Clinical and laboratory aspects of vitamin D in relation to type 2 diabetes and osteoporosis. Results from the Tromsø Study and two randomized controlled trials.
The papers of this thesis are not available in Munin: 1. Grimnes G, Almaas B, Eggen AE, Emaus N, Figenschau Y, Hopstock L, Hutchinson MS, Methlie P, Mihailova A, Sneve M, Torjesen P, Wilsgaard T and Jorde R.: 'Effect of smoking on the serum levels of 25-hydroxyvitamin D depends on the assay emp...
Main Author: | |
---|---|
Format: | Doctoral or Postdoctoral Thesis |
Language: | English |
Published: |
University of Tromsø
2011
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/3825 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/3825 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/3825 2023-05-15T18:34:26+02:00 Clinical and laboratory aspects of vitamin D in relation to type 2 diabetes and osteoporosis. Results from the Tromsø Study and two randomized controlled trials. Grimnes, Guri 2011-11-18 https://hdl.handle.net/10037/3825 eng eng University of Tromsø Universitetet i Tromsø https://hdl.handle.net/10037/3825 URN:NBN:no-uit_munin_3535 openAccess Copyright 2011 The Author(s) VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 The Tromsø Study Tromsøundersøkelsen DOKTOR-003 Doctoral thesis Doktorgradsavhandling 2011 ftunivtroemsoe 2021-06-25T17:53:09Z The papers of this thesis are not available in Munin: 1. Grimnes G, Almaas B, Eggen AE, Emaus N, Figenschau Y, Hopstock L, Hutchinson MS, Methlie P, Mihailova A, Sneve M, Torjesen P, Wilsgaard T and Jorde R.: 'Effect of smoking on the serum levels of 25-hydroxyvitamin D depends on the assay employed', European Journal of Endocrinology (2010) 163:339-48. Available at http://dx.doi.org/10.1530/EJE-10-0150 2. Grimnes G, Emaus N, Joakimsen RM, Figenschau Y, Jenssen T, Njølstad I, Schirmer H, Jorde R.: 'Baseline serum 25-hydroxyvitamin D concentrations in the Tromsø Study 1994-95 and risk of developing type 2 diabetes mellitus during eleven years of followup', Diabetic Medicine (2010);27:1107-15. Available at http://dx.doi.org/10.1111/j.1464-5491.2010.03092.x 3. Grimnes G, Figenschau Y, Almås, B, Jorde R.: 'Vitamin D, insulin secretion, sensitivity and lipids – the results from a case-control study and a randomized controlled trial using hyperglycemic clamp technique', Diabetes (2011) vol. 25, pp 1-10. Available at http://dx.doi.org/10.2337/db11-0650 4. Grimnes G, Joakimsen RM, Figenschau Y, Torjesen P, Almås B, Jorde R.: 'The effect of high dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass – a randomized controlled one-year trial', Osteoporosis International (2012) vol. 23(1) pp. 201-211. Available at http://dx.doi.org/10.1007/s00198-011-1845-1 There has been a large interest in possible beneficial health effects of increasing the vitamin D (as measured by 25-hydroxyvitamin D (25(OH)D)) levels in the population. Data from the Tromsø Study were used to assess the relation between serum 25(OH)D levels and the risk of subsequent type 2 diabetes in 6119 participants. This risk was approximately doubled in the lowest serum 25(OH)D quartile as compared to the highest quartile. This could to a large extent be explained by higher body mass index in the lowest quartile. When thereafter comparing 52 persons with high and 108 persons with low serum 25(OH)D levels, we found more beneficial levels of glucose and lipid measures in those with high serum 25(OH)D levels. However, there was no improvement in the same measures in the low serum 25(OH)D group after six months supplementation with high dose vitamin D (approximately 150 mikrogram or 6000 international units/day) as compared to placebo. In another study, we compared one year treatment with standard dose of vitamin D (800 international units) with the same high dose vitamin D among 297 women with reduced bone mineral density. Both doses improved or maintained bone mineral density with no differences between the groups. These results do not support the use of vitamin D in such high doses. Further studies are needed to assess the ideal level of serum 25(OH)D. We have further demonstrated that smoking might interfere with 25(OH)D laboratory analyses. This is important to consider in developing and validating such methods. Doctoral or Postdoctoral Thesis Tromsø University of Tromsø: Munin Open Research Archive Tromsø |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 The Tromsø Study Tromsøundersøkelsen DOKTOR-003 |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 The Tromsø Study Tromsøundersøkelsen DOKTOR-003 Grimnes, Guri Clinical and laboratory aspects of vitamin D in relation to type 2 diabetes and osteoporosis. Results from the Tromsø Study and two randomized controlled trials. |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 The Tromsø Study Tromsøundersøkelsen DOKTOR-003 |
description |
The papers of this thesis are not available in Munin: 1. Grimnes G, Almaas B, Eggen AE, Emaus N, Figenschau Y, Hopstock L, Hutchinson MS, Methlie P, Mihailova A, Sneve M, Torjesen P, Wilsgaard T and Jorde R.: 'Effect of smoking on the serum levels of 25-hydroxyvitamin D depends on the assay employed', European Journal of Endocrinology (2010) 163:339-48. Available at http://dx.doi.org/10.1530/EJE-10-0150 2. Grimnes G, Emaus N, Joakimsen RM, Figenschau Y, Jenssen T, Njølstad I, Schirmer H, Jorde R.: 'Baseline serum 25-hydroxyvitamin D concentrations in the Tromsø Study 1994-95 and risk of developing type 2 diabetes mellitus during eleven years of followup', Diabetic Medicine (2010);27:1107-15. Available at http://dx.doi.org/10.1111/j.1464-5491.2010.03092.x 3. Grimnes G, Figenschau Y, Almås, B, Jorde R.: 'Vitamin D, insulin secretion, sensitivity and lipids – the results from a case-control study and a randomized controlled trial using hyperglycemic clamp technique', Diabetes (2011) vol. 25, pp 1-10. Available at http://dx.doi.org/10.2337/db11-0650 4. Grimnes G, Joakimsen RM, Figenschau Y, Torjesen P, Almås B, Jorde R.: 'The effect of high dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass – a randomized controlled one-year trial', Osteoporosis International (2012) vol. 23(1) pp. 201-211. Available at http://dx.doi.org/10.1007/s00198-011-1845-1 There has been a large interest in possible beneficial health effects of increasing the vitamin D (as measured by 25-hydroxyvitamin D (25(OH)D)) levels in the population. Data from the Tromsø Study were used to assess the relation between serum 25(OH)D levels and the risk of subsequent type 2 diabetes in 6119 participants. This risk was approximately doubled in the lowest serum 25(OH)D quartile as compared to the highest quartile. This could to a large extent be explained by higher body mass index in the lowest quartile. When thereafter comparing 52 persons with high and 108 persons with low serum 25(OH)D levels, we found more beneficial levels of glucose and lipid measures in those with high serum 25(OH)D levels. However, there was no improvement in the same measures in the low serum 25(OH)D group after six months supplementation with high dose vitamin D (approximately 150 mikrogram or 6000 international units/day) as compared to placebo. In another study, we compared one year treatment with standard dose of vitamin D (800 international units) with the same high dose vitamin D among 297 women with reduced bone mineral density. Both doses improved or maintained bone mineral density with no differences between the groups. These results do not support the use of vitamin D in such high doses. Further studies are needed to assess the ideal level of serum 25(OH)D. We have further demonstrated that smoking might interfere with 25(OH)D laboratory analyses. This is important to consider in developing and validating such methods. |
format |
Doctoral or Postdoctoral Thesis |
author |
Grimnes, Guri |
author_facet |
Grimnes, Guri |
author_sort |
Grimnes, Guri |
title |
Clinical and laboratory aspects of vitamin D in relation to type 2 diabetes and osteoporosis. Results from the Tromsø Study and two randomized controlled trials. |
title_short |
Clinical and laboratory aspects of vitamin D in relation to type 2 diabetes and osteoporosis. Results from the Tromsø Study and two randomized controlled trials. |
title_full |
Clinical and laboratory aspects of vitamin D in relation to type 2 diabetes and osteoporosis. Results from the Tromsø Study and two randomized controlled trials. |
title_fullStr |
Clinical and laboratory aspects of vitamin D in relation to type 2 diabetes and osteoporosis. Results from the Tromsø Study and two randomized controlled trials. |
title_full_unstemmed |
Clinical and laboratory aspects of vitamin D in relation to type 2 diabetes and osteoporosis. Results from the Tromsø Study and two randomized controlled trials. |
title_sort |
clinical and laboratory aspects of vitamin d in relation to type 2 diabetes and osteoporosis. results from the tromsø study and two randomized controlled trials. |
publisher |
University of Tromsø |
publishDate |
2011 |
url |
https://hdl.handle.net/10037/3825 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://hdl.handle.net/10037/3825 URN:NBN:no-uit_munin_3535 |
op_rights |
openAccess Copyright 2011 The Author(s) |
_version_ |
1766219171679436800 |