Health Impact Index. Development and Validation of a Method for Classifying Comorbid Disease Measured against Self-Reported Health.
The objective of this study was to develop a method of classifying comorbid conditions that accounts for both the severity and joint effects of the diseases. The Tromsø Study is a cohort study with a longitudinal design utilizing a survey approach with physical examinations in the Tromsø municipalit...
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Online Access: | https://hdl.handle.net/10037/8476 https://doi.org/10.1371/journal.pone.0148830 |
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ftunivtroemsoe:oai:munin.uit.no:10037/8476 2023-05-15T18:34:21+02:00 Health Impact Index. Development and Validation of a Method for Classifying Comorbid Disease Measured against Self-Reported Health. Lorem, Geir F Schirmer, Henrik Emaus, Nina 2016-02-05 https://hdl.handle.net/10037/8476 https://doi.org/10.1371/journal.pone.0148830 eng eng Public Library of Science http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148830 PLoS ONE 2016, 11(2) FRIDAID 1334207 doi:10.1371/journal.pone.0148830 1932-6203 https://hdl.handle.net/10037/8476 URN:NBN:no-uit_munin_8052 openAccess Epidemiologi / Epidemiology VDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Midical sciences: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 Journal article Tidsskriftartikkel Peer reviewed 2016 ftunivtroemsoe https://doi.org/10.1371/journal.pone.0148830 2021-06-25T17:54:34Z The objective of this study was to develop a method of classifying comorbid conditions that accounts for both the severity and joint effects of the diseases. The Tromsø Study is a cohort study with a longitudinal design utilizing a survey approach with physical examinations in the Tromsø municipality from 1974 to 2008, where in total 40051 subjects participated. We used Tromsø 4 as reference population and the Norwegian Institute of Public Health (FHI) panel as validation population. Ordinal regression was used to assess the effect of comorbid disease on Self-Reported Health (SRH). The model is controlled for interaction between diseases, mental health, age, and gender. The health impact index estimated levels of SRH. The comparison of predicted and observed SRH showed no significant differences. Spearman’s correlation showed that increasing levels of comorbidity were related to lower levels of SRH (RS = -0.36, p <.001). The Charlson Comorbidity Index (CCI) was also associated with SRH (r = -.25, p <.001). When focusing on only individuals with a comorbid disease, the relation between SRH and the Health Impact Index (HII) was strengthened (r = -.42, p <.001), while the association between SRH and CCI was attenuated (r = -.14, p <.001). CCI was designed to control for comorbid conditions when survival/ mortality is the outcome of interest but is inaccurate when the outcome is SRH. We conclude that HII should be used when SRH is not available, and well-being or quality of survival/life is the outcome of interest. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø PLOS ONE 11 2 e0148830 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
Epidemiologi / Epidemiology VDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Midical sciences: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 |
spellingShingle |
Epidemiologi / Epidemiology VDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Midical sciences: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 Lorem, Geir F Schirmer, Henrik Emaus, Nina Health Impact Index. Development and Validation of a Method for Classifying Comorbid Disease Measured against Self-Reported Health. |
topic_facet |
Epidemiologi / Epidemiology VDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Midical sciences: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 |
description |
The objective of this study was to develop a method of classifying comorbid conditions that accounts for both the severity and joint effects of the diseases. The Tromsø Study is a cohort study with a longitudinal design utilizing a survey approach with physical examinations in the Tromsø municipality from 1974 to 2008, where in total 40051 subjects participated. We used Tromsø 4 as reference population and the Norwegian Institute of Public Health (FHI) panel as validation population. Ordinal regression was used to assess the effect of comorbid disease on Self-Reported Health (SRH). The model is controlled for interaction between diseases, mental health, age, and gender. The health impact index estimated levels of SRH. The comparison of predicted and observed SRH showed no significant differences. Spearman’s correlation showed that increasing levels of comorbidity were related to lower levels of SRH (RS = -0.36, p <.001). The Charlson Comorbidity Index (CCI) was also associated with SRH (r = -.25, p <.001). When focusing on only individuals with a comorbid disease, the relation between SRH and the Health Impact Index (HII) was strengthened (r = -.42, p <.001), while the association between SRH and CCI was attenuated (r = -.14, p <.001). CCI was designed to control for comorbid conditions when survival/ mortality is the outcome of interest but is inaccurate when the outcome is SRH. We conclude that HII should be used when SRH is not available, and well-being or quality of survival/life is the outcome of interest. |
format |
Article in Journal/Newspaper |
author |
Lorem, Geir F Schirmer, Henrik Emaus, Nina |
author_facet |
Lorem, Geir F Schirmer, Henrik Emaus, Nina |
author_sort |
Lorem, Geir F |
title |
Health Impact Index. Development and Validation of a Method for Classifying Comorbid Disease Measured against Self-Reported Health. |
title_short |
Health Impact Index. Development and Validation of a Method for Classifying Comorbid Disease Measured against Self-Reported Health. |
title_full |
Health Impact Index. Development and Validation of a Method for Classifying Comorbid Disease Measured against Self-Reported Health. |
title_fullStr |
Health Impact Index. Development and Validation of a Method for Classifying Comorbid Disease Measured against Self-Reported Health. |
title_full_unstemmed |
Health Impact Index. Development and Validation of a Method for Classifying Comorbid Disease Measured against Self-Reported Health. |
title_sort |
health impact index. development and validation of a method for classifying comorbid disease measured against self-reported health. |
publisher |
Public Library of Science |
publishDate |
2016 |
url |
https://hdl.handle.net/10037/8476 https://doi.org/10.1371/journal.pone.0148830 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148830 PLoS ONE 2016, 11(2) FRIDAID 1334207 doi:10.1371/journal.pone.0148830 1932-6203 https://hdl.handle.net/10037/8476 URN:NBN:no-uit_munin_8052 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0148830 |
container_title |
PLOS ONE |
container_volume |
11 |
container_issue |
2 |
container_start_page |
e0148830 |
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1766219055212003328 |