Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions
Background: Longitudinal monitoring studies of persistent organic pollutants (POPs) in human populations are important to better understand changes with time and age, and for future predictions. Objectives: We sought to describe serum POP time trends on an individual level, investigate age–period–co...
Published in: | Environmental Health Perspectives |
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National Institute of Environmental Health Sciences
2013
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Online Access: | https://hdl.handle.net/10037/6070 https://doi.org/10.1289/ehp.1206317 |
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ftunivtroemsoe:oai:munin.uit.no:10037/6070 2023-05-15T17:43:24+02:00 Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions Nøst, Therese Haugdahl Breivik, Knut Fuskevåg, Ole-Martin Nieboer, Evert Odland, Jon Øyvind Sandanger, Torkjel Manning 2013 https://hdl.handle.net/10037/6070 https://doi.org/10.1289/ehp.1206317 eng eng National Institute of Environmental Health Sciences Environmental Health Perspectives 121(2013) nr. 11-12 s. 1292-1298 FRIDAID 1072176 http://dx.doi.org/10.1289/ehp.1206317 0091-6765 https://hdl.handle.net/10037/6070 URN:NBN:no-uit_munin_5770 openAccess VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Journal article Tidsskriftartikkel Peer reviewed 2013 ftunivtroemsoe https://doi.org/10.1289/ehp.1206317 2021-06-25T17:53:49Z Background: Longitudinal monitoring studies of persistent organic pollutants (POPs) in human populations are important to better understand changes with time and age, and for future predictions. Objectives: We sought to describe serum POP time trends on an individual level, investigate age–period–cohort effects, and compare predicted polychlorinated biphenyl (PCB) concentrations to measured values. Methods: Serum was sampled in 1979, 1986, 1994, 2001, and 2007 from a cohort of 53 men in Northern Norway and analyzed for 41 POPs. Time period, age, and birth cohort effects were assessed by graphical analyses and mixed-effect models. We derived the predicted concentrations of four PCBs for each sampling year using the CoZMoMAN model. Results: The median decreases in summed serum POP concentrations (lipid-adjusted) in 1986, 1994, 2001, and 2007 relative to 1979 were –22%, –52%, –54%, and –68%, respectively. We observed substantial declines in all POP groups with the exception of chlordanes. Time period (reflected by sampling year) was the strongest descriptor of changes in PCB-153 concentrations. Predicted PCB-153 concentrations were consistent with measured concentrations in the study population. Conclusions: Our results suggest substantial intraindividual declines in serum concentrations of legacy POPs from 1979 to 2007 in men from Northern Norway. These changes are consistent with reduced environmental exposure during these 30 years and highlight the relation between historic emissions and POP concentrations measured in humans. Observed data and interpretations are supported by estimates from the CoZMoMAN emission-based model. A longitudinal decrease in concentrations with age was evident for all birth cohorts. Overall, our findings support the relevance of age–period–cohort effects to human biomonitoring of environmental contaminants. Article in Journal/Newspaper Northern Norway University of Tromsø: Munin Open Research Archive Norway Environmental Health Perspectives 121 11-12 1292 1298 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Nøst, Therese Haugdahl Breivik, Knut Fuskevåg, Ole-Martin Nieboer, Evert Odland, Jon Øyvind Sandanger, Torkjel Manning Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
description |
Background: Longitudinal monitoring studies of persistent organic pollutants (POPs) in human populations are important to better understand changes with time and age, and for future predictions. Objectives: We sought to describe serum POP time trends on an individual level, investigate age–period–cohort effects, and compare predicted polychlorinated biphenyl (PCB) concentrations to measured values. Methods: Serum was sampled in 1979, 1986, 1994, 2001, and 2007 from a cohort of 53 men in Northern Norway and analyzed for 41 POPs. Time period, age, and birth cohort effects were assessed by graphical analyses and mixed-effect models. We derived the predicted concentrations of four PCBs for each sampling year using the CoZMoMAN model. Results: The median decreases in summed serum POP concentrations (lipid-adjusted) in 1986, 1994, 2001, and 2007 relative to 1979 were –22%, –52%, –54%, and –68%, respectively. We observed substantial declines in all POP groups with the exception of chlordanes. Time period (reflected by sampling year) was the strongest descriptor of changes in PCB-153 concentrations. Predicted PCB-153 concentrations were consistent with measured concentrations in the study population. Conclusions: Our results suggest substantial intraindividual declines in serum concentrations of legacy POPs from 1979 to 2007 in men from Northern Norway. These changes are consistent with reduced environmental exposure during these 30 years and highlight the relation between historic emissions and POP concentrations measured in humans. Observed data and interpretations are supported by estimates from the CoZMoMAN emission-based model. A longitudinal decrease in concentrations with age was evident for all birth cohorts. Overall, our findings support the relevance of age–period–cohort effects to human biomonitoring of environmental contaminants. |
format |
Article in Journal/Newspaper |
author |
Nøst, Therese Haugdahl Breivik, Knut Fuskevåg, Ole-Martin Nieboer, Evert Odland, Jon Øyvind Sandanger, Torkjel Manning |
author_facet |
Nøst, Therese Haugdahl Breivik, Knut Fuskevåg, Ole-Martin Nieboer, Evert Odland, Jon Øyvind Sandanger, Torkjel Manning |
author_sort |
Nøst, Therese Haugdahl |
title |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_short |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_full |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_fullStr |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_full_unstemmed |
Persistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictions |
title_sort |
persistent organic pollutants in norwegian men from 1979 to 2007: intraindividual changes, age–period–cohort effects, and model predictions |
publisher |
National Institute of Environmental Health Sciences |
publishDate |
2013 |
url |
https://hdl.handle.net/10037/6070 https://doi.org/10.1289/ehp.1206317 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_relation |
Environmental Health Perspectives 121(2013) nr. 11-12 s. 1292-1298 FRIDAID 1072176 http://dx.doi.org/10.1289/ehp.1206317 0091-6765 https://hdl.handle.net/10037/6070 URN:NBN:no-uit_munin_5770 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1289/ehp.1206317 |
container_title |
Environmental Health Perspectives |
container_volume |
121 |
container_issue |
11-12 |
container_start_page |
1292 |
op_container_end_page |
1298 |
_version_ |
1766145458449678336 |