Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study
Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have...
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Online Access: | https://hdl.handle.net/10037/4936 https://doi.org/10.1371/journal.pone.0037295 |
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ftunivtroemsoe:oai:munin.uit.no:10037/4936 2023-05-15T18:34:35+02:00 Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study Jorde, Rolf Schirmer, Henrik Wilsgaard, Tom Joakimsen, Ragnar Martin Mathiesen, Ellisiv B. Njølstad, Inger Løchen, Maja-Lisa Figenschau, Yngve Berg, Jens Petter Svartberg, Johan Grimnes, Guri 2012 https://hdl.handle.net/10037/4936 https://doi.org/10.1371/journal.pone.0037295 eng eng Public Library of Science (PLoS) PLoS ONE (2012), vol. 7(5): e37295 FRIDAID 946704 http://dx.doi.org/10.1371/journal.pone.0037295 1932-6203 https://hdl.handle.net/10037/4936 URN:NBN:no-uit_munin_4657 openAccess VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Journal article Tidsskriftartikkel Peer reviewed 2012 ftunivtroemsoe https://doi.org/10.1371/journal.pone.0037295 2021-06-25T17:53:32Z Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these SNPs and health. DNA was prepared from subjects who participated in the fourth survey of the Tromsø Study in 1994–1995 and who were registered with the endpoints MI, T2DM, cancer or death as well as a randomly selected control group. The endpoint registers were complete up to 2007–2010. Genotyping was performed for 17 SNPs related to the serum 25(OH)D level. A total of 9528 subjects were selected for genetic analyses which were successfully performed for at least one SNP in 9471 subjects. Among these, 2025 were registered with MI, 1092 with T2DM, 2924 with cancer and 3828 had died. The mean differences in serum 25(OH)D levels between SNP genotypes with the lowest and highest serum 25(OH)D levels varied from 0.1 to 7.8 nmol/L. A genotype score based on weighted risk alleles regarding low serum 25(OH)D levels was established. There was no consistent association between the genotype score or individuals SNPs and MI, T2DM, cancer, mortality or risk factors for disease. However, for rs6013897 genotypes (located at the 24-hydroxylase gene (CYP24A1)) there was a significant association with breast cancer (P<0.05). Our results do not support nor exclude a causal relationship between serum 25(OH)D levels and MI, T2DM, cancer or mortality, and our observation on breast cancer needs confirmation. Further genetic studies are warranted, particularly in populations with vitamin D deficiency. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø PLoS ONE 7 5 e37295 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Jorde, Rolf Schirmer, Henrik Wilsgaard, Tom Joakimsen, Ragnar Martin Mathiesen, Ellisiv B. Njølstad, Inger Løchen, Maja-Lisa Figenschau, Yngve Berg, Jens Petter Svartberg, Johan Grimnes, Guri Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 |
description |
Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these SNPs and health. DNA was prepared from subjects who participated in the fourth survey of the Tromsø Study in 1994–1995 and who were registered with the endpoints MI, T2DM, cancer or death as well as a randomly selected control group. The endpoint registers were complete up to 2007–2010. Genotyping was performed for 17 SNPs related to the serum 25(OH)D level. A total of 9528 subjects were selected for genetic analyses which were successfully performed for at least one SNP in 9471 subjects. Among these, 2025 were registered with MI, 1092 with T2DM, 2924 with cancer and 3828 had died. The mean differences in serum 25(OH)D levels between SNP genotypes with the lowest and highest serum 25(OH)D levels varied from 0.1 to 7.8 nmol/L. A genotype score based on weighted risk alleles regarding low serum 25(OH)D levels was established. There was no consistent association between the genotype score or individuals SNPs and MI, T2DM, cancer, mortality or risk factors for disease. However, for rs6013897 genotypes (located at the 24-hydroxylase gene (CYP24A1)) there was a significant association with breast cancer (P<0.05). Our results do not support nor exclude a causal relationship between serum 25(OH)D levels and MI, T2DM, cancer or mortality, and our observation on breast cancer needs confirmation. Further genetic studies are warranted, particularly in populations with vitamin D deficiency. |
format |
Article in Journal/Newspaper |
author |
Jorde, Rolf Schirmer, Henrik Wilsgaard, Tom Joakimsen, Ragnar Martin Mathiesen, Ellisiv B. Njølstad, Inger Løchen, Maja-Lisa Figenschau, Yngve Berg, Jens Petter Svartberg, Johan Grimnes, Guri |
author_facet |
Jorde, Rolf Schirmer, Henrik Wilsgaard, Tom Joakimsen, Ragnar Martin Mathiesen, Ellisiv B. Njølstad, Inger Løchen, Maja-Lisa Figenschau, Yngve Berg, Jens Petter Svartberg, Johan Grimnes, Guri |
author_sort |
Jorde, Rolf |
title |
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study |
title_short |
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study |
title_full |
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study |
title_fullStr |
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study |
title_full_unstemmed |
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study |
title_sort |
polymorphisms related to the serum 25-hydroxyvitamin d level and risk of myocardial infarction, diabetes, cancer and mortality. the tromsø study |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://hdl.handle.net/10037/4936 https://doi.org/10.1371/journal.pone.0037295 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
PLoS ONE (2012), vol. 7(5): e37295 FRIDAID 946704 http://dx.doi.org/10.1371/journal.pone.0037295 1932-6203 https://hdl.handle.net/10037/4936 URN:NBN:no-uit_munin_4657 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0037295 |
container_title |
PLoS ONE |
container_volume |
7 |
container_issue |
5 |
container_start_page |
e37295 |
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1766219379846938624 |