Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort
This article was published in the following Dove Press journal: Clinical Epidemiology and available at http://dx.doi.org/10.2147/CLEP.S84279 Background: Although venous thromboembolism (VTE) is a known common complication in cancer patients, there is limited knowledge on patient-related and cancer-s...
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Online Access: | https://hdl.handle.net/10037/8923 https://doi.org/10.2147/CLEP.S84279 |
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ftunivtroemsoe:oai:munin.uit.no:10037/8923 2023-05-15T18:34:54+02:00 Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort Jensvoll, Hilde Severinsen, Marianne T. Hammerstrøm, Jens Brækkan, Sigrid Kufaas Kristensen, Søren R. Cannegieter, Suzanne C. Blix, Kristine Tjønneland, Anne Rosendaal, Frits Richard Dziewiecka, Olga Overvad, Kim Næss, Inger Anne Hansen, John-Bjarne 2015-09-16 https://hdl.handle.net/10037/8923 https://doi.org/10.2147/CLEP.S84279 eng eng Dove Medical Press Clinical Epidemiology 2015, 7:401-410 FRIDAID 1285529 doi:10.2147/CLEP.S84279 1179-1349 https://hdl.handle.net/10037/8923 URN:NBN:no-uit_munin_8492 openAccess VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750 venous thromboembolism incidence rates person-years pulmonary embolism population-based cohort prospective cancer Journal article Tidsskriftartikkel Peer reviewed 2015 ftunivtroemsoe https://doi.org/10.2147/CLEP.S84279 2021-06-25T17:54:39Z This article was published in the following Dove Press journal: Clinical Epidemiology and available at http://dx.doi.org/10.2147/CLEP.S84279 Background: Although venous thromboembolism (VTE) is a known common complication in cancer patients, there is limited knowledge on patient-related and cancer-specific risk factors in the general population. The Scandinavian Thrombosis and Cancer (STAC) Cohort was established by merging individual data from three large Scandinavian cohorts (The Tromsø Study, the second Nord-Trøndelag Health Study, and the Danish Diet, Cancer and Health Study). Here, we present the profile of the STAC cohort and provide age-specific incidence rates of VTE and cancer. Methods: The STAC cohort includes 144,952 subjects aged 19–101 years without previous VTE or cancer. Baseline information collected in 1993–1997 included physical examination, self-administered questionnaires, and blood samples. Validated VTE events and cancer diagnoses were registered up to 2007–2012. Results: There were 2,444 VTE events (1.4 per 1,000 person-years [PY]) during follow-up, and the incidence increased exponentially from 0.3 per 1,000 PY in subjects aged 20–29 years to 6.4 per 1,000 PY in subjects aged 80+. Overall, 51% of the VTE events were provoked, and cancer was the most common provoking factor (19%), followed by immobilization and surgery (both 15%). In total, 19,757 subjects developed cancer during follow-up (9.8 per 1,000 PY), and the 5-year age-specific incidence rates of cancer were coherent with corresponding rates from the Norwegian Cancer Registry. Conclusion: The STAC cohort will provide a unique opportunity to explore the epidemiology and impact of genetic and environmental patient-related and cancer-specific risk factors for VTE in the general population. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Clinical Epidemiology 401 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750 venous thromboembolism incidence rates person-years pulmonary embolism population-based cohort prospective cancer |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750 venous thromboembolism incidence rates person-years pulmonary embolism population-based cohort prospective cancer Jensvoll, Hilde Severinsen, Marianne T. Hammerstrøm, Jens Brækkan, Sigrid Kufaas Kristensen, Søren R. Cannegieter, Suzanne C. Blix, Kristine Tjønneland, Anne Rosendaal, Frits Richard Dziewiecka, Olga Overvad, Kim Næss, Inger Anne Hansen, John-Bjarne Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750 venous thromboembolism incidence rates person-years pulmonary embolism population-based cohort prospective cancer |
description |
This article was published in the following Dove Press journal: Clinical Epidemiology and available at http://dx.doi.org/10.2147/CLEP.S84279 Background: Although venous thromboembolism (VTE) is a known common complication in cancer patients, there is limited knowledge on patient-related and cancer-specific risk factors in the general population. The Scandinavian Thrombosis and Cancer (STAC) Cohort was established by merging individual data from three large Scandinavian cohorts (The Tromsø Study, the second Nord-Trøndelag Health Study, and the Danish Diet, Cancer and Health Study). Here, we present the profile of the STAC cohort and provide age-specific incidence rates of VTE and cancer. Methods: The STAC cohort includes 144,952 subjects aged 19–101 years without previous VTE or cancer. Baseline information collected in 1993–1997 included physical examination, self-administered questionnaires, and blood samples. Validated VTE events and cancer diagnoses were registered up to 2007–2012. Results: There were 2,444 VTE events (1.4 per 1,000 person-years [PY]) during follow-up, and the incidence increased exponentially from 0.3 per 1,000 PY in subjects aged 20–29 years to 6.4 per 1,000 PY in subjects aged 80+. Overall, 51% of the VTE events were provoked, and cancer was the most common provoking factor (19%), followed by immobilization and surgery (both 15%). In total, 19,757 subjects developed cancer during follow-up (9.8 per 1,000 PY), and the 5-year age-specific incidence rates of cancer were coherent with corresponding rates from the Norwegian Cancer Registry. Conclusion: The STAC cohort will provide a unique opportunity to explore the epidemiology and impact of genetic and environmental patient-related and cancer-specific risk factors for VTE in the general population. |
format |
Article in Journal/Newspaper |
author |
Jensvoll, Hilde Severinsen, Marianne T. Hammerstrøm, Jens Brækkan, Sigrid Kufaas Kristensen, Søren R. Cannegieter, Suzanne C. Blix, Kristine Tjønneland, Anne Rosendaal, Frits Richard Dziewiecka, Olga Overvad, Kim Næss, Inger Anne Hansen, John-Bjarne |
author_facet |
Jensvoll, Hilde Severinsen, Marianne T. Hammerstrøm, Jens Brækkan, Sigrid Kufaas Kristensen, Søren R. Cannegieter, Suzanne C. Blix, Kristine Tjønneland, Anne Rosendaal, Frits Richard Dziewiecka, Olga Overvad, Kim Næss, Inger Anne Hansen, John-Bjarne |
author_sort |
Jensvoll, Hilde |
title |
Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort |
title_short |
Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort |
title_full |
Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort |
title_fullStr |
Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort |
title_full_unstemmed |
Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort |
title_sort |
existing data sources in clinical epidemiology: the scandinavian thrombosis and cancer cohort |
publisher |
Dove Medical Press |
publishDate |
2015 |
url |
https://hdl.handle.net/10037/8923 https://doi.org/10.2147/CLEP.S84279 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Clinical Epidemiology 2015, 7:401-410 FRIDAID 1285529 doi:10.2147/CLEP.S84279 1179-1349 https://hdl.handle.net/10037/8923 URN:NBN:no-uit_munin_8492 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.2147/CLEP.S84279 |
container_title |
Clinical Epidemiology |
container_start_page |
401 |
_version_ |
1766219903751159808 |