No lipid lowering effect of vitamin D supplements found on statin users.
Background Tromsø endocrine research group has performed multiple RCTs with vitamin D supplements/placebo and effects on different outcomes. Compiling data from four of these studies I tested an hypothesis established by Kane et al. in 2013, which suggests that vitamin D supplements have a significa...
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ftunivtroemsoe:oai:munin.uit.no:10037/8179 2023-05-15T18:34:29+02:00 No lipid lowering effect of vitamin D supplements found on statin users. Johnsen, Martin Solvang 2015-08-26 https://hdl.handle.net/10037/8179 eng eng UiT Norges arktiske universitet UiT The Arctic University of Norway https://hdl.handle.net/10037/8179 URN:NBN:no-uit_munin_7764 openAccess Copyright 2015 The Author(s) Statin Vitamin D VDP::Medisinske Fag: 700 VDP::Medical disciplines: 700 MED-3950 Master thesis Mastergradsoppgave 2015 ftunivtroemsoe 2021-06-25T17:54:27Z Background Tromsø endocrine research group has performed multiple RCTs with vitamin D supplements/placebo and effects on different outcomes. Compiling data from four of these studies I tested an hypothesis established by Kane et al. in 2013, which suggests that vitamin D supplements have a significant lipid lowering effect in statin users. Retesting hypotheses in general is vital to the scientific community. By using patient data from Tromsø endocrine research group I wanted to retest this new hypothesis because it has not been confirmed by other studies. Method To test the hypothesis I pooled subjects from four vitamin D intervention studies and split the subjects into statin users and non-statin users. I then performed independent samples t-test to see if vitamin D-supplements during 6-12 months had a lipid lowering effect compared to placebo. I performed correlations between baseline levels of vitamin D and lipids. To adjust for confounding factors in the correlations I used linear regression with age, sex and BMI as covariates. Results At baseline serum HDL, Apo-A and triglycerides correlated significantly with vitamin D (p < 0.01). After adjusting for confounders the baseline HDL levels correlated significantly with vitamin D (p=0.001). I found no significant results in the t-test or the linear regressions on changes in lipid levels based on vitamin D treatment. Conclusions I found no clear significant lipid-lowering effect of vitamin D supplementation compared to placebo in neither statin users nor non-statin users. After adjusting for confounders, serum HDL still remained significantly correlated with vitamin D at baseline. Master Thesis Tromsø University of Tromsø: Munin Open Research Archive Kane ENVELOPE(-63.038,-63.038,-73.952,-73.952) Tromsø |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
Statin Vitamin D VDP::Medisinske Fag: 700 VDP::Medical disciplines: 700 MED-3950 |
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Statin Vitamin D VDP::Medisinske Fag: 700 VDP::Medical disciplines: 700 MED-3950 Johnsen, Martin Solvang No lipid lowering effect of vitamin D supplements found on statin users. |
topic_facet |
Statin Vitamin D VDP::Medisinske Fag: 700 VDP::Medical disciplines: 700 MED-3950 |
description |
Background Tromsø endocrine research group has performed multiple RCTs with vitamin D supplements/placebo and effects on different outcomes. Compiling data from four of these studies I tested an hypothesis established by Kane et al. in 2013, which suggests that vitamin D supplements have a significant lipid lowering effect in statin users. Retesting hypotheses in general is vital to the scientific community. By using patient data from Tromsø endocrine research group I wanted to retest this new hypothesis because it has not been confirmed by other studies. Method To test the hypothesis I pooled subjects from four vitamin D intervention studies and split the subjects into statin users and non-statin users. I then performed independent samples t-test to see if vitamin D-supplements during 6-12 months had a lipid lowering effect compared to placebo. I performed correlations between baseline levels of vitamin D and lipids. To adjust for confounding factors in the correlations I used linear regression with age, sex and BMI as covariates. Results At baseline serum HDL, Apo-A and triglycerides correlated significantly with vitamin D (p < 0.01). After adjusting for confounders the baseline HDL levels correlated significantly with vitamin D (p=0.001). I found no significant results in the t-test or the linear regressions on changes in lipid levels based on vitamin D treatment. Conclusions I found no clear significant lipid-lowering effect of vitamin D supplementation compared to placebo in neither statin users nor non-statin users. After adjusting for confounders, serum HDL still remained significantly correlated with vitamin D at baseline. |
format |
Master Thesis |
author |
Johnsen, Martin Solvang |
author_facet |
Johnsen, Martin Solvang |
author_sort |
Johnsen, Martin Solvang |
title |
No lipid lowering effect of vitamin D supplements found on statin users. |
title_short |
No lipid lowering effect of vitamin D supplements found on statin users. |
title_full |
No lipid lowering effect of vitamin D supplements found on statin users. |
title_fullStr |
No lipid lowering effect of vitamin D supplements found on statin users. |
title_full_unstemmed |
No lipid lowering effect of vitamin D supplements found on statin users. |
title_sort |
no lipid lowering effect of vitamin d supplements found on statin users. |
publisher |
UiT Norges arktiske universitet |
publishDate |
2015 |
url |
https://hdl.handle.net/10037/8179 |
long_lat |
ENVELOPE(-63.038,-63.038,-73.952,-73.952) |
geographic |
Kane Tromsø |
geographic_facet |
Kane Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://hdl.handle.net/10037/8179 URN:NBN:no-uit_munin_7764 |
op_rights |
openAccess Copyright 2015 The Author(s) |
_version_ |
1766219240856092672 |