High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study
This article is part of Eirin Hald's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/7006 High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but conflicting results have been reported on its role in venous thromboembolic di...
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Ferrata Storti Foundation
2011
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Online Access: | https://hdl.handle.net/10037/3855 https://doi.org/10.3324/haematol.2010.034991 |
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ftunivtroemsoe:oai:munin.uit.no:10037/3855 2023-05-15T18:33:55+02:00 High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study Hald, Erin Mathiesen Brækkan, Sigrid Kufaas Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Brox, Jan Hansen, John-Bjarne 2011 https://hdl.handle.net/10037/3855 https://doi.org/10.3324/haematol.2010.034991 eng eng Ferrata Storti Foundation Haematologica 96(2011) nr. 8 s. 1189-1194 FRIDAID 848412 doi:10.3324/haematol.2010.034991 0390-6078 https://hdl.handle.net/10037/3855 URN:NBN:no-uit_munin_3577 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Journal article Tidsskriftartikkel Peer reviewed 2011 ftunivtroemsoe https://doi.org/10.3324/haematol.2010.034991 2021-06-25T17:53:11Z This article is part of Eirin Hald's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/7006 High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population. High-sensitivity C-reactive protein was measured in serum samples from 6,426 men and women, aged 25-84 years, recruited from the Tromsø Study in the period 1994-1995. Incident venous thromboembolism events (n=209) were registered during a median of 12.5 years of follow up. Cox’s proportional hazards regression models were used to estimate age- and genderand multivariable-adjusted hazard ratios with 95% confidence intervals for total venous thromboembolism, and for provoked and unprovoked venous thromboembolism by increasing levels of high-sensitivity C-reactive protein. There was no increased risk of venous thromboembolism per 1 standard deviation increase in high-sensitivity C-reactive protein (hazard ratio 1.08; 95% confidence interval 0.95-1.23) or across quartiles of high-sensitivity C-reactive protein (P for trend 0.6) in analyses adjusted for age and gender. Further adjustment for body mass index, smoking and diabetes did not alter the risk estimates. Moreover, high-sensitivity C-reactive protein was not associated with venous thromboembolism in either gender specific analysis or in separate analyses of provoked and unprovoked venous thromboembolism events. In this prospective study, serum levels of high-sensitivity C-reactive protein were not associated with future development of venous thromboembolism. Our findings do not suggest a causal role for C-reactive protein in the pathogenesis of venous thromboembolism. Article in Journal/Newspaper Tromso Tromso Tromsø University of Tromsø: Munin Open Research Archive Tromso ENVELOPE(16.546,16.546,68.801,68.801) Tromsø Haematologica 96 8 1189 1194 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Hald, Erin Mathiesen Brækkan, Sigrid Kufaas Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Brox, Jan Hansen, John-Bjarne High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
description |
This article is part of Eirin Hald's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/7006 High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population. High-sensitivity C-reactive protein was measured in serum samples from 6,426 men and women, aged 25-84 years, recruited from the Tromsø Study in the period 1994-1995. Incident venous thromboembolism events (n=209) were registered during a median of 12.5 years of follow up. Cox’s proportional hazards regression models were used to estimate age- and genderand multivariable-adjusted hazard ratios with 95% confidence intervals for total venous thromboembolism, and for provoked and unprovoked venous thromboembolism by increasing levels of high-sensitivity C-reactive protein. There was no increased risk of venous thromboembolism per 1 standard deviation increase in high-sensitivity C-reactive protein (hazard ratio 1.08; 95% confidence interval 0.95-1.23) or across quartiles of high-sensitivity C-reactive protein (P for trend 0.6) in analyses adjusted for age and gender. Further adjustment for body mass index, smoking and diabetes did not alter the risk estimates. Moreover, high-sensitivity C-reactive protein was not associated with venous thromboembolism in either gender specific analysis or in separate analyses of provoked and unprovoked venous thromboembolism events. In this prospective study, serum levels of high-sensitivity C-reactive protein were not associated with future development of venous thromboembolism. Our findings do not suggest a causal role for C-reactive protein in the pathogenesis of venous thromboembolism. |
format |
Article in Journal/Newspaper |
author |
Hald, Erin Mathiesen Brækkan, Sigrid Kufaas Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Brox, Jan Hansen, John-Bjarne |
author_facet |
Hald, Erin Mathiesen Brækkan, Sigrid Kufaas Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Brox, Jan Hansen, John-Bjarne |
author_sort |
Hald, Erin Mathiesen |
title |
High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study |
title_short |
High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study |
title_full |
High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study |
title_fullStr |
High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study |
title_full_unstemmed |
High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study |
title_sort |
high-sensitivity c-reactive protein is not a risk factor for venous thromboembolism: the tromso study |
publisher |
Ferrata Storti Foundation |
publishDate |
2011 |
url |
https://hdl.handle.net/10037/3855 https://doi.org/10.3324/haematol.2010.034991 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso Tromsø |
geographic_facet |
Tromso Tromsø |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
Haematologica 96(2011) nr. 8 s. 1189-1194 FRIDAID 848412 doi:10.3324/haematol.2010.034991 0390-6078 https://hdl.handle.net/10037/3855 URN:NBN:no-uit_munin_3577 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.3324/haematol.2010.034991 |
container_title |
Haematologica |
container_volume |
96 |
container_issue |
8 |
container_start_page |
1189 |
op_container_end_page |
1194 |
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1766218544488382464 |