Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study
Background Previous studies have shown an association between impaired kidney function, assessed by cystatin C-based estimated glomerular filtration rate, and venous thromboembolism. The aim of this study was to investigate whether serum cystatin C was associated with a risk of venous thromboembolis...
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Ferrata Storti Foundation
2012
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Online Access: | https://hdl.handle.net/10037/5040 https://doi.org/10.3324/haematol.2011.057653 |
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ftunivtroemsoe:oai:munin.uit.no:10037/5040 2023-05-15T18:33:55+02:00 Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study Brodin, Ellen Elisabeth Brækkan, Sigrid Kufaas Vik, Anders Brox, Jan Hansen, John-Bjarne 2012 https://hdl.handle.net/10037/5040 https://doi.org/10.3324/haematol.2011.057653 eng eng Ferrata Storti Foundation Haematologica 97(2012) nr. 7 s. 1008-1013 FRIDAID 964472 http://dx.doi.org/10.3324/haematol.2011.057653 0390-6078 https://hdl.handle.net/10037/5040 URN:NBN:no-uit_munin_4750 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Journal article Tidsskriftartikkel Peer reviewed 2012 ftunivtroemsoe https://doi.org/10.3324/haematol.2011.057653 2021-06-25T17:53:32Z Background Previous studies have shown an association between impaired kidney function, assessed by cystatin C-based estimated glomerular filtration rate, and venous thromboembolism. The aim of this study was to investigate whether serum cystatin C was associated with a risk of venous thromboembolism among subjects with normal kidney function in a prospective population-based study. Design and Methods Cystatin C was measured in serum from 3251 men and women with normal kidney function, aged 25–84 years, who participated in the Tromsø study in 1994–1995. Normal kidney function was defined as a creatinine-based estimated glomerular filtration rate greater than 90 mL/min/1.73 m2 and absence of microalbuminuria. Incident venous thromboembolism was registered from the date of inclusion through to the end of follow-up, September 1, 2007. Cox-regression models were used to calculate hazard ratios with 95% confidence intervals for venous thromboembolism. Results There were 83 incident venous thromboembolic events, of which 53 (63.9 %) were provoked, during a median of 12.3 years of follow-up. A one standard deviation (0.11 mg/L) increase in serum cystatin C levels was associated with a 43% (hazard ratio 1.43; 95% confidence interval 1.17–1.72) increased risk of total venous thromboembolism. Subjects with cystatin C levels in the top quartile (≥0.87 mg/L) had a 2.5-fold (hazard ratio 2.51; 95% confidence interval 1.27–4.96) increased risk of venous thromboembolism compared to those with levels in the bottom quartile (≤0.72 mg/L) in adjusted analysis. The risk estimates were even higher for provoked venous thromboembolism (hazard ratio 3.11; 95% confidence interval 1.23–7.86). Conclusions Serum cystatin C levels were associated with the risk of venous thromboembolism in subjects with normal kidney function. Our findings suggest that elevated serum cystatin C levels may promote venous thrombosis beyond reflecting impaired kidney function. Article in Journal/Newspaper Tromso Tromso Tromsø University of Tromsø: Munin Open Research Archive Tromsø Tromso ENVELOPE(16.546,16.546,68.801,68.801) Haematologica 97 7 1008 1013 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Brodin, Ellen Elisabeth Brækkan, Sigrid Kufaas Vik, Anders Brox, Jan Hansen, John-Bjarne Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
description |
Background Previous studies have shown an association between impaired kidney function, assessed by cystatin C-based estimated glomerular filtration rate, and venous thromboembolism. The aim of this study was to investigate whether serum cystatin C was associated with a risk of venous thromboembolism among subjects with normal kidney function in a prospective population-based study. Design and Methods Cystatin C was measured in serum from 3251 men and women with normal kidney function, aged 25–84 years, who participated in the Tromsø study in 1994–1995. Normal kidney function was defined as a creatinine-based estimated glomerular filtration rate greater than 90 mL/min/1.73 m2 and absence of microalbuminuria. Incident venous thromboembolism was registered from the date of inclusion through to the end of follow-up, September 1, 2007. Cox-regression models were used to calculate hazard ratios with 95% confidence intervals for venous thromboembolism. Results There were 83 incident venous thromboembolic events, of which 53 (63.9 %) were provoked, during a median of 12.3 years of follow-up. A one standard deviation (0.11 mg/L) increase in serum cystatin C levels was associated with a 43% (hazard ratio 1.43; 95% confidence interval 1.17–1.72) increased risk of total venous thromboembolism. Subjects with cystatin C levels in the top quartile (≥0.87 mg/L) had a 2.5-fold (hazard ratio 2.51; 95% confidence interval 1.27–4.96) increased risk of venous thromboembolism compared to those with levels in the bottom quartile (≤0.72 mg/L) in adjusted analysis. The risk estimates were even higher for provoked venous thromboembolism (hazard ratio 3.11; 95% confidence interval 1.23–7.86). Conclusions Serum cystatin C levels were associated with the risk of venous thromboembolism in subjects with normal kidney function. Our findings suggest that elevated serum cystatin C levels may promote venous thrombosis beyond reflecting impaired kidney function. |
format |
Article in Journal/Newspaper |
author |
Brodin, Ellen Elisabeth Brækkan, Sigrid Kufaas Vik, Anders Brox, Jan Hansen, John-Bjarne |
author_facet |
Brodin, Ellen Elisabeth Brækkan, Sigrid Kufaas Vik, Anders Brox, Jan Hansen, John-Bjarne |
author_sort |
Brodin, Ellen Elisabeth |
title |
Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study |
title_short |
Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study |
title_full |
Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study |
title_fullStr |
Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study |
title_full_unstemmed |
Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study |
title_sort |
cystatin c is associated with risk of venous thromboembolism in subjects with normal kidney function - the tromso study |
publisher |
Ferrata Storti Foundation |
publishDate |
2012 |
url |
https://hdl.handle.net/10037/5040 https://doi.org/10.3324/haematol.2011.057653 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromsø Tromso |
geographic_facet |
Tromsø Tromso |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
Haematologica 97(2012) nr. 7 s. 1008-1013 FRIDAID 964472 http://dx.doi.org/10.3324/haematol.2011.057653 0390-6078 https://hdl.handle.net/10037/5040 URN:NBN:no-uit_munin_4750 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.3324/haematol.2011.057653 |
container_title |
Haematologica |
container_volume |
97 |
container_issue |
7 |
container_start_page |
1008 |
op_container_end_page |
1013 |
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1766218551069245440 |