Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study
Published version, also available at http://dx.doi.org/DOI 10.1186/s12889-015-1573-0 Background: The American Heart Association has proposed an impact goal for the year 2020 to improve cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed cardi...
Published in: | BMC Public Health |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BioMed Central
2015
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/8874 https://doi.org/10.1186/s12889-015-1573-0 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/8874 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/8874 2023-05-15T18:34:24+02:00 Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study Wilsgaard, Tom Loehr, LR Mathiesen, Ellisiv B. Løchen, Maja-Lisa Bønaa, Kaare Harald Njølstad, Inger Heiss, G 2015-03-06 https://hdl.handle.net/10037/8874 https://doi.org/10.1186/s12889-015-1573-0 eng eng BioMed Central BMC Public Health (2015) 15:221 FRIDAID 1277775 doi:10.1186/s12889-015-1573-0 1471-2458 https://hdl.handle.net/10037/8874 URN:NBN:no-uit_munin_8460 openAccess VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 Coronary heart disease Cohort studies Lifestyle Longitudinal studies Prevention Journal article Tidsskriftartikkel Peer reviewed 2015 ftunivtroemsoe https://doi.org/10.1186/s12889-015-1573-0 2021-06-25T17:54:39Z Published version, also available at http://dx.doi.org/DOI 10.1186/s12889-015-1573-0 Background: The American Heart Association has proposed an impact goal for the year 2020 to improve cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact fraction (GIF). Methods: The health metric score was derived from ideal levels of six cardiovascular risk factors from the population-based Tromsø Study of 22,121 residents of Tromsø, Norway aged 30 to 79 years, examined in 1994–95, 2001, and 2007–08. Incident events of MI were recorded from the date of enrollment in 1994–95 to the end of 2010. Adjudication of hospitalized and out-of hospital events was performed by an independent endpoints committee based on data from hospital and out-of hospital journals, autopsy records and death certificates. Cox proportional hazard regression was used to estimate hazard ratios (HR). GIF was calculated from age stratified analysis using a case-load weighted-sum method. Bootstrapping was used to estimate 95% simulation intervals. Results: A total of 1652 MIs accrued over an average of 14.7 person-years of follow-up. Few men (0.96%) and women (3.6%) had ideal levels in all 6 metrics. 64.7% (men) and 55.7% (women) had ideal levels in 2 or 3 metrics. The age-adjusted HR per point increase in health score was 0.65 (95% confidence interval: 0.61, 0.70) in men and 0.59 (0.54, 0.64) in women. A shift of 30% of subjects from low score levels ≤3 to scores ≥4 was estimated to prevent 13.7% (11.2, 16.2) of incident MI in men and 15.9% (12.1, 19.4) in women. Conclusions: The association between the health metric score and MI indicate that close to 15% of incident MIs could be prevented by attainable and realistic improvements in the health metrics. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø BMC Public Health 15 1 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 Coronary heart disease Cohort studies Lifestyle Longitudinal studies Prevention |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 Coronary heart disease Cohort studies Lifestyle Longitudinal studies Prevention Wilsgaard, Tom Loehr, LR Mathiesen, Ellisiv B. Løchen, Maja-Lisa Bønaa, Kaare Harald Njølstad, Inger Heiss, G Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 Coronary heart disease Cohort studies Lifestyle Longitudinal studies Prevention |
description |
Published version, also available at http://dx.doi.org/DOI 10.1186/s12889-015-1573-0 Background: The American Heart Association has proposed an impact goal for the year 2020 to improve cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact fraction (GIF). Methods: The health metric score was derived from ideal levels of six cardiovascular risk factors from the population-based Tromsø Study of 22,121 residents of Tromsø, Norway aged 30 to 79 years, examined in 1994–95, 2001, and 2007–08. Incident events of MI were recorded from the date of enrollment in 1994–95 to the end of 2010. Adjudication of hospitalized and out-of hospital events was performed by an independent endpoints committee based on data from hospital and out-of hospital journals, autopsy records and death certificates. Cox proportional hazard regression was used to estimate hazard ratios (HR). GIF was calculated from age stratified analysis using a case-load weighted-sum method. Bootstrapping was used to estimate 95% simulation intervals. Results: A total of 1652 MIs accrued over an average of 14.7 person-years of follow-up. Few men (0.96%) and women (3.6%) had ideal levels in all 6 metrics. 64.7% (men) and 55.7% (women) had ideal levels in 2 or 3 metrics. The age-adjusted HR per point increase in health score was 0.65 (95% confidence interval: 0.61, 0.70) in men and 0.59 (0.54, 0.64) in women. A shift of 30% of subjects from low score levels ≤3 to scores ≥4 was estimated to prevent 13.7% (11.2, 16.2) of incident MI in men and 15.9% (12.1, 19.4) in women. Conclusions: The association between the health metric score and MI indicate that close to 15% of incident MIs could be prevented by attainable and realistic improvements in the health metrics. |
format |
Article in Journal/Newspaper |
author |
Wilsgaard, Tom Loehr, LR Mathiesen, Ellisiv B. Løchen, Maja-Lisa Bønaa, Kaare Harald Njølstad, Inger Heiss, G |
author_facet |
Wilsgaard, Tom Loehr, LR Mathiesen, Ellisiv B. Løchen, Maja-Lisa Bønaa, Kaare Harald Njølstad, Inger Heiss, G |
author_sort |
Wilsgaard, Tom |
title |
Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study |
title_short |
Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study |
title_full |
Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study |
title_fullStr |
Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study |
title_full_unstemmed |
Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study |
title_sort |
cardiovascular health and the modifiable burden of incident myocardial infarction: the tromsø study |
publisher |
BioMed Central |
publishDate |
2015 |
url |
https://hdl.handle.net/10037/8874 https://doi.org/10.1186/s12889-015-1573-0 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMC Public Health (2015) 15:221 FRIDAID 1277775 doi:10.1186/s12889-015-1573-0 1471-2458 https://hdl.handle.net/10037/8874 URN:NBN:no-uit_munin_8460 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1186/s12889-015-1573-0 |
container_title |
BMC Public Health |
container_volume |
15 |
container_issue |
1 |
_version_ |
1766219120175480832 |