Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008
This paper is part of Marit Herder's doctoral thesis, available in Munin at http://hdl.handle.net/10037/5723 Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in car...
Published in: | Arteriosclerosis, Thrombosis, and Vascular Biology |
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Language: | English |
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American Heart Association
2013
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Online Access: | https://hdl.handle.net/10037/5734 https://doi.org/10.1161/ATVBAHA.112.300767 |
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ftunivtroemsoe:oai:munin.uit.no:10037/5734 2023-05-15T18:33:54+02:00 Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008 Herder, Marit Arntzen, Kjell Arne Johnsen, Stein Harald Eggen, Anne Elise Mathiesen, Ellisiv B. 2013 https://hdl.handle.net/10037/5734 https://doi.org/10.1161/ATVBAHA.112.300767 eng eng American Heart Association Arteriosclerosis, Thrombosis and Vascular Biology 33(2013) nr. 4 s. 858-U521 FRIDAID 1030673 http://dx.doi.org/10.1161/ATVBAHA.112.300767 1079-5642 https://hdl.handle.net/10037/5734 URN:NBN:no-uit_munin_5442 openAccess VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Journal article Tidsskriftartikkel Peer reviewed 2013 ftunivtroemsoe https://doi.org/10.1161/ATVBAHA.112.300767 2021-06-25T17:53:44Z This paper is part of Marit Herder's doctoral thesis, available in Munin at http://hdl.handle.net/10037/5723 Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in carotid intima media thickness and total plaque area in a general population. Subjects were 1532 women and 1442 men who participated in a longitudinal population-based study with ultrasound examination of intima media thickness and total plaque area in the right carotid artery at baseline and after 13 years follow-up. Long-term use of LLD was defined as use for >5 years, any-time use of LLD was defined as use at baseline or at 6 years or at 13 years of follow-up. In multivariable models adjusted for age, sex, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, prevalent cardiovascular disease, and daily smoking, long-term use of LLD had a protective effect on progression of both intima media thickness (β=–0.0387 mm; P=0.002) and total plaque area (β=–0.400 mm2; P=0.006). There was a weaker protective effect of any-time use of LLD on progression of intima media thickness (β=–0.024 mm; P=0.046) and total plaque area (β=–0.318 mm2; P=0.06). LLD protected against progression of carotid atherosclerosis. The protective effect was strongest in long-term users. Article in Journal/Newspaper Tromso Tromso University of Tromsø: Munin Open Research Archive Tromso ENVELOPE(16.546,16.546,68.801,68.801) Arteriosclerosis, Thrombosis, and Vascular Biology 33 4 858 862 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Herder, Marit Arntzen, Kjell Arne Johnsen, Stein Harald Eggen, Anne Elise Mathiesen, Ellisiv B. Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008 |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
description |
This paper is part of Marit Herder's doctoral thesis, available in Munin at http://hdl.handle.net/10037/5723 Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in carotid intima media thickness and total plaque area in a general population. Subjects were 1532 women and 1442 men who participated in a longitudinal population-based study with ultrasound examination of intima media thickness and total plaque area in the right carotid artery at baseline and after 13 years follow-up. Long-term use of LLD was defined as use for >5 years, any-time use of LLD was defined as use at baseline or at 6 years or at 13 years of follow-up. In multivariable models adjusted for age, sex, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, prevalent cardiovascular disease, and daily smoking, long-term use of LLD had a protective effect on progression of both intima media thickness (β=–0.0387 mm; P=0.002) and total plaque area (β=–0.400 mm2; P=0.006). There was a weaker protective effect of any-time use of LLD on progression of intima media thickness (β=–0.024 mm; P=0.046) and total plaque area (β=–0.318 mm2; P=0.06). LLD protected against progression of carotid atherosclerosis. The protective effect was strongest in long-term users. |
format |
Article in Journal/Newspaper |
author |
Herder, Marit Arntzen, Kjell Arne Johnsen, Stein Harald Eggen, Anne Elise Mathiesen, Ellisiv B. |
author_facet |
Herder, Marit Arntzen, Kjell Arne Johnsen, Stein Harald Eggen, Anne Elise Mathiesen, Ellisiv B. |
author_sort |
Herder, Marit |
title |
Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008 |
title_short |
Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008 |
title_full |
Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008 |
title_fullStr |
Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008 |
title_full_unstemmed |
Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008 |
title_sort |
long-term use of lipid-lowering drugs slows progression of carotid atherosclerosis the tromso study 1994 to 2008 |
publisher |
American Heart Association |
publishDate |
2013 |
url |
https://hdl.handle.net/10037/5734 https://doi.org/10.1161/ATVBAHA.112.300767 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso |
geographic_facet |
Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_relation |
Arteriosclerosis, Thrombosis and Vascular Biology 33(2013) nr. 4 s. 858-U521 FRIDAID 1030673 http://dx.doi.org/10.1161/ATVBAHA.112.300767 1079-5642 https://hdl.handle.net/10037/5734 URN:NBN:no-uit_munin_5442 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1161/ATVBAHA.112.300767 |
container_title |
Arteriosclerosis, Thrombosis, and Vascular Biology |
container_volume |
33 |
container_issue |
4 |
container_start_page |
858 |
op_container_end_page |
862 |
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