Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study
Published version, also available at http://dx.doi.org/10.1186/s12882-015-0207-1 Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding....
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Language: | English |
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Online Access: | https://hdl.handle.net/10037/8846 https://doi.org/10.1186/s12882-015-0207-1 |
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ftunivtroemsoe:oai:munin.uit.no:10037/8846 2023-05-15T18:34:36+02:00 Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study Storhaug, Hilde-Merete Toft, Ingrid Norvik, Jon Viljar Jenssen, Trond Geir Eriksen, Bjørn Odvar Melsom, Toralf Løchen, Maja-Lisa Solbu, Marit Dahl 2015-12-11 https://hdl.handle.net/10037/8846 https://doi.org/10.1186/s12882-015-0207-1 eng eng BioMed Central BMC Nephrology (2015) 16:210 FRIDAID 1310718 doi:10.1186/s12882-015-0207-1 1471-2369 https://hdl.handle.net/10037/8846 URN:NBN:no-uit_munin_8421 openAccess VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 Serum uric acid Renal dysfunction Epidemiology Albumin-creatinine ratio Journal article Tidsskriftartikkel Peer reviewed 2015 ftunivtroemsoe https://doi.org/10.1186/s12882-015-0207-1 2021-06-25T17:54:39Z Published version, also available at http://dx.doi.org/10.1186/s12882-015-0207-1 Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline SUA on the development of RD. Methods: In a prospective cohort study, we assessed the associations between change in SUA during follow-up, baseline SUA and RD (defined as albumin-creatinine-ratio (ACR) ≥1.13 mg albumin/mmol creatinine and/or eGFR < 60 ml/min/1.73 m2) in a large cohort from a general population participating in the Tromsø Study (n = 2637). Participants were stratified according to tertiles of change in SUA between baseline (1994/95) and follow-up 13 years later. (upper tertile: SUA increasing group, two lower tertiles: SUA non-increasing group). Logistic regression analysis was applied with RD and each component of RD after 7 and 13 years as the dependent variables. Adjustments were made for baseline eGFR, cardiovascular risk factors, and the use of antihypertensive drugs including diuretics. Results: After excluding participants with RD at baseline, SUA increasers, compared to SUA non-increasers, had a doubled risk of RD after 7 years (odds ratio 2.00, (95 % CI 1.45, 2.75)). Odds ratio for RD in SUA increasers after 13 years was 2.18 (95 % CI 1.71, 2.79). The risk of developing ACR ≥1.13 mg/mmol alone was not significantly increased after 7 years (odds ratio 1.30 (95 % CI 0.90, 1.89), but after 13 years (odds ratio 1.43 (95 % CI 1.09, 1.86)). An increase in baseline SUA of 59 μmol/L (1 mg/dL) gave an odds ratio for RD after 13 years of 1.16 (95 % CI 1.04, 1.29). Conclusion: An increase in SUA during follow-up was associated with an increased risk of developing RD after 7 and 13 years. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø BMC Nephrology 16 1 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 Serum uric acid Renal dysfunction Epidemiology Albumin-creatinine ratio |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 Serum uric acid Renal dysfunction Epidemiology Albumin-creatinine ratio Storhaug, Hilde-Merete Toft, Ingrid Norvik, Jon Viljar Jenssen, Trond Geir Eriksen, Bjørn Odvar Melsom, Toralf Løchen, Maja-Lisa Solbu, Marit Dahl Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 Serum uric acid Renal dysfunction Epidemiology Albumin-creatinine ratio |
description |
Published version, also available at http://dx.doi.org/10.1186/s12882-015-0207-1 Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline SUA on the development of RD. Methods: In a prospective cohort study, we assessed the associations between change in SUA during follow-up, baseline SUA and RD (defined as albumin-creatinine-ratio (ACR) ≥1.13 mg albumin/mmol creatinine and/or eGFR < 60 ml/min/1.73 m2) in a large cohort from a general population participating in the Tromsø Study (n = 2637). Participants were stratified according to tertiles of change in SUA between baseline (1994/95) and follow-up 13 years later. (upper tertile: SUA increasing group, two lower tertiles: SUA non-increasing group). Logistic regression analysis was applied with RD and each component of RD after 7 and 13 years as the dependent variables. Adjustments were made for baseline eGFR, cardiovascular risk factors, and the use of antihypertensive drugs including diuretics. Results: After excluding participants with RD at baseline, SUA increasers, compared to SUA non-increasers, had a doubled risk of RD after 7 years (odds ratio 2.00, (95 % CI 1.45, 2.75)). Odds ratio for RD in SUA increasers after 13 years was 2.18 (95 % CI 1.71, 2.79). The risk of developing ACR ≥1.13 mg/mmol alone was not significantly increased after 7 years (odds ratio 1.30 (95 % CI 0.90, 1.89), but after 13 years (odds ratio 1.43 (95 % CI 1.09, 1.86)). An increase in baseline SUA of 59 μmol/L (1 mg/dL) gave an odds ratio for RD after 13 years of 1.16 (95 % CI 1.04, 1.29). Conclusion: An increase in SUA during follow-up was associated with an increased risk of developing RD after 7 and 13 years. |
format |
Article in Journal/Newspaper |
author |
Storhaug, Hilde-Merete Toft, Ingrid Norvik, Jon Viljar Jenssen, Trond Geir Eriksen, Bjørn Odvar Melsom, Toralf Løchen, Maja-Lisa Solbu, Marit Dahl |
author_facet |
Storhaug, Hilde-Merete Toft, Ingrid Norvik, Jon Viljar Jenssen, Trond Geir Eriksen, Bjørn Odvar Melsom, Toralf Løchen, Maja-Lisa Solbu, Marit Dahl |
author_sort |
Storhaug, Hilde-Merete |
title |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study |
title_short |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study |
title_full |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study |
title_fullStr |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study |
title_full_unstemmed |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study |
title_sort |
uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: the tromsø study |
publisher |
BioMed Central |
publishDate |
2015 |
url |
https://hdl.handle.net/10037/8846 https://doi.org/10.1186/s12882-015-0207-1 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMC Nephrology (2015) 16:210 FRIDAID 1310718 doi:10.1186/s12882-015-0207-1 1471-2369 https://hdl.handle.net/10037/8846 URN:NBN:no-uit_munin_8421 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1186/s12882-015-0207-1 |
container_title |
BMC Nephrology |
container_volume |
16 |
container_issue |
1 |
_version_ |
1766219426928001024 |