Impact of incident venous thromboembolism on risk of arterial thrombotic diseases
This is the accepted manuscript version. Published version of the article is available in: Circulation 129(2014) no. 8 BACKGROUND: Growing evidence supports an association between venous thromboembolism (VTE) and arterial thrombotic diseases (ie, myocardial infarction and ischemic stroke). We aimed...
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American Heart Association
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Online Access: | https://hdl.handle.net/10037/8225 https://doi.org/10.1161/CIRCULATIONAHA.113.004168 |
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ftunivtroemsoe:oai:munin.uit.no:10037/8225 2023-05-15T18:34:50+02:00 Impact of incident venous thromboembolism on risk of arterial thrombotic diseases Lind, Caroline Flinterman, Linda E. Enga, Kristin Severinsen, Marianne T Kristensen, Søren R Brækkan, Sigrid Kufaas Mathiesen, Ellisiv B. Njølstad, Inger Cannegieter, Suzanne C. Overvad, Kim Hansen, John-Bjarne 2013-11-22 https://hdl.handle.net/10037/8225 https://doi.org/10.1161/CIRCULATIONAHA.113.004168 eng eng American Heart Association Circulation 129(2014) nr. 8 s. 855-863 FRIDAID 1091659 doi:10.1161/CIRCULATIONAHA.113.004168 0009-7322 https://hdl.handle.net/10037/8225 URN:NBN:no-uit_munin_7808 openAccess myocardial infarction stroke venous thrombosis VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 Journal article Tidsskriftartikkel Peer reviewed 2013 ftunivtroemsoe https://doi.org/10.1161/CIRCULATIONAHA.113.004168 2021-06-25T17:54:27Z This is the accepted manuscript version. Published version of the article is available in: Circulation 129(2014) no. 8 BACKGROUND: Growing evidence supports an association between venous thromboembolism (VTE) and arterial thrombotic diseases (ie, myocardial infarction and ischemic stroke). We aimed to study the association between VTE and future arterial events and to determine the population attributable risk of arterial events by VTE in a large prospective cohort recruited from the general population. METHODS AND RESULTS: In 1994 to 1995 and 1993 to 1997, 81 687 subjects were included in the Tromsø Study and in the Diet, Cancer and Health Study and followed up to the date of incident venous and arterial events (myocardial infarction or ischemic stroke), death or migration, or to the end of the study period (2010 and 2008, respectively). There were 1208 cases of VTE and 90 subsequent arterial events during a median follow-up of 12.2 years. An association between VTE and future arterial events was found in all women and men aged <65 years but not in men aged >65 years. Women <65 years old with VTE had 3.3-fold higher risk of arterial disease (adjusted hazard ratio, 3.28; 95% confidence interval, 1.69-6.35) compared with women of the same age without VTE. The corresponding hazard ratio in men aged <65 years was 2.06 (95% confidence interval, 1.32-3.20). Only 0.9% of the arterial events were attributed to VTE, and the VTE explained 63.8% of the risk of arterial events among VTE patients. CONCLUSIONS: Our findings imply that women and young men with VTE have higher risk of arterial thrombotic disease than those without VTE. However, only 1% of the arterial thrombotic events in the population are attributed to VTE. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Circulation 129 8 855 863 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
myocardial infarction stroke venous thrombosis VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 |
spellingShingle |
myocardial infarction stroke venous thrombosis VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 Lind, Caroline Flinterman, Linda E. Enga, Kristin Severinsen, Marianne T Kristensen, Søren R Brækkan, Sigrid Kufaas Mathiesen, Ellisiv B. Njølstad, Inger Cannegieter, Suzanne C. Overvad, Kim Hansen, John-Bjarne Impact of incident venous thromboembolism on risk of arterial thrombotic diseases |
topic_facet |
myocardial infarction stroke venous thrombosis VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 |
description |
This is the accepted manuscript version. Published version of the article is available in: Circulation 129(2014) no. 8 BACKGROUND: Growing evidence supports an association between venous thromboembolism (VTE) and arterial thrombotic diseases (ie, myocardial infarction and ischemic stroke). We aimed to study the association between VTE and future arterial events and to determine the population attributable risk of arterial events by VTE in a large prospective cohort recruited from the general population. METHODS AND RESULTS: In 1994 to 1995 and 1993 to 1997, 81 687 subjects were included in the Tromsø Study and in the Diet, Cancer and Health Study and followed up to the date of incident venous and arterial events (myocardial infarction or ischemic stroke), death or migration, or to the end of the study period (2010 and 2008, respectively). There were 1208 cases of VTE and 90 subsequent arterial events during a median follow-up of 12.2 years. An association between VTE and future arterial events was found in all women and men aged <65 years but not in men aged >65 years. Women <65 years old with VTE had 3.3-fold higher risk of arterial disease (adjusted hazard ratio, 3.28; 95% confidence interval, 1.69-6.35) compared with women of the same age without VTE. The corresponding hazard ratio in men aged <65 years was 2.06 (95% confidence interval, 1.32-3.20). Only 0.9% of the arterial events were attributed to VTE, and the VTE explained 63.8% of the risk of arterial events among VTE patients. CONCLUSIONS: Our findings imply that women and young men with VTE have higher risk of arterial thrombotic disease than those without VTE. However, only 1% of the arterial thrombotic events in the population are attributed to VTE. |
format |
Article in Journal/Newspaper |
author |
Lind, Caroline Flinterman, Linda E. Enga, Kristin Severinsen, Marianne T Kristensen, Søren R Brækkan, Sigrid Kufaas Mathiesen, Ellisiv B. Njølstad, Inger Cannegieter, Suzanne C. Overvad, Kim Hansen, John-Bjarne |
author_facet |
Lind, Caroline Flinterman, Linda E. Enga, Kristin Severinsen, Marianne T Kristensen, Søren R Brækkan, Sigrid Kufaas Mathiesen, Ellisiv B. Njølstad, Inger Cannegieter, Suzanne C. Overvad, Kim Hansen, John-Bjarne |
author_sort |
Lind, Caroline |
title |
Impact of incident venous thromboembolism on risk of arterial thrombotic diseases |
title_short |
Impact of incident venous thromboembolism on risk of arterial thrombotic diseases |
title_full |
Impact of incident venous thromboembolism on risk of arterial thrombotic diseases |
title_fullStr |
Impact of incident venous thromboembolism on risk of arterial thrombotic diseases |
title_full_unstemmed |
Impact of incident venous thromboembolism on risk of arterial thrombotic diseases |
title_sort |
impact of incident venous thromboembolism on risk of arterial thrombotic diseases |
publisher |
American Heart Association |
publishDate |
2013 |
url |
https://hdl.handle.net/10037/8225 https://doi.org/10.1161/CIRCULATIONAHA.113.004168 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Circulation 129(2014) nr. 8 s. 855-863 FRIDAID 1091659 doi:10.1161/CIRCULATIONAHA.113.004168 0009-7322 https://hdl.handle.net/10037/8225 URN:NBN:no-uit_munin_7808 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1161/CIRCULATIONAHA.113.004168 |
container_title |
Circulation |
container_volume |
129 |
container_issue |
8 |
container_start_page |
855 |
op_container_end_page |
863 |
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1766219781640290304 |