDate |
2015 |
url |
https://hdl.handle.net/10037/8935 https://doi.org/10.1007/s00005-015-0371-9 |
geographic |
Arctic Norway |
geographic_facet |
Arctic Norway |
genre |
Arctic University of Norway UiT The Arctic University of Norway |
genre_facet |
Arctic University of Norway UiT The Arctic University of Norway |
op_relation |
Archivum Immunologiae et Therapiae Experimentalis 2015 FRIDAID 1326206 doi:10.1007/s00005-015-0371-9 0004-069X https://hdl.handle.net/10037/8935 URN:NBN:no-uit_munin_8484 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1007/s00005-015-0371-9 |
container_title |
Archivum Immunologiae et Therapiae Experimentalis |
container_volume |
64 |
container_issue |
4 |
container_start_page |
279 |
op_container_end_page |
290 |
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1766243031417094144 |