Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study
Background: The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, is...
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ftunivtroemsoe:oai:munin.uit.no:10037/5877 2023-05-15T18:34:50+02:00 Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study Storhaug, Hilde-Merete Norvik, Jon Viljar Toft, Ingrid Eriksen, Bjørn Odvar Løchen, Maja-Lisa Zykova, Svetlana Solbu, Marit Dahl White, Sarah Chadban, S Jenssen, Trond Geir 2013 https://hdl.handle.net/10037/5877 https://doi.org/10.1186/1471-2261-13-115 eng eng BioMed Central BMC Cardiovascular Disorders (2013), vol. 13:115 FRIDAID 1088350 http://dx.doi.org/10.1186/1471-2261-13-115 1471-2261 https://hdl.handle.net/10037/5877 URN:NBN:no-uit_munin_5575 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Journal article Tidsskriftartikkel Peer reviewed 2013 ftunivtroemsoe https://doi.org/10.1186/1471-2261-13-115 2021-06-25T17:53:46Z Background: The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional and non-traditional risk factors for cardiovascular disease included in the model. Methods: A population-based prospective cohort study was performed among 2696 men and 3004 women. Endpoints were all-cause mortality after 15 years, and fatal or non-fatal myocardial infarction (MI) and ischemic stroke after 12 years. Results: 1433 deaths, 659 MIs and 430 ischemic strokes occurred during follow-up. Fully adjusted Cox regression analyses showed that per 1 SD (87 μmol/L) increase in serum uric acid level, the risk of all-cause mortality increased in both genders (hazard ratios, HR men; 1.11, 95% CI 1.02-1.20, women; 1.16, 1.05-1.29). HRs and 95% CI for stroke were 1.31, 1.14-1.50 in men, 1.13, 0.94-1.36 in women, and 1.22 (1.09, 1.35) in the overall population. No independent associations were observed with MI. Conclusion: Serum uric acid was associated with all-cause mortality in men and women, even after adjustment for blood pressure, estimated GFR, urinary albumin/creatinine ratio, drug intake and traditional cardiovascular risk factors. After the same adjustments, serum uric acid was associated with 31% increased risk of stroke in men. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø BMC Cardiovascular Disorders 13 1 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Storhaug, Hilde-Merete Norvik, Jon Viljar Toft, Ingrid Eriksen, Bjørn Odvar Løchen, Maja-Lisa Zykova, Svetlana Solbu, Marit Dahl White, Sarah Chadban, S Jenssen, Trond Geir Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
description |
Background: The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional and non-traditional risk factors for cardiovascular disease included in the model. Methods: A population-based prospective cohort study was performed among 2696 men and 3004 women. Endpoints were all-cause mortality after 15 years, and fatal or non-fatal myocardial infarction (MI) and ischemic stroke after 12 years. Results: 1433 deaths, 659 MIs and 430 ischemic strokes occurred during follow-up. Fully adjusted Cox regression analyses showed that per 1 SD (87 μmol/L) increase in serum uric acid level, the risk of all-cause mortality increased in both genders (hazard ratios, HR men; 1.11, 95% CI 1.02-1.20, women; 1.16, 1.05-1.29). HRs and 95% CI for stroke were 1.31, 1.14-1.50 in men, 1.13, 0.94-1.36 in women, and 1.22 (1.09, 1.35) in the overall population. No independent associations were observed with MI. Conclusion: Serum uric acid was associated with all-cause mortality in men and women, even after adjustment for blood pressure, estimated GFR, urinary albumin/creatinine ratio, drug intake and traditional cardiovascular risk factors. After the same adjustments, serum uric acid was associated with 31% increased risk of stroke in men. |
format |
Article in Journal/Newspaper |
author |
Storhaug, Hilde-Merete Norvik, Jon Viljar Toft, Ingrid Eriksen, Bjørn Odvar Løchen, Maja-Lisa Zykova, Svetlana Solbu, Marit Dahl White, Sarah Chadban, S Jenssen, Trond Geir |
author_facet |
Storhaug, Hilde-Merete Norvik, Jon Viljar Toft, Ingrid Eriksen, Bjørn Odvar Løchen, Maja-Lisa Zykova, Svetlana Solbu, Marit Dahl White, Sarah Chadban, S Jenssen, Trond Geir |
author_sort |
Storhaug, Hilde-Merete |
title |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_short |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_full |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_fullStr |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_full_unstemmed |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_sort |
uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from the tromsø study |
publisher |
BioMed Central |
publishDate |
2013 |
url |
https://hdl.handle.net/10037/5877 https://doi.org/10.1186/1471-2261-13-115 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMC Cardiovascular Disorders (2013), vol. 13:115 FRIDAID 1088350 http://dx.doi.org/10.1186/1471-2261-13-115 1471-2261 https://hdl.handle.net/10037/5877 URN:NBN:no-uit_munin_5575 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1186/1471-2261-13-115 |
container_title |
BMC Cardiovascular Disorders |
container_volume |
13 |
container_issue |
1 |
_version_ |
1766219780479516672 |