Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromso Staph and Skin Study
Vitamin D induces the expression of antimicrobial peptides with activity against Staphylococcus aureus. Thus, we studied the association between serum 25-hydroxyvitamin D (25(OH)D) and S. aureus nasal colonization and carriage. Nasal swabs, blood samples and clinical data from 2,115 women and 1,674...
Published in: | European Journal of Clinical Microbiology & Infectious Diseases |
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Springer Verlag
2012
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Online Access: | https://hdl.handle.net/10037/4969 https://doi.org/10.1007/s10096-011-1331-x |
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ftunivtroemsoe:oai:munin.uit.no:10037/4969 2023-05-15T18:33:54+02:00 Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromso Staph and Skin Study Olsen, Karina Falch, Birgit Margrethe Danielsen, Kjersti Johannessen, Mona Sollid, Johanna U Ericson Thune, Inger Grimnes, Guri Jorde, Rolf Simonsen, Gunnar Skov Furberg, Anne-Sofie 2012 https://hdl.handle.net/10037/4969 https://doi.org/10.1007/s10096-011-1331-x eng eng Springer Verlag European Journal of Clinical Microbiology and Infectious Diseases 31(2012) nr. 4 s. 465-473 FRIDAID 929461 http://dx.doi.org/10.1007/s10096-011-1331-x 0934-9723 https://hdl.handle.net/10037/4969 URN:NBN:no-uit_munin_4734 openAccess VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical molecular biology: 711 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711 dental and veterinary science disciplines: 710::Medical microbiology: 715 odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715 dental and veterinary science disciplines: 710::Medical immunology: 716 odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716 Journal article Tidsskriftartikkel Peer reviewed 2012 ftunivtroemsoe https://doi.org/10.1007/s10096-011-1331-x 2021-06-25T17:53:32Z Vitamin D induces the expression of antimicrobial peptides with activity against Staphylococcus aureus. Thus, we studied the association between serum 25-hydroxyvitamin D (25(OH)D) and S. aureus nasal colonization and carriage. Nasal swabs, blood samples and clinical data from 2,115 women and 1,674 men, aged 30–87 years, were collected in the Tromsø Staph and Skin Study 2007–08, as part of the population-based sixth Tromsø Study. Multivariate logistic regression analyses were stratified by recognized risk factors for S. aureus carriage: sex, age and smoking. In non-smoking men, we observed a 6.6% and 6.7% decrease in the probability of S. aureus colonization and carriage, respectively, by each 5 nmol/l increase in serum 25(OH)D concentration (P < 0.001 and P = 0.001), and serum 25(OH)D > 59 nmol/l and ≥75 nmol/l as thresholds for ~30% and ~50% reduction in S. aureus colonization and carriage. In non-smoking men aged 44–60 years, the odds ratio for S. aureus colonization was 0.44 (95% confidence interval, 0.28−0.69) in the top tertile of serum 25(OH)D versus the bottom tertile. In women and smokers there were no such associations. Our study supports that serum vitamin D is a determinant of S. aureus colonization and carriage. Article in Journal/Newspaper Tromso Tromso Tromsø University of Tromsø: Munin Open Research Archive Tromso ENVELOPE(16.546,16.546,68.801,68.801) Tromsø European Journal of Clinical Microbiology & Infectious Diseases 31 4 465 473 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical molecular biology: 711 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711 dental and veterinary science disciplines: 710::Medical microbiology: 715 odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715 dental and veterinary science disciplines: 710::Medical immunology: 716 odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716 |
spellingShingle |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical molecular biology: 711 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711 dental and veterinary science disciplines: 710::Medical microbiology: 715 odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715 dental and veterinary science disciplines: 710::Medical immunology: 716 odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716 Olsen, Karina Falch, Birgit Margrethe Danielsen, Kjersti Johannessen, Mona Sollid, Johanna U Ericson Thune, Inger Grimnes, Guri Jorde, Rolf Simonsen, Gunnar Skov Furberg, Anne-Sofie Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromso Staph and Skin Study |
topic_facet |
VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical molecular biology: 711 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711 dental and veterinary science disciplines: 710::Medical microbiology: 715 odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715 dental and veterinary science disciplines: 710::Medical immunology: 716 odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716 |
description |
Vitamin D induces the expression of antimicrobial peptides with activity against Staphylococcus aureus. Thus, we studied the association between serum 25-hydroxyvitamin D (25(OH)D) and S. aureus nasal colonization and carriage. Nasal swabs, blood samples and clinical data from 2,115 women and 1,674 men, aged 30–87 years, were collected in the Tromsø Staph and Skin Study 2007–08, as part of the population-based sixth Tromsø Study. Multivariate logistic regression analyses were stratified by recognized risk factors for S. aureus carriage: sex, age and smoking. In non-smoking men, we observed a 6.6% and 6.7% decrease in the probability of S. aureus colonization and carriage, respectively, by each 5 nmol/l increase in serum 25(OH)D concentration (P < 0.001 and P = 0.001), and serum 25(OH)D > 59 nmol/l and ≥75 nmol/l as thresholds for ~30% and ~50% reduction in S. aureus colonization and carriage. In non-smoking men aged 44–60 years, the odds ratio for S. aureus colonization was 0.44 (95% confidence interval, 0.28−0.69) in the top tertile of serum 25(OH)D versus the bottom tertile. In women and smokers there were no such associations. Our study supports that serum vitamin D is a determinant of S. aureus colonization and carriage. |
format |
Article in Journal/Newspaper |
author |
Olsen, Karina Falch, Birgit Margrethe Danielsen, Kjersti Johannessen, Mona Sollid, Johanna U Ericson Thune, Inger Grimnes, Guri Jorde, Rolf Simonsen, Gunnar Skov Furberg, Anne-Sofie |
author_facet |
Olsen, Karina Falch, Birgit Margrethe Danielsen, Kjersti Johannessen, Mona Sollid, Johanna U Ericson Thune, Inger Grimnes, Guri Jorde, Rolf Simonsen, Gunnar Skov Furberg, Anne-Sofie |
author_sort |
Olsen, Karina |
title |
Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromso Staph and Skin Study |
title_short |
Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromso Staph and Skin Study |
title_full |
Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromso Staph and Skin Study |
title_fullStr |
Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromso Staph and Skin Study |
title_full_unstemmed |
Staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin D levels, gender and smoking status. The Tromso Staph and Skin Study |
title_sort |
staphylococcus aureus nasal carriage is associated with serum 25-hydroxyvitamin d levels, gender and smoking status. the tromso staph and skin study |
publisher |
Springer Verlag |
publishDate |
2012 |
url |
https://hdl.handle.net/10037/4969 https://doi.org/10.1007/s10096-011-1331-x |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso Tromsø |
geographic_facet |
Tromso Tromsø |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
European Journal of Clinical Microbiology and Infectious Diseases 31(2012) nr. 4 s. 465-473 FRIDAID 929461 http://dx.doi.org/10.1007/s10096-011-1331-x 0934-9723 https://hdl.handle.net/10037/4969 URN:NBN:no-uit_munin_4734 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1007/s10096-011-1331-x |
container_title |
European Journal of Clinical Microbiology & Infectious Diseases |
container_volume |
31 |
container_issue |
4 |
container_start_page |
465 |
op_container_end_page |
473 |
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1766218531754475520 |