Low oxygen saturation and mortality in an adult cohort; the Tromsø Study
Published version, also available at http://dx.doi.org/10.1186/s12890-015-0003-5 Background: Oxygen saturation has been shown in risk score models to predict mortality in emergency medicine. The aim of this study was to determine whether low oxygen saturation measured by a single-point measurement b...
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ftunivtroemsoe:oai:munin.uit.no:10037/8876 2023-05-15T18:34:24+02:00 Low oxygen saturation and mortality in an adult cohort; the Tromsø Study Vold, Monica Linea Aasebø, Ulf Wilsgaard, Tom Melbye, Hasse 2015-02-12 https://hdl.handle.net/10037/8876 https://doi.org/10.1186/s12890-015-0003-5 eng eng BioMed Central BMC Pulmonary Medicine (2015) 15:9 FRIDAID 1237978 doi:10.1186/s12890-015-0003-5 1471-2466 https://hdl.handle.net/10037/8876 URN:NBN:no-uit_munin_8459 openAccess VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777 Journal article Tidsskriftartikkel Peer reviewed 2015 ftunivtroemsoe https://doi.org/10.1186/s12890-015-0003-5 2021-06-25T17:54:39Z Published version, also available at http://dx.doi.org/10.1186/s12890-015-0003-5 Background: Oxygen saturation has been shown in risk score models to predict mortality in emergency medicine. The aim of this study was to determine whether low oxygen saturation measured by a single-point measurement by pulse oximetry (SpO2) is associated with increased mortality in the general adult population. Methods: Pulse oximetry was performed in 5,152 participants in a cross-sectional survey in Tromsø, Norway, in 2001–2002 (“Tromsø 5”). Ten-year follow-up data for all-cause mortality and cause of death were obtained from the National Population and the Cause of Death Registries, respectively. Cause of death was grouped into four categories: cardiovascular disease, cancer except lung cancer, pulmonary disease, and others. SpO2 categories were assessed as predictors for all-cause mortality and death using Cox proportional-hazards regression models after correcting for age, sex, smoking history, body mass index (BMI), C-reactive protein level, self-reported diseases, respiratory symptoms, and spirometry results. Results: The mean age was 65.8 years, and 56% were women. During the follow-up, 1,046 (20.3%) participants died. The age- and sex-adjusted hazard ratios (HRs) (95% confidence intervals) for all-cause mortality were 1.99 (1.33–2.96) for SpO2 ≤ 92% and 1.36 (1.15–1.60) for SpO2 93–95%, compared with SpO2 ≥ 96%. In the multivariable Cox proportional-hazards regression models that included self-reported diseases, respiratory symptoms, smoking history, BMI, and CRP levels as the explanatory variables, SpO2 remained a significant predictor of all-cause mortality. However, after including forced expiratory volume in 1 s percent predicted (FEV1% predicted), this association was no longer significant. Mortality caused by pulmonary diseases was significantly associated with SpO2 even when FEV1% predicted was included in the model. Conclusions: Low oxygen saturation was independently associated with increased all-cause mortality and mortality caused by pulmonary diseases. When FEV1% predicted was included in the analysis, the strength of the association weakened but was still statistically significant for mortality caused by pulmonary diseases. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø BMC Pulmonary Medicine 15 1 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777 |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777 Vold, Monica Linea Aasebø, Ulf Wilsgaard, Tom Melbye, Hasse Low oxygen saturation and mortality in an adult cohort; the Tromsø Study |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777 |
description |
Published version, also available at http://dx.doi.org/10.1186/s12890-015-0003-5 Background: Oxygen saturation has been shown in risk score models to predict mortality in emergency medicine. The aim of this study was to determine whether low oxygen saturation measured by a single-point measurement by pulse oximetry (SpO2) is associated with increased mortality in the general adult population. Methods: Pulse oximetry was performed in 5,152 participants in a cross-sectional survey in Tromsø, Norway, in 2001–2002 (“Tromsø 5”). Ten-year follow-up data for all-cause mortality and cause of death were obtained from the National Population and the Cause of Death Registries, respectively. Cause of death was grouped into four categories: cardiovascular disease, cancer except lung cancer, pulmonary disease, and others. SpO2 categories were assessed as predictors for all-cause mortality and death using Cox proportional-hazards regression models after correcting for age, sex, smoking history, body mass index (BMI), C-reactive protein level, self-reported diseases, respiratory symptoms, and spirometry results. Results: The mean age was 65.8 years, and 56% were women. During the follow-up, 1,046 (20.3%) participants died. The age- and sex-adjusted hazard ratios (HRs) (95% confidence intervals) for all-cause mortality were 1.99 (1.33–2.96) for SpO2 ≤ 92% and 1.36 (1.15–1.60) for SpO2 93–95%, compared with SpO2 ≥ 96%. In the multivariable Cox proportional-hazards regression models that included self-reported diseases, respiratory symptoms, smoking history, BMI, and CRP levels as the explanatory variables, SpO2 remained a significant predictor of all-cause mortality. However, after including forced expiratory volume in 1 s percent predicted (FEV1% predicted), this association was no longer significant. Mortality caused by pulmonary diseases was significantly associated with SpO2 even when FEV1% predicted was included in the model. Conclusions: Low oxygen saturation was independently associated with increased all-cause mortality and mortality caused by pulmonary diseases. When FEV1% predicted was included in the analysis, the strength of the association weakened but was still statistically significant for mortality caused by pulmonary diseases. |
format |
Article in Journal/Newspaper |
author |
Vold, Monica Linea Aasebø, Ulf Wilsgaard, Tom Melbye, Hasse |
author_facet |
Vold, Monica Linea Aasebø, Ulf Wilsgaard, Tom Melbye, Hasse |
author_sort |
Vold, Monica Linea |
title |
Low oxygen saturation and mortality in an adult cohort; the Tromsø Study |
title_short |
Low oxygen saturation and mortality in an adult cohort; the Tromsø Study |
title_full |
Low oxygen saturation and mortality in an adult cohort; the Tromsø Study |
title_fullStr |
Low oxygen saturation and mortality in an adult cohort; the Tromsø Study |
title_full_unstemmed |
Low oxygen saturation and mortality in an adult cohort; the Tromsø Study |
title_sort |
low oxygen saturation and mortality in an adult cohort; the tromsø study |
publisher |
BioMed Central |
publishDate |
2015 |
url |
https://hdl.handle.net/10037/8876 https://doi.org/10.1186/s12890-015-0003-5 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMC Pulmonary Medicine (2015) 15:9 FRIDAID 1237978 doi:10.1186/s12890-015-0003-5 1471-2466 https://hdl.handle.net/10037/8876 URN:NBN:no-uit_munin_8459 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1186/s12890-015-0003-5 |
container_title |
BMC Pulmonary Medicine |
container_volume |
15 |
container_issue |
1 |
_version_ |
1766219119736127488 |