Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study
This is the accepted manuscript version. Published version, with slightly altered title, is available in Journal of Thrombosis and Haemostasis 12(2014) Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovasc...
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Blackwell Publishing
2014
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Online Access: | https://hdl.handle.net/10037/8229 https://doi.org/10.1111/jth.12498 |
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ftunivtroemsoe:oai:munin.uit.no:10037/8229 2023-05-15T18:34:14+02:00 Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study Lerstad, Gunhild Brodin, Ellen Elisabeth Enga, Kristin Jorde, Rolf Schirmer, Henrik Njølstad, Inger Svartberg, Johan Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2014-03-05 https://hdl.handle.net/10037/8229 https://doi.org/10.1111/jth.12498 eng eng Blackwell Publishing Journal of Thrombosis and Haemostasis 12(2014) nr. 3 s. 313-319 FRIDAID 1091084 doi:10.1111/jth.12498 1538-7933 https://hdl.handle.net/10037/8229 URN:NBN:no-uit_munin_7811 openAccess Cardiovascular Diseases Diabetes Mellitus Glycated Hemoglobins Glucose Metabolic Disorders Venous Thromboembolism VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 Journal article Tidsskriftartikkel Peer reviewed 2014 ftunivtroemsoe https://doi.org/10.1111/jth.12498 2021-06-25T17:54:27Z This is the accepted manuscript version. Published version, with slightly altered title, is available in Journal of Thrombosis and Haemostasis 12(2014) Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) who participated in one or more surveys of the Tromsø study (Tromsø 4; 1994-95, Tromsø 5; 2001-2, and Tromsø 6; 2007-8). All subjects were followed, and incident VTE events were recorded through December 31, 2010. Results: There were 333 validated first VTE events, of which 137 were unprovoked, during a median follow-up of 7.1 years. HbA1c was not associated with future risk of VTE in analysis treating HbA1c as a continuous variable, or in categorized analyses. The risk of VTE increased by 5% per 1 SD (0.7%) increase in HbA1c (multivariableadjusted HR 1.05; 95% CI 0.97-1.14), and subjects with HbA1c ≥ 6.5% had 27% higher risk compared to those with HbA1c below 5.7% (multivariable-adjusted HR 1.27; 95% CI 0.72-2.26). There was no significant linear trend for increased risk of VTE across categories of HbA1c (p=0.27). Conclusions: Serum levels of HbA1c were not associated with future risk of VTE in multivariable analysis. Our findings suggest that hyperglycemia does not play an important role in the pathogenesis of VTE Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Journal of Thrombosis and Haemostasis 12 3 313 319 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
Cardiovascular Diseases Diabetes Mellitus Glycated Hemoglobins Glucose Metabolic Disorders Venous Thromboembolism VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 |
spellingShingle |
Cardiovascular Diseases Diabetes Mellitus Glycated Hemoglobins Glucose Metabolic Disorders Venous Thromboembolism VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 Lerstad, Gunhild Brodin, Ellen Elisabeth Enga, Kristin Jorde, Rolf Schirmer, Henrik Njølstad, Inger Svartberg, Johan Brækkan, Sigrid Kufaas Hansen, John-Bjarne Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study |
topic_facet |
Cardiovascular Diseases Diabetes Mellitus Glycated Hemoglobins Glucose Metabolic Disorders Venous Thromboembolism VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 |
description |
This is the accepted manuscript version. Published version, with slightly altered title, is available in Journal of Thrombosis and Haemostasis 12(2014) Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) who participated in one or more surveys of the Tromsø study (Tromsø 4; 1994-95, Tromsø 5; 2001-2, and Tromsø 6; 2007-8). All subjects were followed, and incident VTE events were recorded through December 31, 2010. Results: There were 333 validated first VTE events, of which 137 were unprovoked, during a median follow-up of 7.1 years. HbA1c was not associated with future risk of VTE in analysis treating HbA1c as a continuous variable, or in categorized analyses. The risk of VTE increased by 5% per 1 SD (0.7%) increase in HbA1c (multivariableadjusted HR 1.05; 95% CI 0.97-1.14), and subjects with HbA1c ≥ 6.5% had 27% higher risk compared to those with HbA1c below 5.7% (multivariable-adjusted HR 1.27; 95% CI 0.72-2.26). There was no significant linear trend for increased risk of VTE across categories of HbA1c (p=0.27). Conclusions: Serum levels of HbA1c were not associated with future risk of VTE in multivariable analysis. Our findings suggest that hyperglycemia does not play an important role in the pathogenesis of VTE |
format |
Article in Journal/Newspaper |
author |
Lerstad, Gunhild Brodin, Ellen Elisabeth Enga, Kristin Jorde, Rolf Schirmer, Henrik Njølstad, Inger Svartberg, Johan Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Lerstad, Gunhild Brodin, Ellen Elisabeth Enga, Kristin Jorde, Rolf Schirmer, Henrik Njølstad, Inger Svartberg, Johan Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Lerstad, Gunhild |
title |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study |
title_short |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study |
title_full |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study |
title_fullStr |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study |
title_full_unstemmed |
Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study |
title_sort |
hyperglycemia, assessed by hba1c, and future risk of venous thromboembolism - the tromsø study |
publisher |
Blackwell Publishing |
publishDate |
2014 |
url |
https://hdl.handle.net/10037/8229 https://doi.org/10.1111/jth.12498 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Journal of Thrombosis and Haemostasis 12(2014) nr. 3 s. 313-319 FRIDAID 1091084 doi:10.1111/jth.12498 1538-7933 https://hdl.handle.net/10037/8229 URN:NBN:no-uit_munin_7811 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1111/jth.12498 |
container_title |
Journal of Thrombosis and Haemostasis |
container_volume |
12 |
container_issue |
3 |
container_start_page |
313 |
op_container_end_page |
319 |
_version_ |
1766218898693160960 |