Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study.
Background: In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality. Methods: A total of 6640 men and women, aged 25–8...
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ftunivtroemsoe:oai:munin.uit.no:10037/5639 2023-05-15T18:34:27+02:00 Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study. Forsdahl, Signe Helene Solberg, Steinar Singh, Kulbir Jacobsen, Bjarne Koster 2010 https://hdl.handle.net/10037/5639 https://doi.org/10.1093/ije/dyp320 eng eng Oxford University Press International Journal of Epidemiology 39(2010) nr. 1 s. 225-232 FRIDAID 344516 http://dx.doi.org/10.1093/ije/dyp320 0300-5771 https://hdl.handle.net/10037/5639 URN:NBN:no-uit_munin_5333 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Journal article Tidsskriftartikkel Peer reviewed 2010 ftunivtroemsoe https://doi.org/10.1093/ije/dyp320 2021-06-25T17:53:37Z Background: In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality. Methods: A total of 6640 men and women, aged 25–84 years, were included in a 10-year mortality follow-up: 345 subjects with a diagnosed AAA and 6295 subjects with a non-aneurismal aorta. Non-aneurismal aortic diameter and prevalent AAAs were categorized into seven groups. Results: In subjects without an AAA, an aortic diameter 30 mm increased age- and sex-adjusted total mortality [mortality rate ratio (MRR) = 3.73, 95% confidence interval (CI) 1.77–7.89] and CVD mortality (MRR = 9.24, 95% CI 4.07–20.97) compared with subjects with aortic diameter of 21–23 mm. An AAA at screening was strongly associated with deaths from aortic aneurysm and was associated with total (MRR = 1.60, 95% CI 1.31–1.96) and CVD mortality (MRR = 2.41, 95% CI 1.81–3.21). This was not explained by deaths due to an AAA. Adjustments for CVD risk factors could fully explain the increased total, but not CVD mortality in subjects with an AAA. Conclusions: An AAA increases total and CVD mortality. In the large majority of subjects with a non-aneurysmal aorta, the diameter does not influence total or CVD mortality. However, in individuals with a maximal diameter >26 mm (2% of the population), a positive relationship is found Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø International Journal of Epidemiology 39 1 225 232 |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Forsdahl, Signe Helene Solberg, Steinar Singh, Kulbir Jacobsen, Bjarne Koster Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study. |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
description |
Background: In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality. Methods: A total of 6640 men and women, aged 25–84 years, were included in a 10-year mortality follow-up: 345 subjects with a diagnosed AAA and 6295 subjects with a non-aneurismal aorta. Non-aneurismal aortic diameter and prevalent AAAs were categorized into seven groups. Results: In subjects without an AAA, an aortic diameter 30 mm increased age- and sex-adjusted total mortality [mortality rate ratio (MRR) = 3.73, 95% confidence interval (CI) 1.77–7.89] and CVD mortality (MRR = 9.24, 95% CI 4.07–20.97) compared with subjects with aortic diameter of 21–23 mm. An AAA at screening was strongly associated with deaths from aortic aneurysm and was associated with total (MRR = 1.60, 95% CI 1.31–1.96) and CVD mortality (MRR = 2.41, 95% CI 1.81–3.21). This was not explained by deaths due to an AAA. Adjustments for CVD risk factors could fully explain the increased total, but not CVD mortality in subjects with an AAA. Conclusions: An AAA increases total and CVD mortality. In the large majority of subjects with a non-aneurysmal aorta, the diameter does not influence total or CVD mortality. However, in individuals with a maximal diameter >26 mm (2% of the population), a positive relationship is found |
format |
Article in Journal/Newspaper |
author |
Forsdahl, Signe Helene Solberg, Steinar Singh, Kulbir Jacobsen, Bjarne Koster |
author_facet |
Forsdahl, Signe Helene Solberg, Steinar Singh, Kulbir Jacobsen, Bjarne Koster |
author_sort |
Forsdahl, Signe Helene |
title |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study. |
title_short |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study. |
title_full |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study. |
title_fullStr |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study. |
title_full_unstemmed |
Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study. |
title_sort |
abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the tromsø study. |
publisher |
Oxford University Press |
publishDate |
2010 |
url |
https://hdl.handle.net/10037/5639 https://doi.org/10.1093/ije/dyp320 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
International Journal of Epidemiology 39(2010) nr. 1 s. 225-232 FRIDAID 344516 http://dx.doi.org/10.1093/ije/dyp320 0300-5771 https://hdl.handle.net/10037/5639 URN:NBN:no-uit_munin_5333 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1093/ije/dyp320 |
container_title |
International Journal of Epidemiology |
container_volume |
39 |
container_issue |
1 |
container_start_page |
225 |
op_container_end_page |
232 |
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1766219194369572864 |